Peculiarities of functional activity of antioxidant enzymes in oral fluid of patients with aphthous stomatitis during therapy

Abstract

Chronic recurrent aphthous stomatitis (CRAS) Is a chronic inflammatory disease of the mucous membrane of the oral cavity. Patients with CPAS are characterized by an increase in the activity of pro-oxidant processes and decreased function of the antioxidant system. The aim is to study the functional activity of antioxidant enzymes in the oral liquid of patients with CRAS on the background of therapy with antiseptics and reparants.
Materials and methods.
The oral fluid of 60 people with the diagnosis of CRAS was studied with the diagnosis of CRAS, divided into 2 equal groups: in the group I patients used chlorhexidine for rinsing (control), in group II — octenidine+phenoxyethanol for 7 days. After 7 days the treatment was continued with reparants (Kolitex-gel-DNA-L, deproteinized dialysate from the blood of healthy dairy calves, sea buckthorn oil, sea buckthorn oil), calves, sea buckthorn oil), for which each group of patients was divided into three subgroups. To assess the enzyme link of the antioxidant system we determined activity of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase on the 1st, 7th and 21st days of the study in oral fluid.
Results.
In patients of control group I on the 7th day the activity of catalase increased by 20,9%, SOD activity — by 22,2%, GR activity — by 20,4%, GP activity — by 56,4% of the initial value. 56.4% of the initial value, and in group II patients the activity of catalase increased by by 28.2%, SOD activity — by 30.8%, GR activity — by 25.5%, and GP activity — by 82.7% of the initial value.
Conclusions.
In patients with aphthous stomatitis the functioning of the of antiradical defense enzymes in oral fluid is in imbalance. At The use of antiseptics with an anesthetic together with various reparants in patients with CRAS, there is a restoration of the activity of enzymes of antiradical defense enzymes in the oral fluid, which plays an important role in the therapy of chronic inflammatory diseases of chronic inflammatory diseases. The use of antiseptics and reparants helps to equalize oxidative stress and improve the overall condition of the oral cavity of the oral cavity in patients with CRAS.