DOI:

10.37988/1811-153X_2024_2_11

Effect of vitamin D in the treatment of chronic apical periodontitis in patients with osteopenia

Downloads

Authors

  • T.V. Alkhazurova 1, assistant at the Therapeutic dentistry Department
    ORCID ID: 0009-0004-8681-2794
  • I.M. Makeeva 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department, director of the Institute of Dentistry
    ORCID ID: 0000-0002-7878-0452
  • L.L. Borozdkin 1, PhD in Medical Sciences, associate professor of the Maxillofacial surgery Department
    ORCID ID: 0000-0002-6403-2621
  • E.S. Storozhenko 1, 5th year student
    ORCID ID: 0009-0000-5834-5982
  • N.N. Krapukhina 1, 5th year student
    ORCID ID: 0009-0007-4267-7035
  • A.E. Dyakova 1, 5th year student
    ORCID ID: 0009-0005-8207-0006
  • I.V. Ivanova 1, clinical resident at the Maxillofacial surgery Department
    ORCID ID: 0000-0002-8244-4136
  • Ya.V. Samokhlib 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0001-5330-5092
  • A.Yu. Turkina 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0003-2852-0051
  • 1 Sechenov University, 119991, Moscow, Russia

Abstract

The aim of the study was to conduct a clinical evaluation of the efficacy of vitamin D administration in the treatment of chronic apical periodontitis in patients with osteopenia.
Materials and methods.
Treatment of chronic apical periodontitis in 128 patients was carried out; vitamin 25(OH)D concentration in blood serum was measured, densitometry to determine bone tissue density, and the volume of destruction foci was measured at the whole stage of treatment. We studied the rate of bone tissue regeneration during the treatment of chronic apical periodontitis in patients with and without osteopenia.
Results.
Of 128 patients, 48 had osteopenia exposed. Patients with osteopenia do not have complete bone remodeling after 18 months, in contrast to the group of patients without osteopenia. Periapical tissue remodeling in patients with osteopenia takes 12 months longer than in patients without osteopenia. When comparing the period of bone tissue remodeling in patients with osteopenia with vitamin D deficiency and its correction and in patients with osteopenia, low vitamin 25(OH)D level and without its correction in the time of treatment, a difference of 20 months (p<0.001) was determined.
Conclusion.
The efficacy of treatment of chronic apical periodontitis is significantly influenced by the presence of systemic osteopenia, deficiency of vitamin D level and the presence of its correction. In the treatment of persistent chronic apical periodontitis it is advisable to carry out such additional methods of examination as determination of 25(OH)D content in blood serum and densitometry, if indicated, correction of indices should be carried out by an endocrinologist.

Key words:

vitamin D, osteopenia, endodontic treatment, chronic apical periodontitis

For Citation

[1]
Alkhazurova T.V., Makeeva I.M., Borozdkin L.L., Storozhenko E.S., Krapukhina N.N., Dyakova A.E., Ivanova I.V., Samokhlib Ya.V., Turkina A.Yu. Effect of vitamin D in the treatment of chronic apical periodontitis in patients with osteopenia. Clinical Dentistry (Russia).  2024; 27 (2): 11—15. DOI: 10.37988/1811-153X_2024_2_11

References

  1. Kulikov A.S., Zhad‘ko S.I., Kriventsov M.A. Current views on pathogenetic factors of periodontitis development and potential effects of ligand-associated activation of vitamin D receptors: literature review. Clinical Dentistry (Russia). 2023; 3: 20—29 (In Russian). eLIBRARY ID: 54509004
  2. Silva I.C.J., Lazaretti-Castro M. Vitamin D metabolism and extraskeletal outcomes: an update. Arch Endocrinol Metab. 2022; 66 (5): 748—755. PMID: 36382764
  3. Holick M.F. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017; 18 (2): 153—165. PMID: 28516265
  4. Rudenka A.V., Rudenka E.V., Samokhovec V.Yu., Kobets K.V., Marozik P.M. Association of vitamin D receptor gene polymorphism with a bone mineral density level in postmenopausal women. Proceedings of the National Academy of Sciences of Belarus. Medical Series. 2019; 2: 192—201 (In Russian). eLIBRARY ID: 39387633
  5. Cianferotti L. Osteomalacia is not a single disease. Int J Mol Sci. 2022; 23 (23): 14896. PMID: 36499221
  6. Napartivaumnuay N., Gramlich L. The prevalence of vitamin D Insufficiency and deficiency and their relationship with bone mineral density and fracture risk in adults receiving long-term home parenteral nutrition. Nutrients. 2017; 9 (5): 481. PMID: 28489034
  7. Ringe J.D. Plain vitamin D or active vitamin D in the treatment of osteoporosis: where do we stand today? — Arch Osteoporos. 2020; 15 (1): 182. PMID: 33188611
  8. Patil V.S., Mali R.S., Moghe A.S. Evaluation and comparison of vitamin D receptors in periodontal ligament tissue of vitamin D-deficient chronic periodontitis patients before and after supplementation of Vitamin D3. J Indian Soc Periodontol. 2019; 23 (2): 100—105. PMID: 30983779
  9. Wu M., Cai Y.L., Yang Y., Hu H.M., Yao Y., Yang J., Deng J.J., Wan L. Vitamin D ameliorates insulin resistance-induced osteopenia by inactivating the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome. Heliyon. 2023; 9 (2): e13215. PMID: 36816288
  10. Zihni Korkmaz M., Yemenoğlu H., Günaçar D.N., Ustaoğlu G., Ateş Yildirim E. The effects of vitamin D deficiency on mandibular bone structure: a retrospective radiological study. Oral Radiol. 2023; 39 (1): 67—74. PMID: 35277812
  11. Ivanova I.V., Ivanov S.Yu., Gusarov A.M., Muraev A.A. Influence of vitamin D on the reconstitutional processes of bone tissue: a review. Clinical Dentistry (Russia). 2023; 2: 98—104 (In Russian). eLIBRARY ID: 54167532
  12. Katz J., Rotstein I. Prevalence of periapical lesions in patients with osteoporosis. J Endod. 2021; 47 (2): 234—238. PMID: 33130060

Downloads

Received

November 19, 2023

Accepted

May 26, 2024

Published on

June 28, 2024