DOI:

10.37988/1811-153X_2023_4_80

Experimental substantiation of the effectiveness of the use of a new phytocomposition in the prevention and dental examination of cancer patients with complications of chemotherapy and radiation therapy

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Authors

  • A.V. Vazhenin 1, Academician of the Russian Academy of Sciences, PhD in Medical Sciences, full professor of the Oncology, radiation diagnostics and radiation therapy Department
    ORCID: 0000-0002-7912-9039
  • D.G. Kiparisova 1, PhD in Medical Sciences, assistant professor of the Prosthetic dentistry Department
    ORCID: 0000-0003-1805-3365
  • Yu.S. Kiparisov 1, postgraduate at the Prosthodontics and orthodontics Department
    ORCID: 0000-0001-6046-3777
  • M.S. Podporin 2, PhD in Medical Sciences, researcher at the Molecular biology research Laboratory of the Medico-dental research Institute
    ORCID: 0000-0001-6785-0016
  • A.G. Ponomareva 2, PhD in Medical Sciences, professor of the Microbiology, virology, immunology Department
    ORCID: 0000-0002-2685-7235
  • V.N. Tsarev 2, PhD in Medical Sciences, director of the Medico-dental research Institute
    ORCID: 0000-0002-3311-0367
  • S.D. Arutyunov 2, PhD in Medical Sciences, full professor of the Digital dentistry Department
    ORCID: 0000-0001-6512-8724
  • 1 South Ural State Medical University, 454092, Chelyabinsk, Russia
  • 2 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

The article discusses the possibility of applying phytopsychological collection in the context of therapeutic and prophylactic measures in the oral cavity after the surgical, chemical and orthopedic stages of treatment in the maxillofacial diseases. The purpose of the study is the experimental substantiation of antimicrobial efficiency, proposed phytocompaction in comparison with the known consortium groups of priority microbial agents of purulent inflammation in the correction of microbiota in patients of oncological genesis.
Materials and methods.
The experiment was based on automatic programmable cultivation, with real-time evaluation of microbial populations. In the course of the experiment, the following strains were assessed under the periodic cultivation system: S. sanguis, F. nucleatum, C. albicans. The interpretation of the results was carried out by estimating the optical density indicator taking into account the statistical regression index of the bacterial population growth curve.
Results.
The Mukosept Phyto-Mass study promotes a longer delay in the development of microbial cells in the initial stages of population cultivation and reduces the amplitude of the population growth curve, which helps to change the trend of cell development in comparison with the control sample and prototype.
Conclusion.
Phytohormone-based rinse rinses prevent the effects of chemolysis therapy along with a pronounced antimicrobial and cleansing effect of phytohormone helps improve oral hygiene and may have a phytotherapeutic effect on the whole body.

Key words:

phytochemistry, maxillofacial cancer, microbiological monitoring, antimicrobial activity

For Citation

[1]
Vazhenin A.V., Kiparisova D.G., Kiparisov Yu.S., Podporin M.S., Ponomareva A.G., Tsarev V.N., Arutyunov S.D. Experimental substantiation of the effectiveness of the use of a new phytocomposition in the prevention and dental examination of cancer patients with complications of chemotherapy and radiation therapy. Clinical Dentistry (Russia).  2024; 26 (4): 80—90. DOI: 10.37988/1811-153X_2023_4_80

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Received

October 5, 2023

Accepted

November 29, 2023

Published on

January 16, 2024