DOI:

10.37988/1811-153X_2023_4_128

Features of ozone therapy effect on the microbiota composition of the surface of erosive and ulcerative elements in patients with the oral lichen planus

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Authors

  • I.N. Usmanova 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-1781-0291
  • I.A. Lakman 2, PhD in Engineering, assistant professor of the Biomedical engineering Department, head of the Scientific Lab for the study of socio-economic problems of regions
    ORCID: 0000-0001-9876-9202
  • O.A. Guryevskaya 3, dentist
    ORCID: 0000-0003-4580-9826
  • L.P. Gerasimova 1, PhD in Medical Sciences, Head of the Department of Therapeutic Dentistry
    ORCID: 0000-0002-1145-6500
  • M.M. Tuigunov 1, PhD in Medical Sciences, full professor of the Microbiology and virology Department
    ORCID: 0000-0002-5473-2034
  • R.F. Khusnarizanova 1, PhD in Biology, assistant professor of the Microbiology and virology Department
    ORCID: 0000-0002-1001-9587
  • J.L. Bortsova 1, PhD in Biology, assistant professor of the Fundamental and applied microbiology Department
    ORCID: 0000-0002-5839-9793
  • T.N. Titova 1, PhD in Biology, assistant professor of the Fundamental and applied microbiology Department
    ORCID: 0000-0002-1609-3091
  • V.O. Senina 1, postgraduate at the Therapeutic dentistry Department, assistant at the Surgical dentistry Department
    ORCID: 0000-0002-5593-085X
  • 1 Bashkir State Medical University, 450008, Ufa, Russia
  • 2 Ufa University of Science and Technology, 450076, Ufa, Russia
  • 3 Dental clinic “Elite”, 644012, Omsk, Russia

Abstract

The goal of this paper is to assess and substantiate the effectiveness of the effect of ozone therapy and as part of local treatment of erosive and ulcerative form of the lichen planus in the oral cavity mucosa lining.
Materials and methods.
86 adult patients with confirmed lichen planus in the oral cavity mucosa lining (L43.82) on the buccal region were included in the research. Depending on the severity of candidiasis and the method of treatment, the patients were divided into 4 groups. Group I and II included 46 patients with mild candidiasis (<4 lg CFU Candida spp.), and group III and IV included 40 patients with moderate oral candidiasis (≥4 lg CFU Candida spp.). Group I and III patients were treated with Hy + Al Gel (0.2% sodium hyaluronate and 0.5% sucralfate), ozone therapy, Prednisolone, and keratoplasty (a self-dissolving patch with povidone and tocopheryl acetate).
Results.
There were no statistically significant differences in the severity of clinical manifestations between the groups with the erosive and ulcerative form of the lichen planus. In the process of local treatment in the group of patients with moderate candidiasis who obtained a complex consisting of ozone therapy, corticosteroids, antibacterial agents and keratoplasty, elimination of Candida spp. (χ2=3.46, p=0.063), decontamination of Streptococcus spp. (χ2=9.446, p=0.003), was observed in the microbiota of the surface of epithelializing erosive and ulcerative elements, and for patients with mild candidiasis, decontamination of Streptococcus spp. (χ2=7.03, p=0.009) and L. buccalis (χ2=3.27, p=0.071) was observed as compared to the groups obtaining complex local treatment according to federal clinical guidelines.
Conclusion.
Inclusion in the complex of local treatment of antiseptic treatment of the erosive and ulcerative element surface with 0.2% hyaluronic acid gel (Hy + Al Gel) before treatment of erosions surface with ozone therapy, alternate single applications of 0.5% Prednisolone ointment, closure of the erosive and ulcerative element surface with Ora-Aid patch containing keratoplastic in its composition promotes a pronounced synergy of antiseptic, antimicrobial, and antifungal effect.

Key words:

lichen planus, erosive and ulcerative form, microbiota, ozone therapy, corticosteroids, hyaluronic acid, Ora-Aid

For Citation

[1]
Usmanova I.N., Lakman I.A., Guryevskaya O.A., Gerasimova L.P., Tuigunov M.M., Khusnarizanova R.F., Bortsova J.L., Titova T.N., Senina V.O. Features of ozone therapy effect on the microbiota composition of the surface of erosive and ulcerative elements in patients with the oral lichen planus. Clinical Dentistry (Russia).  2024; 26 (4): 128—133. DOI: 10.37988/1811-153X_2023_4_128

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Received

October 12, 2023

Accepted

December 2, 2023

Published on

January 16, 2024