DOI:

10.37988/1811-153X_2024_2_11

Effect of vitamin D in the treatment of chronic apical periodontitis in patients with osteopenia

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Authors

  • T.V. Alkhazurova 1, assistant at the Therapeutic dentistry Department
    ORCID: 0009-0004-8681-2794
  • I.M. Makeeva 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department, director of the Institute of Dentistry
    ORCID: 0000-0002-7878-0452
  • L.L. Borozdkin 1, PhD in Medical Sciences, associate professor of the Maxillofacial surgery Department
    ORCID: 0000-0002-6403-2621
  • E.S. Storozhenko 1, 5th year student
    ORCID: 0009-0000-5834-5982
  • N.N. Krapukhina 1, 5th year student
    ORCID: 0009-0007-4267-7035
  • A.E. Dyakova 1, 5th year student
    ORCID: 0009-0005-8207-0006
  • I.V. Ivanova 1, clinical resident at the Maxillofacial surgery Department
    ORCID: 0000-0002-8244-4136
  • Ya.V. Samokhlib 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0001-5330-5092
  • A.Yu. Turkina 1, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0003-2852-0051
  • 1 Sechenov University, 119991, Moscow, Russia

Abstract

The aim of the study was to conduct a clinical evaluation of the efficacy of vitamin D administration in the treatment of chronic apical periodontitis in patients with osteopenia.
Materials and methods.
Treatment of chronic apical periodontitis in 128 patients was carried out; vitamin 25(OH)D concentration in blood serum was measured, densitometry to determine bone tissue density, and the volume of destruction foci was measured at the whole stage of treatment. We studied the rate of bone tissue regeneration during the treatment of chronic apical periodontitis in patients with and without osteopenia.
Results.
Of 128 patients, 48 had osteopenia exposed. Patients with osteopenia do not have complete bone remodeling after 18 months, in contrast to the group of patients without osteopenia. Periapical tissue remodeling in patients with osteopenia takes 12 months longer than in patients without osteopenia. When comparing the period of bone tissue remodeling in patients with osteopenia with vitamin D deficiency and its correction and in patients with osteopenia, low vitamin 25(OH)D level and without its correction in the time of treatment, a difference of 20 months (p<0.001) was determined.
Conclusion.
The efficacy of treatment of chronic apical periodontitis is significantly influenced by the presence of systemic osteopenia, deficiency of vitamin D level and the presence of its correction. In the treatment of persistent chronic apical periodontitis it is advisable to carry out such additional methods of examination as determination of 25(OH)D content in blood serum and densitometry, if indicated, correction of indices should be carried out by an endocrinologist.

Key words:

vitamin D, osteopenia, endodontic treatment, chronic apical periodontitis

For Citation

[1]
Alkhazurova T.V., Makeeva I.M., Borozdkin L.L., Storozhenko E.S., Krapukhina N.N., Dyakova A.E., Ivanova I.V., Samokhlib Ya.V., Turkina A.Yu. Effect of vitamin D in the treatment of chronic apical periodontitis in patients with osteopenia. Clinical Dentistry (Russia).  2024; 27 (2): 11—15. DOI: 10.37988/1811-153X_2024_2_11

References

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Received

November 19, 2023

Accepted

May 26, 2024

Published on

June 28, 2024