Unstabilized hyaluronic acid in patients with maxillary alveolar atrophy, mandibular alveolar atrophy

Authors

  • A.M. Sipkin 1, PhD in Medical Sciences, head of the Maxillofacial surgery and hospital surgical dentistry Department
    ORCID: 0000-0001-8287-741X
  • A.D. Chenosova 1, PhD in Medical Sciences, researcher at the Maxillofacial surgery Division
    ORCID: 0000-0003-4217-6736
  • T.N. Modina 2, PhD in Medical Sciences, full professor of the Maxillofacial dentistry Department
    ORCID: 0000-0002-2063-9464
  • S.A. Epifanov 2, PhD in Medical Sciences, head of the Maxillofacial dentistry Department
    ORCID: 0000-0001-6247-957X
  • 1 Moscow Regional Research Clinical Institute (MONIKI), 129110, Moscow, Russia
  • 2 Pirogov National Medical & Surgical Center, 105203, Moscow, Russia

Abstract

From February 2018 to the present, a clinical examination and treatment of 60 patients aged 20 to 72 years with partial secondary tooth loss and alveolar atrophy, who underwent surgery to restore the volume bone structure with the use of auto-shavings, and xenogenic osteoplastic material Bio-oss S with the addition of unstable hyaluronic. After 3—4 months, the patients underwent a control CT-scan, according to the results of which the second stage of treatment was performed — the installation of dental implants. The proposed method for remodeling the alveolar process of the upper jaw and the alveolar part of the lower jaw made it possible to reduce the rehabilitation period of patients by 2 times (patent no. 26960044 from 30.09.2019). The developed method of directed bone regeneration with the use of HA allowed to reduce the number of complications in the postoperative period in the main group of patients to 93%, and in the control group to 77%, which allows us to conclude about the safety and effectiveness of the new proposed method and provides a predictable result of recovery occlusion with using implants.

Key words:

dental implant, augmentation, hyaluronic acid, bone grafting, bone substitutes, regeneration

For Citation

[1]
Sipkin A.M., Chenosova A.D., Modina T.N., Epifanov S.A. Unstabilized hyaluronic acid in patients with maxillary alveolar atrophy, mandibular alveolar atrophy. Clinical Dentistry (Russia).  2021; 24 (3): 104—108

References

  1. Iordanishvili A.K., Veretenko E.A., Serikov A.A., Lobeyko V.V., Balin D.V. Total tooth loss in adults: age-related features of prevalence, needs in treatment and clinical picture. Kursk Scientific and Practical Bulletin “Man and His Health”.— 2015; 1: 23—32 (In Russ.). eLIBRARY ID: 23279229
  2. Muraev A.A., Gazhva Y.V., Ivashkevich S.G., Riabova V.M., Korotkova N.L., Semyonova Y.A., Metsuku I.N., Faizullin R.L., Ivanov S.Y. A novel approach to alveolar bone complex defects 3D reconstruction. Modern Technologies in Medicine. 2017; 9 (2): 37—45 (In Russ.). eLIBRARY ID: 29863595
  3. Tolstunov L., Hamrick J.F.E., Broumand V., Shilo D., Rachmiel A. Bone augmentation techniques for horizontal and vertical alveolar ridge deficiency in oral implantology. Oral Maxillofac Surg Clin North Am. 2019; 31 (2): 163—191. PMID: 30947846
  4. Gus‘kov A.V., Mitin N.E., Zimankov D.A., Mirnigmatova D.B., Grishin M.I. Dental implants: state of the question today (literature review). Clinical Dentistry (Russia). 2017; 2 (82): 32—4 (In Russ.). eLIBRARY ID: 29276232
  5. Ryzhova I.P., Pogosyan N.M. Modern approaches to the restoration of bone tissue in various types of jaw bone tissue atrophy. Eurasian Scientific Association. 2018; 12—3 (46): 177—9 (In Russ.). eLIBRARY ID: 36773559
  6. Urban I. Vertical and horizontal ridge augmentation: New perspectives. Moscow: Azbuka, 2017. 400 p. (In Russ.).
  7. Bubnov A.S., Dunaev M.V., Kitaev V.A., Matavkina M.V., Druzhinin A.E. Comparative analysis and clinical experience with osteoplastic materials materials based on non-demineralized bone collagen and artificial hydroxylapatite at the close of bone defects in ambulatory surgical dentistry. Annals of the Russian Academy of Medical Sciences. 2014; 69 (7—8): 112—20 (In Russ.). eLIBRARY ID: 21994482
  8. Esposito M., Grusovin M.G., Worthington H.V., Coulthard P. Interventions for replacing missing teeth: bone augmentation techniques for dental implant treatment. Cochrane Database Syst Rev. 2006; (1): CD003607. PMID: 16437460
  9. McAllister B.S., Haghighat K. Bone augmentation techniques. J Periodontol. 2007; 78 (3): 377—96. PMID: 17335361
  10. Kannoeva M.V., Ushakov A.I., Zoryan E.V. Clinical and morphological evaluation of the quality of the jaw bone when using osteoplastic materials in preparation for dental implantation. Russian Stomatology. 2015; 8 (3): 26—8 (In Russ.). eLIBRARY ID: 25308584
  11. Karsenty G. The genetic transformation of bone biology. Genes Dev. 1999; 13 (23): 3037—51. PMID: 10601030
  12. Tadjoedin E.S., de Lange G.L., Bronckers A.L.J.J., Lyaruu D.M., Burger E.H. Deproteinized cancellous bovine bone (Bio-Oss) as bone substitute for sinus floor elevation. A retrospective, histomorphometrical study of five cases. J Clin Periodontol. 2003; 30 (3): 261—70. PMID: 12631185
  13. Karsenty G. Genetic control of skeletal development. In: Cardew G., Goode J.A. (eds.) The molecular basis of skeletogenesis: Novartis Foundation Symposium 232. John Wiley & Sons, 2001. Pp. 6—17. DOI: 10.1002/0470846658.ch2
  14. McAllister B.S., Haghighat K. Bone augmentation techniques. J Periodontol. 2007; 78 (3): 377—96. PMID: 17335361
  15. Khojasteh A., Kheiri L., Motamedian S.R., Khoshkam V. Guided bone regeneration for the reconstruction of alveolar bone defects. Ann Maxillofac Surg. 2017; 7 (2): 263—77. PMID: 29264297
  16. Simion M., Fontana F., Rasperini G., Maiorana C. Vertical ridge augmentation by expanded-polytetrafluoroethylene membrane and a combination of intraoral autogenous bone graft and deproteinized anorganic bovine bone (Bio Oss). Clin Oral Implants Res. 2007; 18 (5): 620—9. PMID: 17877463
  17. Nefussi J.R. Biology and physiology of the implant bone site. In: Khoury F., Antoun H., Missika P. (eds.) Bone augumentation in oral implantology. Quintessense Books, 2007. Pp. 1—27.
  18. Schropp L., Wenzel A., Kostopoulos L., Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003; 23 (4): 313—23. PMID: 12956475
  19. Ballini A., Cantore S., Capodiferro S., Grassi F.R. Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects. Int J Med Sci. 2009; 6 (2): 65—71. PMID: 19277251
  20. Park J.K., Yeom J., Oh E.J., Reddy M., Kim J.Y., Cho D.W., Lim H.P., Kim N.S., Park S.W., Shin H.I., Yang D.J., Park K.B., Hahn S.K. Guided bone regeneration by poly (lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications. Acta Biomater. 2009; 5 (9): 3394—403. PMID: 19477304
  21. Sipkin A.M., Modina T.N., Chenosova A.D., Tonkikh-Podolskaya O.A. Morphological assessment of the bone structure of the alveolar process using autologous bone and xenomaterial with the addition of unstabilized hyaluronic acid. Clinical Dentistry (Russia). 2020; 2 (94): 67—72 (In Russ.). DOI: 10.37988/1811—153X_2020_2_67
  22. Stern R. Hyaluronan catabolism: a new metabolic pathway. Eur J Cell Biol. 2004; 83 (7): 317—25. PMID: 15503855
  23. Rodrigues S.V., Acharya A.B., Bhadbhade S., Thakur S.L. Hyaluronan-containing mouthwash as an adjunctive plaque-control agent. Oral Health Prev Dent. 2010; 8 (4): 389—94. PMID: 21180677
  24. Kulakov A.A., Kasparov A.S., Porfenchuk D.A. Factors affecting osteointegration and the use of early functional load to reduce the duration of treatment in dental implantation. Stomatology. 2019; 4 (98): 107—15. (In Russ.). eLIBRARY ID: 39548529.
  25. Kuo J.W. Practical aspects of hyaluronan based medical products. CRC Press, 2005. 240 p.
  26. Pilloni A., Bernard G.W. The effect of hyaluronan on mouse intramembranous osteogenesis in vitro. Cell Tissue Res. 1998; 294 (2): 323—33. PMID: 9799448
  27. Tonelli P., Duvina M., Barbato L., Biondi E., Nuti N., Brancato L., Rose G.D. Bone regeneration in dentistry. Clin Cases Miner Bone Metab. 2011; 8 (3): 24—8. PMID: 22461825
  28. Kharitonov D.Yu., Azarova Ye.A., Azarova O.A. Comparative characteristics of morphological structureosteoplasticmaterials of various origin and bone tissue of man. Scientific and Medical Bulletin of the Central Chernozem Region. 2017; 69: 3—6 (In Russ.). eLIBRARY ID: 29909643
  29. Cardaropoli D. Vertical ridge augmentation with the use of recombinant human platelet-derived growth factor-BB and bovine bone mineral: a case report. Int J Periodontics Restorative Dent. 2009; 29 (3): 289—95. PMID: 19537468
  30. Dahiya P., Kamal R. Hyaluronic acid: a boon in periodontal therapy. N Am J Med Sci. 2013; 5 (5): 309—15. PMID: 23814761

Received

July 20, 2021

Accepted

July 24, 2021

Published on

September 1, 2021