DOI:

10.37988/1811-153X_2020_3_36

Lipid metabolism as microecological and systemic factor in the development of periodontal disease: a review

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Authors

  • K.G. Unanyan 1, dentist
  • I.P. Balmasova 2, 3, PhD in Medical Sciences, full professor of the Infectious diseases pathogenesis and treatment Laboratory at the Medico-dental research Institute; professor of the Medical institute Allergology and immunology Department
  • V.N. Tsarev 2, PhD in Medical Sciences, full professor of the Microbiology, virology, immunology Department, director of the Medico-dental research Institute
  • A.M. Mkrtumyan 2, PhD in Medical Sciences, full professor of the Endocrinology and diabetology Department
  • K.S. Elbekyan 4, PhD in Biological Sciences, associate professor of the General and biological chemistry Department
  • K.G. Karakov 4, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
  • M.S. Gontarenko 5, Laboratory physician
  • S.D. Arutyunov 2, PhD in Medical Sciences, full professor of the Dentistry diseases propaedeutics Department
  • 1 Dinskaya Central Regional Hospital, 353200, Krasnodar Region, Russia
  • 2 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia
  • 3 RUDN University, 117198, Moscow, Russia
  • 4 Stavropol State Medical University, 355017, Stavropol, Russia
  • 5 Infectious Diseases Clinical Hospital no. 2, 105275, Moscow, Russia

Abstract

Aim — analysis of modern ideas about the relationship between the state of lipid metabolism and periodontal diseases. Materials and methods. The study was carried out by means of an analytical review of publications of Russian and foreign scientific journals, in which the results of independent clinical and laboratory studies of this material from 2005 to 2019 were presented. Results. It has been established that the role of lipids in the composition of key bacteria, which are periodontopathogens, in the process of interaction of periodontopathogenic bacteria with periodontal tissue cells, as components of human body fluids in infectious and inflammatory periodontal diseases is in no doubt and is characterized by high pathogenetic significance. Conclusion. In general, we can conclude that the lipid metabolism of both periodontopathogenic bacteria and the macroorganism at the local and systemic level plays a significant role in the occurence and progression of periodontal diseases, and studies in this direction open up broad prospects for the development of clinical periodontology and the development of new drugs for treatment and prevention of so common pathology, which is capable of inducing systemic effects.

Key words:

lipid metabolism, periodontal diseases, periodontopathogenic bacteria, systemic effects

For Citation

[1]
Unanyan K.G., Balmasova I.P., Tsarev V.N., Mkrtumyan A.M., Elbekyan K.S., Karakov K.G., Gontarenko M.S., Arutyunov S.D. Lipid metabolism as microecological and systemic factor in the development of periodontal disease: a review. Clinical Dentistry (Russia).  2020; 3 (95): 36—43. DOI: 10.37988/1811-153X_2020_3_36

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Published on

September 15, 2020