DOI:

10.37988/1811-153X_2021_1_46

Topical aspects of the chronic periodontitis immunopathogenesis (review)

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Authors

  • I.I. Antonov 1, postgraduate at the Oral and maxillofacial surgery Department
    ORCID: 0000-0002-2325-9010
  • V.P. Mudrov 2, 3, PhD in Medical sciences, Laboratory physician; assistant at the Medical biochemistry and immunopathology Department
    ORCID: 0000-0003-1129-8335
  • V.N. Nelyubin 4, PhD in Medical Sciences, leading researcher of the Medico-dental research Institute
    ORCID: 0000-0002-3001-9939
  • A.A. Muraev 1, PhD in Medical Sciences, full professor of the Oral and maxillofacial surgery Department
    ORCID: 0000-0003-3982-5512
  • 1 RUDN University, 117198, Moscow, Russia
  • 2 9th Medical and diagnostic Center of Russian Ministry of Defense, Moscow, Russia
  • 3 Russian Medical Academy of Continuous Professional Education, 125993, Moscow, Russia
  • 4 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

The research analysis of a number of Russian and foreign authors devoted to the study of immunopathogenesis of chronic periodontitis is presented in this study. Periodontal disease is one of the leading problems of modern dentistry. Their importance as a medical problem is determined by the high prevalence of various forms of periodontal disease in the world. Periodontitis is characterized mainly by chronic course and in the absence of timely treatment leads to such serious consequences, such as the formation of a huge focus of odontogenic infection, weakening of body reactivity, loss of teeth and alveolar bone atrophy. In 2016, serious periodontal disease, which can lead to tooth loss, became the 11th most important disease in the world. The high prevalence and constant increase in the incidence of periodontal disease among the population, the difficulties of prevention and treatment of this disease maintain a constant scientific and practical interest in finding new approaches to solving the problem. Literature data on the immunological reactivity in periodontal disease are extremely diverse and contradictory, which is noted by many domestic and foreign researchers. This can be explained by the fact that the immunological reactivity of periodontitis patients is variable: it depends on the degree of severity, phase of the disease, age and genetic predisposition of the patient, type of inflammatory reaction and a number of other circumstances. The purpose of this review was to study the current understanding of the immunopathogenesis of chronic periodontitis in terms of a whole complex of etiological pathogens.
Materials and methods.
A literature search was conducted for PubMed (www.ncbi.nlm.nih.gov), eLibrary (elibrary.ru) ScienceDirect (www.sciencedirect.com).
Results.
As a result of the analysis of the literature, the main etiological factor recognized by most authors is infectious agents: not only bacteria, but also viruses, fungi and their interaction in the process of immunopathogenesis of chronic periodontitis, as well as the immune response of the host outstrips the intensity of periodontitis flow and severity of periodontal tissue destruction. Opinion. Understanding the processes of the immune response, the formation and progression of apical periodontitis, and the identification of biomarkers of inflammation can contribute to increased knowledge of pathogenetic mechanisms, improved diagnosis, and support for various therapeutic strategies.
Conclusions.
Research on viral, fungal and bacterial periodontal infections will help to understand the clinical and biological features of periodontitis and to formulate new strategies to combat the disease. Identification and quantitative evaluation of periodontal pathogens may have a prognostic value.

Key words:

immunopathogenesis of periodontitis, periodontal diagnostics, periodontal immunology, periodontal local immunity, periodontal pathogen

For Citation

[1]
Antonov I.I., Mudrov V.P., Nelyubin V.N., Muraev A.A. Topical aspects of the chronic periodontitis immunopathogenesis (review). Clinical Dentistry (Russia).  2021; 1 (97): 46—58. DOI: 10.37988/1811-153X_2021_1_46

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March 1, 2021