DOI:

10.37988/1811-153X_2018_3_34

Aspects of the pathogenesis of vesicular lesions of the oral mucosa

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Authors

  • O.F. Rabinovich 1, PhD in Medical Sciences, head of the Oral mucosa diseases Department
  • I.M. Rabinovich 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
  • I.I. Babichenko 1, PhD in Medical Sciences, full professor of the General pathology Department
  • E.S. Abramova 1, PhD in Medical Sciences, senior researcher at the Oral mucosa diseases Division
  • 1 Central Research Institute of Dental and Maxillofacial Surgery, 119021, Moscow, Russia

Abstract

The possibility of using immunohistochemical study and the method of tissue PCR in the complex diagnosis of vesicular lesions of the oral mucosa has been studied. A total clinical and laboratory examination included 57 patients, including: patients with pemphigoid bullosa (32), pemphigus vulgaris (25). Results of immunohistochemical study indicate cellular mechanisms of epithelial damage, in which IgG, C3d fragments of the complement take part, receptors for cytokine-2, as well as antibodies against E-cadherin protein. Identification of microorganisms in pathologically altered tissues by the method of PCR should be regarded as one of the triggers of the antigenic factor in the vesicular lesions of the oral mucosa. The obtained data convincingly prove the necessity of application of these methods in complex diagnostics of vesicular lesions of the oral mucosa.

Key words:

pemphigus vulgaris, pemphigoid bullosa, clinic, histology, immunohistochemical research, tissue PCR-diagnostics

For Citation

[1]
Rabinovich O.F., Rabinovich I.M., Babichenko I.I., Abramova E.S. Aspects of the pathogenesis of vesicular lesions of the oral mucosa. Clinical Dentistry (Russia).  2018; 3 (87): 34—38. DOI: 10.37988/1811-153X_2018_3_34

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Published on

September 1, 2018