DOI:

10.37988/1811-153X_2024_1_20

Use of vitamin D in the complex treatment of patients with chronic apical periodontitis

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Authors

  • T.V. Alkhazurova 1, assistant at the Therapeutic dentistry Department
    ORCID: 0009-0004-8681-2794
  • I.M. Makeeva 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department, director of the Institute of Dentistry
    ORCID: 0000-0002-7878-0452
  • L.L. Borozdkin 1, PhD in Medical Sciences, associate professor of the Maxillofacial surgery Department
    ORCID: 0000-0002-6403-2621
  • Y.V. Samokhlib 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0001-5330-5092
  • V.L. Pustovoit 1, 5th year student
    ORCID: 0009-0000-8672-6803
  • A.Yu. Turkina 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0003-2852-0051
  • 1 Sechenov University, 119991, Moscow, Russia

Abstract

The aim of the study was to clinically evaluate the effectiveness of vitamin D administration in the treatment of chronic apical periodontitis.
Materials and methods.
In 128 patients aged from 20 to 80 years with chronic apical periodontitis the concentration of vitamin D in blood plasma was measured before treatment. According to the results of biochemical analysis, the patients were divided into 3 groups: I — 42 people with vitamin D deficiency (less than 30 ng/mL), who were additionally prescribed cholecalciferol; II — 40 people with vitamin D deficiency, without correction of its level during treatment; III — 46 patients with normal vitamin D level. Before treatment and after 3, 6, 12 and 18 months the concentration of vitamin D in blood serum and the size of foci of destruction of periapical tissues of teeth according to CBCT were measured.
Results.
 The time of complete healing in groups I and III was on average 21.4 and 19.9 months shorter than in group II patients with vitamin D deficiency and without vitamin D level correction during treatment (p<0.0001).
Conclusion.
Inclusion of vitamin D in therapy increases the intensity of bone metabolic processes, accelerates the rate of bone formation and leads to complete restoration of periapical tissues.

Key words:

vitamin D, endodontic treatment, chronic apical periodontitis, CBCT, bone tissue destruction, remodeling

For Citation

[1]
Alkhazurova T.V., Makeeva I.M., Borozdkin L.L., Samokhlib Y.V., Pustovoit V.L., Turkina A.Yu. Use of vitamin D in the complex treatment of patients with chronic apical periodontitis. Clinical Dentistry (Russia).  2024; 27 (1): 20—24. DOI: 10.37988/1811-153X_2024_1_20

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Received

November 19, 2023

Accepted

February 26, 2024

Published on

March 21, 2024