DOI:

10.37988/1811-153X_2022_4_34

Characteristics of the state of some local oral immunity factors and the possibility of their correction in patients with diseases of periodontal tissues

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Authors

  • L.P. Kiselnikova 1, PhD in Medical Sciences, full professor of the Paediatric dentistry Department
    ORCID: 0000-0003-2095-9473
  • A.A. Gutnik 1, assistant at the Paediatric dentistry Department
  • I.G. Danilova 2, PhD in Biology, full professor of the Medical biochemistry and biophysics Department
    ORCID: 0000-0001-6841-1197
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia
  • 2 Ural Federal University, 620002, Yekaterinburg, Russia

Abstract

Periodontal diseases are one of the hot topics in current dentistry. According to a number of authors, the prevalence of periodontal tissue diseases among children varies depending on age and increases towards the beginning of adolescence. Along with the microbial factor, the nature of the course of periodontal diseases is affected by the state of local factors of immunological protection, the presence of somatic pathology. In adult patients and children with periodontal diseases, there is an imbalance in the components of local immunological protection of the oral cavity — immunoglobulins, cytokines. Moreover, in patients with type 1 diabetes, these disorders are more pronounced. Along with the traditional methods of treating periodontal tissue diseases, new approaches to the treatment of periodontal diseases are emerging, based on the local effects of cytokines in the oral cavity. This technique is relevant and shows positive results in dental practice. Conclusions: the analysis of studies demonstrating the positive effect of the use of drugs based on the natural complex of cytokines in dental practice indicates the prospects for the development of this area in the treatment of inflammatory periodontal diseases.

Key words:

local immunity, cytokines, diabetes mellitus, periodontal disease

For Citation

[1]
Kiselnikova L.P., Gutnik A.A., Danilova I.G. Characteristics of the state of some local oral immunity factors and the possibility of their correction in patients with diseases of periodontal tissues. Clinical Dentistry (Russia).  2022; 25 (4): 34—43. DOI: 10.37988/1811-153X_2022_4_34

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Received

August 30, 2022

Accepted

October 24, 2022

Published on

December 21, 2022