DOI:

10.37988/1811-153X_2024_1_40

The application of the medication Superlimf in the peri-implant area after vestibuloplasty

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Authors

  • A.D. Lysov 1, PhD in Medical sciences, associate professor of the Dentistry Department
    ORCID: 0000-0003-3369-8030
  • M.A. Postnikov 2, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-2232-8870
  • S.E. Chigarina 2, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-7008-5981
  • M.D. Alesheva 3, general practice dentist, dental surgeon
    ORCID: 0009-0001-1021-4956
  • V.A. Lysova 2, 4th year student
    ORCID: 0009-0000-1807-5463
  • 1 Medical University “REAVIZ”, 443001, Samara, Russia
  • 2 Samara State Medical University, 443099, Samara, Russia
  • 3 Dental clinic “Dental-Antistress”, 443090, Samara, Russia

Abstract

During dental implantation, it is necessary to achieve not only osseointegration of an implant, but also mucogingival integration in the suprastructure area. The solution of the optimization problem of regeneration processes in the peri-implant area after vestibuloplasty is aimed at finding immunomodulating agents for local application.
Materials and methods.
The study involved 32 patients aged 27 to 73 years with previously installed dental implants and with insufficient volume of the attached gum in the peri-implant area. Patients underwent vestibuloplasty using a donor free epithelial autograft obtained from one of the two segments of the hard palate. After vestibuloplasty, the patients of the main group (n=16) were treated with the medicaton Superlimf in the form of alginate plates, while the adhesive gum balm Asepta was used for the patients in the control group (n=16).
Results.
During the assessment of clinical parameters for photoprotocols, 4 photometric parameters were identified according to the degree of coating of the wound surface with fibrinous film. It was found that the minimum area from 0 to 25% was observed in 75% of patients in the main group and only in 19% of patients in the control group (p=0005). In the control group, the coverage area of the wound surface in the range of 25—50% was 69% of cases versus 19% in the main group (p=0.013). Large areas of fibrinous film coverage from 50% to 75% and within 75—100% in both groups were found in single quantities: the coverage area of 50—75% in one patient in the main group and one patient in the control group; the coverage area of 75—100% in one patient in the control group, and in No patients of the main group were observed (χ2=10.79, p=0.012). Cytological examination demonstrated the ratio of the activity of regenerative and inflammatory processes in the operated area of patients of the main and control groups. The predominance of regenerative processes was 69% in the main group versus 19% of cases in the control group (p=0.013). The equal severity of regenerative and inflammatory processes was observed in 19% of cases in the main group and in 50% of patients in the control group. The predominance of the inflammatory process in patients of the main group was observed in 13% of cases, while in patients of the control group in 31% of cases (χ2=8.13, p=0.017).
Conclusion.
The use of the medication Superlimf after vestibuloplasty indicates the dominance of regeneration processes over inflammation processes in the operated area. The medication Superlimf in the form of alginate plates for the oral cavity can be recommended in order to optimize the regeneration of peri-implant soft tissues after vestibuloplasty.

Key words:

dental implantation, peri-implant soft tissue barrier, mucogingival integration, attached gum, vestibuloplasty

For Citation

[1]
Lysov A.D., Postnikov M.A., Chigarina S.E., Alesheva M.D., Lysova V.A. The application of the medication Superlimf in the peri-implant area after vestibuloplasty. Clinical Dentistry (Russia).  2024; 27 (1): 40—48. DOI: 10.37988/1811-153X_2024_1_40

References

  1. Bondarets A.Iu., Gunenkova I.V., Samoĭlova N.V. Some aspects of terminology, classification and incidence of hypodontia. Stomatology. 2014; 2: 47—51 (In Russian). eLIBRARY ID: 21568146
  2. Mustafaeva F.M. Comprehensive prevention and prognosis of dental implantation complications: master’s thesis. Nalchik: Kabardino-Balkarian State University, 2017. 141 p. (In Russian).
  3. Park K.B., Park S.J., Dinu C., Engelschalk M., Kwon M., Linkevicius T., Cargallo-Albiol J., Han T. New suggestions of success criteria for dental implants: a comprehensive review&update. International Journal of Future Dentistry. 2021; 1 (2): 92—98. https://imegagen.com/download/17769/
  4. Vatėnas I., Linkevičius T. The use of the connective tissue graft from the palate for vertical soft tissue augmentation during submerged dental implant placement: A case series. Clin Exp Dent Res. 2022; 8 (5): 1103—1108. PMID: 35789972
  5. Linkevicius T., Puisys A., Linkevicius R., Alkimavicius J., Gineviciute E., Linkeviciene L. The influence of submerged healing abutment or subcrestal implant placement on soft tissue thickness and crestal bone stability. A 2-year randomized clinical trial. Clin Implant Dent Relat Res. 2020; 22 (4): 497—506. PMID: 32250061
  6. Linkevicius T., Puisys A., Linkeviciene L., Peciuliene V., Schlee M. Crestal bone stability around implants with horizontally matching connection after soft tissue thickening: A prospective clinical trial. Clin Implant Dent Relat Res. 2015; 17 (3): 497—508. PMID: 24103157
  7. Abdallah M.N., Badran Z., Ciobanu O., Hamdan N., Tamimi F. Strategies for optimizing the soft tissue seal around osseointegrated implants. Adv Healthc Mater. 2017; 6 (20): 1700549. PMID: 28960892
  8. Suárez-López Del Amo F., Lin G.H., Monje A., Galindo-Moreno P., Wang H.L. Influence of soft tissue thickness on peri-implant marginal bone loss: A systematic review and meta-analysis. J Periodontol. 2016; 87 (6): 690—9. PMID: 26777766
  9. Lysov A., Saadoun A.P. Periodontal, functional, and esthetic integration of peri-implant soft tissue: WHS Concept. J Oral Implantol. 2022; 48 (1): S1-S8. PMID: 34965296
  10. Durnovo E.A., Galkina E.S., Tarakanova V.A. Kinetics of mucosal blood flow in 3D modeling of the gingival contour around dental implants after bone reconstruction of the alveolar ridge in the lateral part of the jaws. Stomatology. 2023; 2: 25—32 (In Russian). eLIBRARY ID: 53767238
  11. Rajalakshmi S.B., Arvina R., Thiyaneswaran N. Correlation between width of keratinized gingiva and peri-implant health status in mandibular first molar A cross sectional study. Journal of Pharmaceutical Negative Results. 2022; 13 (9): 8746—8752.
  12. Ramanauskaite A., Schwarz F., Sader R. Influence of width of keratinized tissue on the prevalence of peri-implant diseases: A systematic review and meta-analysis. Clin Oral Implants Res. 2022; 33 Suppl 23: 8—31. PMID: 35763022
  13. Monje A., Blasi G. Significance of keratinized mucosa/gingiva on peri-implant and adjacent periodontal conditions in erratic maintenance compliers. J Periodontol. 2019; 90 (5): 445—453. PMID: 30461016
  14. Schwarz F., Becker J., Civale S., Sahin D., Iglhaut T., Iglhaut G. Influence of the width of keratinized tissue on the development and resolution of experimental peri-implant mucositis lesions in humans. Clin Oral Implants Res. 2018; 29 (6): 576—582. PMID: 29693279
  15. Orekhova L.Yu., Tets V.V., Ulitovskiy S.B., Leontyev A.A., Domorad A.A., Yakovleva O.M. Use of adhesive balm Asepta the treatment of inflammatory periodontal diseases. Parodontologiya. 2007; 3 (44): 64—68 (In Russian). eLIBRARY ID: 9924164
  16. Pestrikova T.Yu., Astafyeva A.S., Yurasova E.A. Efficacy of local cytokine therapy in the complex treatment of HPV-associated cervicitis. Gynecology, Obstetrics and Perinatology. 2022; 2: 41—48 (In Russian). eLIBRARY ID: 48643813
  17. Dobrokhotova Y.E., Gankovskaya L.V., Borovkova E.I., Nugumanova O.R. Exogenous cytokine therapy in the treatment of patients with chronic endometritis. Obstetrics and Gynecology. 2021; 2: 119—127 (In Russian). eLIBRARY ID: 44746709
  18. Ovchinnikov R.I., Popova A.Yu., Vtorushina V.V., Muradyan A.A., Gamidov S.I. The use of a complex of natural antimicrobial peptides and cytokines for treatment of male infertility and chronic prostatitis. Urologiia. 2022; 2: 43—53 (In Russian). eLIBRARY ID: 48377172
  19. Ovchinnikov A.Yu., Yegiyan S.S., Akopyan L.V. Topical Cytokine Therapy in Chronic Tonsillitis. Effective pharmacotherapy (Russia). 2022; 28: 26—31 (In Russian). eLIBRARY ID: 49882181
  20. Grudyanov A.I., Fomenko E.V., Kalyuzhin O.V., Berkutova I.S. Study of the clinical complex efficacy of natural cytokines and antimicrobial peptides in the treatment of patients with inflammatory periodontal diseases. International Dental Review. 2021; 4 (97): 16—20 (In Russian). eLIBRARY ID: 47417703
  21. Grudyanov A.I., Fomenko E.V., Berkutova I.S. Clinical evaluation of Superlymph a local immunomodulator in the treatment of patients with a slight chronic generalized periodontitis. Clinical Dentistry (Russia). 2022; 1: 44—47 (In Russian). eLIBRARY ID: 48156197
  22. Proskokova S.V., Voronetskaya V.A., Enikeev A.M., Kutuzov D.N., Pirogov A.E., Bogdanova K.M. Evaluation of the effectiveness of immunomodulatory therapy in the treatment of traumatic lesions of the oral mucosa in orthodontic patients. Medical alphabet. 2023; 20: 35—37 (In Russian). eLIBRARY ID: 55862429

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Received

October 10, 2023

Accepted

January 24, 2024

Published on

March 21, 2024