DOI:

10.37988/1811-153X_2018_4_38

Clinical and immunological approach to differential diagnostics and surgical treatment of primary chronic osteomyelitis of the lower jaw

Downloads

Authors

  • I.P. Balmasova 1, PhD in Medical Sciences, full professor of the Infectious diseases pathogenesis and treatment Laboratory at the Medico-dental research Institute
  • S.A. Trofimov 1, postgraduate at the Maxillofacial and plastic surgery Department
  • A.Ju. Drobyshev 1, PhD in Medical Sciences, full professor of the Maxillofacial and plastic surgery Department
  • V.V. Shulakov 1, PhD in Medical Sciences, professor of the Maxillofacial and plastic surgery Department
  • V.N. Tsariov 1, PhD in Medical Sciences, full professor of the Microbiology, virology, immunology Department, director of the Medico-dental research Institute
  • E.V. Ippolitov 1, PhD in Medical Sciences, professor of the Microbiology, virology, immunology Department
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

One of the topical issues in the study of osteomyelitis of the jaws is a special form of the disease with atypical passage, denoted as a primary chronic osteomyelitis, which lacks the acute phase of the disease, and productive processes prevail over destructive. The aim of the study was justification for differential diagnostic value of clinical-radiological and immunological signs of primary and secondary chronic osteomielitov jaws, including determining the effectiveness of surgical treatment. We observed 14 patients with primary chronic osteomyelitis of the low jaws. Comparison group was provided with 28 patients with secondary chronic osteomyelitis of the same localization. The study was carried out using computed tomography and clinical analysis, immunological signs were determined as different phenotypes of blood lymphocytes by flow cytometry method before and after surgical interference. It was established that there is no adjusting effect of surgical treatment on immunologic feaches of the blood of patients with primary chronic osteomyelitis of the jaw, in contrast to the positive impact of early intervention on immune status of the patients with secondary chronic osteomyelitis.

Key words:

osteomyelitis of the jaws, primary chronic osteomyelitis, differential diagnostic value, immunological signs, effectiveness of surgical treatment

For Citation

[1]
Balmasova I.P., Trofimov S.A., Drobyshev A.Ju., Shulakov V.V., Tsariov V.N., Ippolitov E.V. Clinical and immunological approach to differential diagnostics and surgical treatment of primary chronic osteomyelitis of the lower jaw. Clinical Dentistry (Russia).  2018; 4 (88): 38—43. DOI: 10.37988/1811-153X_2018_4_38

References

  1. Артемова А.В., Дикусар А.А., Щекина Л.А. Частота встречаемости остеомиелитов в практике челюстно-лицевого хирурга. - Bulletin of Medical Internet Conferences. - 2013; 3 (11): 1212.
  2. Баранник Н.Г., Варжапетян С.Д. Состояние цитокинового статуса больных вялотекущим острым одонтогенным остеомиелитом челюстей. - Science Rise. - 2015; 1(3): 25-8.
  3. Григоровский В.В. Аспекты патоморфологии и номенклатуры в современной классификации неспецифических остеомиелитов. - Ортопедия, травматология и протезирование. - 2013; (3): 77-87.
  4. Москалев А.В., Фалсафи А.Р.М. и др. Характеристика отдельных показателей врожденного и адаптивного иммунитета у больных одонтогенным остеомиелитом челюстей. - Вестник Российской военно-медицинской академии. - 2014; 4 (48): 143-7.
  5. Царев В.Н., Дробышев А.Ю., Трофимов С.А., Ипполитов Е.В., Николаева Е.Н. Взаимосвязь клинического течения хронического остеомиелита нижней челюсти и экспрессии рецепторных молекул клеточной активации. - Эндодонтия today. - 2017; 2: 41-7.
  6. Эль-Аммури Х.Х., Гаврилов В.А. Современные представления о хроническом одонтогенном остеомиелите нижней челюсти. - Загальна патологiя та патологiчна фiзiологiя. - 2013; 8 (3): 32-43.
  7. Asgary S., Eghbal M.J., Ehsani S., Eslami B. An unusual finding of proliferative periostitis in a child: a case report. - Int J Stom Res. - 2012; 1 (1): 1-5.
  8. Baltensperger M., Grätz K., Bruder E., Lebeda R., Makek M., Eyrich G. Is primary chronic osteomyelitis a uniform disease? Proposal of a classification based on a retrospective analysis of patients treated in the past 30 years. - J Craniomaxillofac Surg. - 2004; 32 (1): 43-50.
  9. Berglund C., Ekströmer K., Abtahi J. Primary chronic osteomyelitis of the jaws in children: an update on pathophysiology, radiological findings, treatment strategies, and prospective analysis of two cases. - Case Rep Dent. - 2015; 2015: 152717.DOI: https://dx.doi.org/10.1155/2015/152717
  10. De Andrade Freitas Oliveira L.S. et al. Computed tomography findings of periostitis ossificans. - Braz J Oral Sci. - 2010; 9 (1): 59-62.
  11. De Moraes F.B. et al. Garré`s sclerosing osteomyelitis: case report. - Rev Bras Ortop. - 2014; 49 (4): 401-4.
  12. Schwartz A.J., Jones N.F., Seeger L.L., Nelson S.D., Eckardt J.J. Chronic sclerosing osteomyelitis treated with wide resection and vascularized fibular autograft: a case report. - Am J Orthop. - 2010; 39 (3): 28-32.
  13. Singh S., Graham M.E. et al. Chronic sclerosing osteomyelitis of the mandible treated with hemimandibulectomy and fibular free flap reconstruction. - Plast Reconstr Surg Glob Open. - 2015; 3 (12): e580.
  14. Theologie-Lygidakis N., Schoinohoriti O., Iatrou I. Surgical management of primary chronic osteomyelitis of the jaws in children: a prospective analysis of five cases and review of the literature. - Oral Maxillofac Surg. - 2011; 15 (1): 41-50.

Downloads

Published on

December 1, 2018