Studying the clinical effectiveness of local application of a topical immunomodulator in the treatment of recurrent aphthous stomatitis

Abstract

The purpose of the study is to evaluate the effectiveness of local use of the topical immunomodulator «Superlymph» in the treatment of recurrent aphthous stomatitis.
Materials and methods.
A study was conducted on 70 patients aged 18 to 55 years with recurrent aphthous stomatitis. The patients were divided into 2 groups depending on the methods of local treatment. The main group included 40 patients who used the topical immunomodulator «Superlimf» as a local treatment. The control group was represented by 30 patients who used epithelializing agents and medicines affecting the microbiota (antibacterial agents, bacteriophages, local probiotics) for local treatment. The microbial and viral composition of oral scrapings was studied before and after treatment. The dynamics of changes in clinical manifestations were recorded by assessing the degree of pain, the timing of aphthae reduction in size and the timing of their healing.
Results.
Dysbiosis of varying degrees was detected in 80% of patients. Increased growth rates of Streptococcus spp., Staphylococcus spp., Enterobacteriaceae spp., Candida albicans, Neisseria spp. were noted. Herpes viruses were also detected with high frequency. For example, herpes simplex virus type 1 and type 2 were detected in 75% of cases in the main group before treatment, and in 70% of cases in the control group. After local treatment, the results of the study improved in both groups. In the main group, the number of patients with changes in the composition of the microbiota decreased to 30%, and in the control group to 40%. Patients in whom herpes simplex virus type 1 and type 2 was determined after treatment accounted for only 28% in the main group and 40% in the control group. The dynamics of the disease course was also positive in both groups. The average healing time for aphthae in the main group decreased to 7 days, and in the control group to 10 days.
Conclusion.
Local use of the topical immunomodulator» Superlymph» in the treatment of patients with recurrent aphthous stomatitis showed better results along with traditional drugs for local symptomatic treatment.
Conclusion.
Local use of the topical immunomodulator Superlymph in the treatment of patients with recurrent aphthous stomatitis showed better results along with traditional drugs for local symptomatic treatment.