DOI:

10.37988/1811-153X_2024_4_82

Correlation of oral microbiota composition and sIgA in healthy individuals and patients with peri-implantitis

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Authors

  • L.A. Burlakova 1, postgraduate at the Maxillofacial surgery and surgical dentistry Department
    ORCID: 0000-0002-5321-3304
  • O.A. Gizinger 1, Doctor of Science in Biology, professor of the Microbiology Department
    ORCID: 0000-0001-9302-0155
  • A.A. Muraev 1, Doctor of Science in Medicine, professor of the Maxillofacial surgery and surgical dentistry Department
    ORCID: 0000-0003-3982-5512
  • E.V. Delidova 2, PhD in Medical Sciences, dental surgeon, periodontist, implantologist
    ORCID: 0009-0007-3257-1296
  • S.Yu. Ivanov 1, 3, Russian Academy of Science corresponding member, Doctor of Science in Medicine, full professor of the Maxillofacial surgery and surgical dentistry Department; full professor of the Maxillofacial surgery Department
    ORCID: 0000-0001-5458-0192
  • A.B. Dymnikov 1, PhD in Medical Sciences, assistant professor of the Oral and maxillofacial surgery Department
    ORCID: 0000-0001-8980-6235
  • 1 RUDN University, 117198, Moscow, Russia
  • 2 DentaVita Prestige LLC, 121069, Moscow, Russia
  • 3 Sechenov University, 119991, Moscow, Russia

Abstract

A study of oral microbiota through 16S rRNA metagenomic sequencing and secretory immunoglobulin A (sIgA) was conducted. The aim of the study was to evaluate the correlation between the results obtained by 16S rRNA sequencing method and the level of sIgA.
Materials and methods.
The study involved saliva from 18 patients with peri-implantitis aged between 18 and 80 years and 18 individuals with oral implants without pathological changes.
Results.
The level of secretory IgA in healthy individuals (1.1 g/L) and in patients with peri-implantitis (0.52 g/L) significantly differs. In peri-implantitis, the following types of bacteria predominate in the oral microbiome: Haemophilus parainfluenzae (9.3%), Fusobacterium nucleatum (4.8%), Porphyromonas gingivalis (3.3%), Veillonella dispar/parvula (9.4%), Haemophilus haemolyticus/influenzae (1.5%).
Conclusion.
A direct correlation has been identified between the level of sIgA in saliva and the diversity of microorganisms in the oral cavity of the subjects examined.

Key words:

peri-implantitis, microbiome, sIgA, saliva, 16S rRNA metagenomic sequencing

For Citation

[1]
Burlakova L.A., Gizinger O.A., Muraev A.A., Delidova E.V., Ivanov S.Yu., Dymnikov A.B. Correlation of oral microbiota composition and sIgA in healthy individuals and patients with peri-implantitis. Clinical Dentistry (Russia).  2024; 27 (4): 82—88. DOI: 10.37988/1811-153X_2024_4_82

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Received

September 22, 2024

Accepted

October 29, 2024

Published on

December 17, 2024