Cytokine status of the oral fluid in periodontitis in patients with a survey of coronavirus infection

Abstract

On the development of the development of dentistry, periodontal diseases are an identified problem and occupy a leading position in the special dental diseases of countries in different countries. COVID-19 and periodontitis measure the proportion of the cytokine status of the oral fluid, therefore, the question of the calorie content of studying the level of salivary cytokines in people with periodontal diseases who have had a coronavirus infection is relevant, since in the case of studying the COVID-19 process, data were found that allow for accurate interpretation in relation to periodontitis. The aim of the study is to determine the immunological parameters of the oral fluid of patients with periodontitis who are not affected by coronavirus infection.
Materials and methods.
The study involved 100 people: 40 healthy participants, 30 patients with chronic periodontitis, 40 patients with periodontitis who had COVID-19. The fact of a coronavirus infection was established on the basis of anamnesis data and an enzyme immunoassay for IgG antibodies to the SARS-CoV-2 S protein. The level of cytokines (IL-2, IL-4, IL-6, IL-8) is determined by enzyme-linked immunosorbent assay.
Results.
Apparently healthy participants have lower levels of all cytokines. Patients with periodontitis who have recovered from COVID-19 require higher levels of IL-6 and IL-8 (by 2 pg/ml and 23 249 pg/ml, respectively) compared to patients with periodontitis who have not had a coronavirus infection. However, the difference in the concentration of IL-2 and IL-4 (by 0.3 pg/ml and 2.6 pg/ml, respectively) was not statistically significant. No difference was found at the level of IL-2 and IL-4.
Conclusion.
To assess the cytokine status of the oral fluid in patients with periodontitis, the determination of IL-2 and IL-4 is most often used due to the fact that their level is relatively high in the presence of a coronavirus infection.