DOI:

10.37988/1811-153X_2022_2_50

Boron and Dimephosphon efficacy of peri-implantitis therapy according to bone mineral density, mineral metabolism, and bone remodeling markers

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Authors

  • A.V. Shumskij 1, PhD in Medical Sciences, full professor, chief physician, executive officer
    ORCID: 0000-0002-8055-1958
  • A.N. Kizim 2, top-tier dentist, director
  • O.N. Pavlova 3, PhD in Biology, full professor of the Physiology, life safety and disaster medicine Department
    ORCID: 0000-0002-8055-1958
  • O.N. Gulenko 3, PhD in Biology, associate professor of the Physiology, life safety and disaster medicine Department
    ORCID: 0000-0001-6338-7095
  • 1 Prof. Shumskiy Medical and Training Centre, 443001, Samara, Russia
  • 2 Dr. Kizim Dental and basal implant Centre, 430011, Saransk, Russia
  • 3 Samara State Medical University, 443001, Samara, Russia

Abstract

Peri-implantitis is an inflammatory process in the gingival cuff area and in a limited area of the implant/bone tissue, which is caused by a wide range of unfavorable factors. There are many described methods of prevention of complications after dental implantation and methods of surgical and non-surgical treatment, but a universal approach, guaranteeing the success of the cure, has not yet been found. Dimephosphone and boron medications use and their combination may become a promising way for prevention and treatment of peri-implantitis.
Materials and methods.
The study involved 120 participants (66 women and 54 men from 30 to 60 years old) having diagnosed “peri-implantitis” divided into 4 equal groups by the treatment way: no treatment (control), intake of organic boron as calcium borogluconate (group I), treatment with dimefosphone (group II) and the combined use of boron and dimefosphone (group III). Bone mineral density (BMD) was measured before and after treatment by ultrasound densitometer, mineral metabolism parameters (Ca, Mg, P) and bone tissue remodeling markers (β-CTX, TSF, sRANKL, OPG and sclerostin) were determined.
Results.
Before treatment the proportion of patients with physiological level of BMD in the studied groups ranged from 35.0 to 47.5%; with reduced BMD - from 42.5 to 57.5%, and with significant reduction of BMD - from 5 to 10%. After treatment percentage of patients had physiological level of BMD varied from 37.5 to 52.5%; with reduced BMD - from 42.5 to 57.5%, and with significant reduction of BMD - from 2.5 to 7.5%. Calcium concentration in Group I increased by 5.15%, magnesium by 19.2%, and phosphorus by 12.6% over 30 days of treatment. In group II the calcium concentration changed insignificantly, while magnesium and phosphorus increased by 6.8% and 7.1%, respectively. Complex therapy with boron and demiphosphon in group III led to increasing of calcium concentration in plasma by 7.8%, magnesium - by 25.9%, phosphorus - by 23.9%. Regarding the markers of bone remodeling in the blood plasma of the patients before and after 30 days of peri-implantitis therapy the similar tendency was observed.
Conclusions.
Therapy with boron, dimephosphon and complex application of boron and dimephosphon preparations contribute to normalization of bone tissue mineral density, mineral exchange and markers of bone remodeling and the complex therapy is the most effective.

Key words:

peri-implantitis, ultrasonometry, bone mineral density, mineral metabolism, remodeling markers

For Citation

[1]
Shumskij A.V., Kizim A.N., Pavlova O.N., Gulenko O.N. Boron and Dimephosphon efficacy of peri-implantitis therapy according to bone mineral density, mineral metabolism, and bone remodeling markers. Clinical Dentistry (Russia).  2022; 25 (2): 50—56. DOI: 10.37988/1811-153X_2022_2_50

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Received

March 23, 2022

Accepted

May 26, 2022

Published on

June 1, 2022