DOI:

10.37988/1811-153X_2023_1_92

Photodynamic therapy with curcumin-based photosensitizer for treatment of gingivitis

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Authors

  • I.Yu. Chausskaya 1, PhD in Medical Sciences, associate professor of the Maxillofacial and plastic surgery Department
    ORCID: 0000-0001-9674-1919
  • D.E. Nikogosova 1, senior laboratory technician at the Maxillofacial and plastic surgery Department
    ORCID: 0000-0003-3777-511X
  • E.I. Kozlikina 2, 3, engineer at the Laser biospectroscopy Lab of the Light-induced surface phenomena Division; Graduate student at the Laser Micro-Nano and Biotechnology Department
    ORCID: 0000-0002-4080-4041
  • D.I. Meliev 1, senior laboratory technician at the Maxillofacial and plastic surgery Department
    ORCID: 0000-0001-8034-7618
  • M.S. Amrieva 1, postgraduate at the Maxillofacial and plastic surgery Department
    ORCID: 0000-0003-1981-6002
  • A.Yu. Drobyshev 1, PhD in Medical Sciences, full professor of the Maxillofacial and plastic surgery Department
    ORCID: 0000-0002-1710-6923
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia
  • 2 Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991, Moscow, Russia
  • 3 Moscow Engineering Physics Institute, 115409, Moscow, Russia

Abstract

Gingivitis is a disease most often occurs in dental practice. The search for novel prevention and treatment approaches is a relevant problem due to the high prevalence of gingivitis. Medications based on curcumin have anti-inflammatory, antioxidant, and photosensitizing properties. Photodynamic therapy (PDT) with curcumin photosensitizer (PS) is a non-invasive perspective treatment option. Clinical outcomes of PDT and fluorescence navigation with novel PS are reported in the present study. The clinical trial involved 5 patients with chronic catarrhal gingivitis (CCG). The data showed accumulation of PS in pathological areas in high concentrations. Each patient received 1 PDT procedure with various energy doses. The PS photobleaching rate ranged from 76 to 85%. Follow-up of the patients was one months. Resolution of symptoms and complete regression of pathological sites were noted at the control examinations. Therefore, controlled PDT with curcumin-based PS led to recovery in the whole group of patients and can be considered as a perspective method of treatment.

Key words:

photodynamic therapy, photosensitizer, curcumin, fluorescence diagnostics, gingivitis

For Citation

[1]
Chausskaya I.Yu., Nikogosova D.E., Kozlikina E.I., Meliev D.I., Amrieva M.S., Drobyshev A.Yu. Photodynamic therapy with curcumin-based photosensitizer for treatment of gingivitis. Clinical Dentistry (Russia).  2023; 26 (1): 92—97. DOI: 10.37988/1811-153X_2023_1_92

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Received

December 23, 2022

Accepted

February 13, 2023

Published on

March 22, 2023