DOI:

10.37988/1811-153X_2022_4_119

Electrokinetic indices of erythrocytes in assessing the effectiveness of NO-therapy in elder patients with odontogenic phlegmon

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Authors

  • B.Ya. Agadzhanyan 1, postgraduate at the the Surgical Dentistry and Implantology Department
    ORCID: 0000-0001-7353-153X
  • M.A. Amkhadova 1, PhD in Medical Sciences, full professor of the Surgical Dentistry and Implantology Department
    ORCID: 0000-0002-9105-0796
  • I.A. Vasilenko 1, 2, PhD in Medical Sciences, full professor, head of the Biomedical research Laboratory; professor of the Inorganic and analytical Chemistry Department
    ORCID: 0000-0002-6374-9786
  • 1 Moscow Regional Research Clinical Institute (MONIKI), 129110, Moscow, Russia
  • 2 Kosygin University, 115035, Moscow, Russia

Abstract

Timely diagnostics of odontogenic purulent-inflammatory complications after dental surgery, prognosis of their course and evaluation of treatment efficacy remains an actual problem of dentistry. The risk group consists of persons older than 65 years old, in whom moderate or severe forms, atypical prolonged course of the disease and delayed regeneration are more often manifested. The aim of the study to evaluate he efficacy of exogenous nitrogen therapy in elderly and senile patients with odontogenic phlegmons using the express method of peripheral blood erythrocyte microelectrophoresis. >. We examined 34 patients with odontogenic phlegmon aged from 67 to 78 years. At the stage of postoperative treatment 18 patients additionally underwent NO-therapy procedures, 16 patients received only conventional treatment. Electrokinetic indices of erythrocytes were used as criteria for evaluating the effectiveness of therapy: mean value of oscillation amplitude; fraction of mobile cells. >. In patients with odontogenic phlegmon before treatment the proportion of mobile erythrocytes was 78—81% (vs 96% in the control), and the amplitude of their oscillations decreased more than 2-fold. After the NO-therapy sessions, the electrokinetic parameters practically corresponded to the normal values. In the group with conventional therapy, the results were less satisfactory. >. NO-therapy is a pathogenetically oriented method of treatment in patients with odontogenic phlegmon, which corrects disturbances of cellular homeostasis and the clinical course of the purulent process. Electrokinetic parameters of erythrocytes can be considered as informative and objective indicators of the effectiveness of the therapy when monitoring the patient’s condition.

Key words:

exogenous nitric oxide, NO-therapy, odontogenic phlegmons, erythrocytes, electrophoretic mobility, elderly patient

For Citation

[1]
Agadzhanyan B.Ya., Amkhadova M.A., Vasilenko I.A. Electrokinetic indices of erythrocytes in assessing the effectiveness of NO-therapy in elder patients with odontogenic phlegmon. Clinical Dentistry (Russia).  2022; 25 (4): 119—123. DOI: 10.37988/1811-153X_2022_4_119

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Received

October 1, 2022

Accepted

November 3, 2022

Published on

December 21, 2022