DOI:

10.37988/1811-153X_2023_1_158

Nanotechnology in dentistry: hydrosols of metal nanoparticles are promising antibiotics

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Authors

  • S.Yu. Ivanov 1, 2, associate member of the Russian Academy of Sciences, Grand PhD in Medical Sciences, professor of the Oral and maxillofacial surgery Department; head of Maxillofacial Surgery Department.
    ORCID: 0000-0001-5458-0192
  • Ya.N. Karasenkov 3, PhD in Medical Sciences, chief medical officer
    ORCID: 0000-0002-9658-3700
  • N.V. Latuta 1, PhD Medical Sciences, associate professor of the Department of Pediatric Dentistry, Preventive Dentistry and Orthodontics
    ORCID: 0000-0002-6754-0314
  • V.V. Dzhatdaev 4, dental surgeon
    ORCID: 0000-0002-0338-4906
  • E.A. Egorov 5, doctor
    ORCID: 0000-0002-3519-3864
  • E.K. Tarasova 5, doctor
    ORCID: 0000-0002-6715-2071
  • E.V. Kozlova 1, dentist at the Therapeutic Division
    ORCID: 0000-0002-3722-2120
  • P.A. Kozlov 1, maxillofacial surgeon at the Maxillofacial Surgery Clinic
    ORCID: 0000-0001-5554-7001
  • 1 Sechenov University, 119991, Moscow, Russia
  • 2 RUDN University, 117198, Moscow, Russia
  • 3 “Rosdent” Dental Clinic, 119192, Moscow, Russia
  • 4 “President” Dental Clinic, 117449, Moscow, Russia
  • 5 “Aesthetics” Dental Clinic, 141191, Fryazino, Russia

Abstract

Infectious diseases are the leading cause of morbidity and mortality in the human population. The causative agent for the development of multidrug-resistant bacteria is one of the most acute health problems. The rise in antibiotic resistance is also associated with the lack of new antimicrobials. Purpose: to obtain hydro/alcohol sols of metal nanoparticles with long-term bactericidal action. >. Hydro/alcohol sols were obtained in distilled water/alcohol by arc electric discharge passing through two electrodes: Ag, TiO2, Fe3O4, VO2, CoO, TaO2, ZnO, CuO, a combination of TiO2 + Al2O3 + MoO2. The studies hydrosols of metal nanoparticles CuO, TaO2, Fe3O4, TiO2, Ag, ZnO were carried out on cultures of microorganisms S. aureus, P. aeruginosa, P. vulgaris, S. tiphimurium, C. albicans, E. coli. The hydrosols CuO, TaO2, Fe3O4, TiO2, ZnO contain cetylpyridinium chloride (CPC) as a stabilizer — 0.07%, in the hydrosol Ag the stabilizer is sodium citrate (E331). The observation period is 14 days. >. Metal hydrosols are bactericidally active in a whole solution of 2.4—13.88 mg/L. >. A method for obtaining hydro/alcohol sols of nanodispersed systems of metals Ag, TiO2, Fe3O4, VO2, CoO, TaO2, ZnO, CuO, a combined solution of TiO2, Al2O3, MoO2 has been developed. Hydrosols CuO, TaO2, Fe3O4, TiO2, ZnO, demonstrate long-term bactericidal activity for 14 days.

Key words:

nanoparticles, minimal bactericidal activity, hydrosols, alcohol sols

For Citation

[1]
Ivanov S.Yu., Karasenkov Ya.N., Latuta N.V., Dzhatdaev V.V., Egorov E.A., Tarasova E.K., Kozlova E.V., Kozlov P.A. Nanotechnology in dentistry: hydrosols of metal nanoparticles are promising antibiotics. Clinical Dentistry (Russia).  2023; 26 (1): 158—163. DOI: 10.37988/1811-153X_2023_1_158

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Received

July 11, 2022

Accepted

February 8, 2023

Published on

March 22, 2023