Peculiarities of the effect of various application adhesives in the complex of topical treatment of recurrent aphth of the oral cavity in patients on the background of clinical manifestations of classical and indirect hypersecretary diseases of the gastrointestinal tract

Abstract

The purpose of this work was to evaluate and substantiate the effectiveness of the influence of various adhesive agents and a diode laser in the complex of local treatment of erosive and ulcerative lesions of the oral mucosa against the background of clinical manifestations of classical and mediated hypersecretory diseases of the gastrointestinal tract.
Materials and methods.
A comprehensive clinical and laboratory study involved 58 patients of young working age with erosive and ulcerative lesions of the oral mucosa (K12.0). The examination included an assessment of the condition of the mucous membrane of the vestibule and the oral cavity itself, the level of hygiene according to Green—Vermillion (1964). In samples of the oral fluid using universal indicator, the acidity of the oral fluid was assessed. A qualitative and quantitative study of the composition of the microbiota obtained from the plaque surface from erosive and ulcerative elements was carried out by seeding on special differential diagnostic media of the HiCrome series. To assess the rate of epithelialization in days, the Kaplan—Meier method of multiplier estimates, and the Gehan-Wilcoxon test were used.
Results.
The influence of local treatment in all persons with the presence of aphthae contributed to the removal of acute alternative inflammation, regression of complaints and symptoms (χ2=0.0, p=1.0), normalization of the hygienic state of the oral cavity (Z=0.88, p=0.379), pH of the oral fluid (Z=0.64, p=0.522), composition of the resident microbiota of the surface of the aphthae in the stage of epithelialization during the entire period of clinical observation. According to the Gehan—Wilcoxon test, there are statistically significant differences in the rate of aphthae epithelialization depending on the presence of hypersecretory diseases of the gastrointestinal tract (p<0.001).
Conclusion.
Inclusion in the scheme of local treatment of antiseptic treatment of the surface of erosive and ulcerative elements with Holisal gel (choline salicylate, cetalkonium chloride) and exposure to a diode laser, as well as alternate applications of agents with adhesiveness — a powdered form of platelet autologous plasma and Holisal gel, contributed to the regression of complaints and symptoms to 4.5±0.5 and 5.5±0.4 days of observation, stabilization of the hygienic state of the oral cavity and pH of the oral fluid, normalization of the composition of the microbiota of the epithelium surface due to a pronounced anti-inflammatory, antimicrobial, antifungal, epithelial and regenerating action.