DOI:

10.37988/1811-153X_2020_2_56

Hereditary burden of patients with chronic recurrent aphthous stomatitis of the oral mucosa

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Authors

  • O.E. Bekjanova 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
  • D.M. Alimova 1, PhD in Medical sciences, associate professor of the Therapeutic dentistry department
  • V.R. Qayumova 1, assistant at the Therapeutic dentistry Department
  • 1 Tashkent State Dental Institute, 100047, Tashkent, Uzbekistan

Abstract

Analysis of the epidemiological aspects of chronic recurrent aphthous stomatitis (CRAS) indicates a possible role of hereditary factors in the occurrence diseases. In the examples described, the incidence of familial diseases varies ranging from 12 to 80%. Children, both parents of which suffer from this pathology, are 20% more likely to get sick compared to others. No doubt that family the accumulation of CRAS is due to the interaction of hereditary and external causes affecting each member of the family. Materials and methods. Studied member Information family and disease: the time of the manifestation, the presence of a burdened family history, concomitant comorbid diseases, the nature of the course, data on the treatment. Results. Of the 142 patients with CRAS, 100 (70%) had a fibrinous form of the disease, and in 43 (30%) — scarring form. A burdened history of CRAS was detected in 40 (43%) patients with a scarring form, and in 54 (57%) with fibrinous form, which indicates significant the influence of hereditary burden on the development of severe forms of CRAS (χ²=18.631; p<0.001). The presence of relatives with CRAS increases the risk of developing severe forms of the disease more than 15 times. Conclusion. Based on the results of applying descriptive statistics methods it can be concluded that the high-risk group (OR=11.099) of the development of CRAS include patients with relatives of the first or second degrees of kinship, also suffering from CRAS. Clinicians should be closely monitored by patients with two sick parents (OR=6.552), as well as brothers (OR=6.552) or sisters (OR=6.396). An increased risk of developing severe scarring forms of the disease is patients whose first or second line of relatives are also affected by CRAS.

Key words:

recurrent aphthous stomatitis, hereditary factors, siblings, probands, hereditary burden

For Citation

[1]
Bekjanova O.E., Alimova D.M., Qayumova V.R. Hereditary burden of patients with chronic recurrent aphthous stomatitis of the oral mucosa. Clinical Dentistry (Russia).  2020; 2 (94): 56—60. DOI: 10.37988/1811-153X_2020_2_56

References

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Published on

July 25, 2020