DOI:

10.37988/1811-153X_2024_2_83

Structural and functional changes of salivary glands in patients after iodine-131 radiotherapy in the complex treatment of thyroid diseases

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Authors

  • E.I. Dubrovina 1, assistant at the Surgical dentistry Department
    ORCID: 0009-0007-1465-889X
  • I.V. Gayduk 1, PhD in Medical Sciences, associate professor of the Surgical dentistry Department
    ORCID: 0000-0001-7380-1296
  • A.M. Panin 1, PhD in Medical Sciences, full professor of theSurgical dentistry Department
    ORCID: 0000-0001-6073-1591
  • A.M. Tsitsiashvili 1, PhD in Medical Sciences, professor of the Surgical dentistry Department
    ORCID: 0000-0002-4737-8508
  • A.Kh. Oganesyan 1, 5th year student at the Dental Faculty
    ORCID: 0009-0000-0480-1225
  • 1 Russian University of Medicine, 127006, Moscow, Russia

Abstract

Radiotherapy is one of the most important elements of the combined treatment of thyroid diseases, it is used depending on the degree of postoperative risk of recurrence of the disease and in the case of distant metastases. The side effect of radioiodine therapy on the salivary glands may occur in the early and late periods. Despite the many works devoted to sialoadenitis after radioiodine therapy, there is currently no clear characteristic of radio-induced sialoadenitis and a standard of diagnosis.
Materials and methods.
The frequency of structural and functional disorders of the salivary glands was studied in 45 patients with thyroid diseases treated with iodine-131. Basic, private and special methods of examination of the salivary glands were used.
Results.
The most frequent clinical manifestation of salivary gland involvement, periodic enlargement, was detected on both sides in 38% of patients, in 53% — on the one hand. Simultaneous damage to the parotid and submandibular salivary glands was found in 9% of patients. Parotid salivary glands (85% of cases) are more sensitive to the development of postradiative sialoadenitis than submandibular glands (15% of cases).
Conclusion.
In most cases, the structural and functional consistency of the salivary glands is determined. Irreversible changes develop mainly in one salivary gland. There is a connection between the lack of secretion from the excretory duct and the lack of contrast between the intragastric ducts.

Key words:

sialoadenitis, sialoscintigraphy, radioiodine therapy, thyroid diseases

For Citation

[1]
Dubrovina E.I., Gayduk I.V., Panin A.M., Tsitsiashvili A.M., Oganesyan A.Kh. Structural and functional changes of salivary glands in patients after iodine-131 radiotherapy in the complex treatment of thyroid diseases. Clinical Dentistry (Russia).  2024; 27 (2): 83—89. DOI: 10.37988/1811-153X_2024_2_83

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Received

December 15, 2023

Accepted

May 20, 2024

Published on

June 28, 2024