Effect of two chlorhexidine oral rinses on mucous plaque accumulation, gingivitis and dental discoloration. Randomized blind placebo-controlled study

Authors

  • K. Lorenz 1, медицинский факультет, отделение консервативной стоматологии
  • G. Brun 1, медицинский факультет, отделение консервативной стоматологии
  • S. Heumann 2, отделение статистики
  • L. Netushil 1, медицинский факультет, отделение консервативной стоматологии
  • M. Brecks , Частная практика, Брюссель, Бельгия
  • T. Gofman , Частная практика, Брюссель, Бельгия
  • 1 Дрезденский технический университет, Германия
  • 2 Мюнхенский университет, Германия

Abstract

There was no difference between chlorhexidine rinse and rinse with positive control found. 21st day of study shows statistically significant decrease of gingival inflammation and dentobacterial plaque accumulation in comparison with the placebo. There was no negative effect found except for dental discoloration and taste impression change. Two chlorhexidine rinses managed to prevent recurrent dentobacterial plaque accumulation and gingival inflammation. Neither absence of alcohol in chlorhexidine solution nor sodium fluoride addition weakens clinical effects of chlorhexidine in relation to the examined clinical factors.

Key words:

randomized blind placebo-controlled study, gingivitis

For Citation

[1]
Lorenz K., Brun G., Heumann S., Netushil L., Brecks M., Gofman T. Effect of two chlorhexidine oral rinses on mucous plaque accumulation, gingivitis and dental discoloration. Randomized blind placebo-controlled study. Clinical Dentistry (Russia).  2015; 4 (76): 74—81

References

  1. Addy M. The use of antiseptics in periodontal therapy. In: Clinical Periodontology and Implant Dentistry. Copenhagen: Blackwell Munksgaard, 2003. - pp. 464-493.
  2. Addy M., Moran J.M. Clinical indications for the use of chemical adjuncts to plaque control: hlorhexidine formulations. - Periodontology 2000. - 1997; 15: 52-4.
  3. Addy M., Wade W. An approach to efficacy screening of mouthrinses: studies on a group of French products. (I). Staining and antimicrobial properties in vitro. - Journal of Clinical Periodontology. - 1995; 22: 718-22.
  4. Addy M., Sharif N., Moran J. A nonstaining chlorhexidine mouthwash? Probably not: a study in vitro. - International Journal of Dental Hygiene. - 2005; 3: 59-63.
  5. Ainamo J., Bay I. Problems and proposals for recording gingivitis and plaque. - International Dental Journal. - 1975; 25: 229-35.
  6. Arweiler N.B., Netuschil L., Reich E. Alcohol-free mouthrinse solutions to reduce supra-gingival plaque regrowth and vitality. A controlled clinical study. - Journal of Clinical Periodontology. - 2001; 28: 168-74.
  7. Baehni P.C., Takeuchi Y. Anti-plaque agents in the prevention of biofilmassociated oraldiseases. - Oral Diseases. - 2003; 9 (suppl. I): 23-9.
  8. Bowden G.H. Mutans streptococci caries and chlorhexidine. - Journal of the Canadian Dental Association. - 1996; 62: 700-7.
  9. Brecx M., Netuschil L., Reichert B., Schreil G. Efficacy of Listerine, meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. - Journal of Clinical Periodontology. - 1990; 17: 292-7.
  10. Brecx M., MacDonald L.L., Legary K., Cheang M., Forgay M.G.E. Long-term effects of meridol and chlorhexidine mouthrinses on plaque, gingivitis, staining, and bacterial vitality. - Journal of Dental Research. - 1993; 72: 1194-7.
  11. Brecx M., Netuschil L., Hoffmann T. How to select the right mouthrinses in periodontal prevention and therapy. Part II. Clinical use and recommendations. - International Journal of Dental Hygiene. - 2003; 1: 188-94.
  12. Dolles O.K., Gjermo P. Caries increment and gingival status during 2 years’ use of chlorhexidine-and fluoride-containing dentifrices. - Scandinavian Journal of Dental Research. - 1980; 88: 22-7.
  13. Eldridge K.R., Finnie S.F., Stephens J.A., Mauad A.M., Munoz C.A., Kettering J.D. Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent. - Journal of Prosthetic Dentistry. - 1998; 80: 685-90.
  14. Etemadzadeh H., Ainamo J., Murtomaa H. Plaque growth-inhibiting effects of an abrasive fluoride-chlorhexidine toothpaste and a fluoride toothpaste containing oxidative enzymes. - Journal of Clinical Periodontology. - 1985; 12: 607-16.
  15. Fardal O., Turnbull R.S. A review of the literature on use of chlorhexidine in dentistry. - Journal of the American Dental Association. - 1986; 112: 863-9.
  16. Giertsen E., Scheie, A.A. Effects of chlorhexidine-fluoride mouthrinses on viability, acidogenic potential, and glycolytic profile of established dental plaque. - Caries Research. - 1995; 29: 181-7.
  17. Grönroos L., Mättö J., Saarela M., Luoma A.R., Luoma H., Jousimies-Somer H., Pyhälä L., Asikainen S., Alaluusua S. Chlorhexidine susceptibilities of mutans streptococcal serotypes and ribotypes. - Antimicrobial Agents and Chemotherapy. - 1995; 39: 894-8.
  18. Gusberti F.A., Sampathkumar P., Siegrist B.E., Lang N.P. Microbiological and clinical effects of chlorhexidine digluconate and hydrogen peroxide mouthrinses on developing plaque and gingivitis. - Journal of Clinical Periodontology. - 1988; 15: 60-7.
  19. Hoffmann T., Bruhn G., Richter S., Netuschil L., Brecx M. Clinical controlled study on plaque and gingivitis reduction under long term use of low dose chlorhexidine solutions in a population exhibiting good oral hygiene. - Clinical Oral Investigations. - 2001; 5: 89-95.
  20. Jenkins S., Addy M., Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. - Clinical Preventive Dentistry. - 1989; 11:12-6.
  21. Jenkins S., Addy M., Newcombe R. The effects of a chlorhexidine toothpaste on the development of plaque, gingivitis and tooth staining. - Journal of Clinical Periodontology. - 1993; 20: 59-62.
  22. Jones C.G. Chlorhexidine: is it still the gold standard? - Periodontology 2000. - 1997; 15: 55-62.
  23. Joyston-Bechal S., Hernaman N. The effect of a mouthrinse containing chlorhexidine and fluoride on plaque and gingival bleeding. - J Clin Periodontol. - 1993; 20 (1): 49-53.
  24. Kidd E.A.M. Role of chlorhexidine in the management of dental caries. - International Dental Journal. - 1991; 41: 279-86.
  25. Lang N.P., Hase J.C., Grassi M., Hammerle C.H.F., Weigel C., Kelty E., Frutig F. Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 6 months. - Oral Diseases. - 1998; 4: 105-13.
  26. Löe H. The gingival index, the plaque index and the retention index systems. - Journal of Periodontology. - 1967; 38:610-6.
  27. Löe H., Schiott C.R. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. - Journal of Periodontal Research. - 1970; 5: 79-83.
  28. Löe H., Theilade E., Jensen S.B. Experimental gingivitis in man. - Journal of Periodontology. - 1965; 36:177-87.
  29. Mendieta C., Vallcorba N., Binney A., Addy M. Comparison of 2 chlorhexidine mouthwashes on plaque regrowth in vivo and dietary staining in vitro. - Journal of Clinical Periodontology. - 1994; 21: 296-300.
  30. Nuuja T., Meurman J.H., Murtomaa H., Kortelainen S., Metteri J. The effect of a combination of chlorhexidine diacetate, sodium fluoride and xylitol on plaque wet weight and periodontal index scores in military academy cadets refraining from mechanical tooth cleaning for 7-day experimental periods. - Journal of Clinical Periodontology. - 1992; 19: 73-6.
  31. Petersson L.G., Netuschil L., Brecx, M. Mouthrinses and dental caries. - International Dental Journal. - 2002; 52: 337-45.
  32. Quirynen M., Avontroodt P., Peeters W., Pauwels M., Coucke W., Van Steenberghe D. Effect of different chlorhexidine formulations in mouthrinses on de novo plaque formation. - Journal of Clinical Periodontology. - 2001; 28: 1127-36.
  33. Renton-Harper P., Milsom S., Wade W., Addy M., Moran J., Newcombe R.G. An approach to efficacy screening of mouthrinses: studies on a group of French products. (II). Inhibition of salivary bacteria and plaque in vivo. - Journal of Clinical Periodontology. - 1995; 22: 723-7.
  34. Richter S., Bruhn G., Netuschil N., Brecx M., Federlin-Ducani M., Hoffmann T. Klinisch kontrollierte Studie zur Wirksamkeit einer 0.05%igen Chlorhexidin-Mundspu.llo.sung. - Deutsche Zahnarztliche Zeitschrift. - 2001; 56: 193-6.
  35. Siegrist B.E., Gusberti F.A., Brecx M.C., Weber H.P., Lang N.P. Efficacy of supervised rinsing with chlorhexidine digluconate in comparison to phenolic and plant alkaloid compounds. - Journal of Periodontal Research. - 1986; 21: 60-73.
  36. Silness J., Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal conditions. - Acta Odontologica Scandinavica. - 1964; 22: 121-35.
  37. Twetman S., Petersson L.G. Efficacy of a chlorhexidine and a chlorhexidine-fluoride varnish mixture to decrease interdental levels of mutans streptococci. - Caries Research. - 1997; 31: 361-5.
  38. Van Rijkom H.M., Truin G.J., vant’t Hoff M.A. A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment. - Journal of Dental Research. - 1996; 75: 790-5.

Published on

December 1, 2015