DOI:

10.37988/1811-153X_2023_1_68

Assessment of microhemodynamics in periodontal tissues during treatment of chronic generalized periodontitis with photodynamic therapy

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Authors

  • F.F. Losev 1, PhD in Medical Sciences, full professor, director
    ORCID: 0000-0002-9448-9614
  • E.K. Krechina 1, PhD in Medical Sciences, full professor of the Functional diagnostics Department
    ORCID: 0000-0003-2936-0707
  • E.V. Ivanova 2, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-6330-6942
  • E.Yu. Kuksa 1, PhD candidate at the Functional diagnostics Department
    ORCID: 0000-0001-7628-8678
  • 1 Central Research Institute of Dental and Maxillofacial Surgery, 119021, Moscow, Russia
  • 2 Russian Medical Academy of Continuous Professional Education, 125993, Moscow, Russia

Abstract

The aim of the work was to study the effectiveness of photodynamic therapy (PDT) according to the data of microhemodynamics and oxygen metabolism in periodontal tissues during the treatment of moderate chronic generalized periodontitis (CGP). >. Clinical and functional examination and treatment of moderate CGP were carried out in 60 people (24 men and 36 women) aged 35 to 50 years (42.5±2.7 years) without somatic pathology and with orthognathic bite. The patients were divided into 2 equal groups according to the type of treatment: I (main), whose patients received PDT with 1% Geleofor gel (660 nm, 2.5 W/cm2, 8 min, 4 sessions) after oral hygiene, plaque removal, selective grinding of teeth, curettage of periodontal pockets and training in rational hygiene; II (control), whose patients received standard treatment. The hemodynamics in the periodontal tissues with determination of systolic, average and diastolic blood flow, systolic and average volumetric blood flow, pulsatility index and peripheral blood flow resistance index were studied by ultrasonic dopplerography (USDG). Oxygenation in the periodontal tissues was also studied by optical tissue oximetry with measurement of oxygenation index, specific oxygen consumption and perfusion oxygen saturation index. All measurements were made before and after treatment as well as after 6 and 12 months. >. According to USDG data, linear and volumetric blood flow velocities increased by 50—200% after treatment, which indicated normalization of microhemodynamics, which remained after 6 and 12 months in group I. In group I after PDT, the levels of perfusion saturation and specific oxygen consumption increased by 30 and 19%, respectively, and did not fall within 6 and 12 months. In group II after treatment, microhemodynamics increased less significantly — by 30—70%, the achieved indices were maintained up to 6 months, and in 12 months they decreased to their baseline levels. Improvement of oxygen metabolism was less significant — by 10—38%, and the parameters restored to their baseline values in 6 and 12 months. >. The application of PDT with 1% gel Geleofor activates microhemodynamics and oxygen metabolism processes.

Key words:

periodontitis, microhemodynamics, oxygenation, LED radiation, PDT

For Citation

[1]
Losev F.F., Krechina E.K., Ivanova E.V., Kuksa E.Yu. Assessment of microhemodynamics in periodontal tissues during treatment of chronic generalized periodontitis with photodynamic therapy. Clinical Dentistry (Russia).  2023; 26 (1): 68—72. DOI: 10.37988/1811-153X_2023_1_68

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Received

February 11, 2023

Accepted

February 15, 2023

Published on

March 22, 2023