DOI:

10.37988/1811-153X_2023_4_71

Filifactor alocis and its associations with anaerobic bacteria in patients with periodontitis and cardiovascular diseases

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Authors

  • E.N. Nikolaeva 1, PhD in Medical Sciences, full professor of the Molecular biology research Laboratory, principal scientist
    ORCID: 0000-0002-7854-3262
  • O.O. Yanuchevich 1, Academician of the Russian Academy of Sciences, PhD in Medical Sciences, full professor of the Periodontology Department
    ORCID: 0000-0003-0059-4980
  • T.V. Tsareva 1, PhD in Medical Sciences, associate professor of the Microbiology, virology, immunology Department
    ORCID: 0000-0001-9571-0520
  • M.S. Podporin 1, PhD in Medical Sciences, researcher at the Molecular biology research Laboratory of the Medico-dental research Institute
    ORCID: 0000-0001-6785-0016
  • V.N. Tsarev 1, PhD in Medical Sciences, full professor of the Microbiology, virology, immunology Department
    ORCID: 0000-0002-3311-0367
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

Microbial damage to periodontal tissues is closely associated with a number of systemic diseases and, possibly, plays an important role in the occurrence of comorbid pathology. The aim of the work is to identify the pathogen Filifactor alocis as a new diagnostic indicator of periodontal disease in patients with chronic periodontitis with coronary heart disease (CHD).
Materials and methods.
We examined 180 patients with chronic periodontitis (CP) and cardiovascular diseases (CVD), including: acute myocardial infarction (AMI), angina pectoris I—II FC classes (AP), coronary artery disease with postinfarction cardiosclerosis (CAD) and indications for myocardial revascularization. Control group — 60 patients with chronic periodontitis of moderate severity without CVD. Dental and cardiological status, endothelial dysfunction, DNA composition of the main types of periodontal pathogens, including a new marker of periodontitis F. alocis in the subgingival biofilm of patients, and a biochemical blood test were assessed.
Results.
Statistically significant relationship found between the colonization of the subgingival biofilm by periodontal pathogens F. alocis and P. gingivalis with the presence of CVD. In patients with coronary artery disease, the frequency of detection of F. alocis and P. gingivalis, including the joint, is higher than in people without CVD. The risk ratio for the presence of F. alocis and P. gingivalis in patients with AMI was 2.76 (95% CI 1.24—6.15; p<0.05); CAD patients — 2.25 (95% CI 1.00—5.03; p<0.05); angina pectoris — 1.95 (95% CI 0.86—4.38; p>0.05). Relationships of F. alocis and P. gingivalis with clinical manifestations of acute and chronic cardiovascular diseases were revealed, which may indicate their role as key pathogens of inflammatory periodontal diseases and auxiliary pathogens in CVD.
Conclusion.
The results of a prospective study confirm the important role of key periodontal pathogenic species in the pathology under consideration and indicate the practical need to identify F. alocis and P. gingivalis in patients with CP, including those with comorbid CVD.

Key words:

periodontal pathogens, subgingival biofilm, DNA, cardiovascular diseases

For Citation

[1]
Nikolaeva E.N., Yanuchevich O.O., Tsareva T.V., Podporin M.S., Tsarev V.N. Filifactor alocis and its associations with anaerobic bacteria in patients with periodontitis and cardiovascular diseases. Clinical Dentistry (Russia).  2024; 26 (4): 71—79. DOI: 10.37988/1811-153X_2023_4_71

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Received

August 27, 2023

Accepted

November 21, 2023

Published on

January 16, 2024