DOI:

10.37988/1811-153X_2023_3_60

Issues of salivary glands neoplasms diagnosis

Downloads

Authors

  • E.V. Kuz’mina 1, PhD in Medical Sciences, associate professor and head of the Oral and maxillofacial surgery Department
  • M.V. Sotnikova 1, PhD in Medical Sciences, associate professor of the Oral and maxillofacial surgery Department
  • V.N. Borovoj 1, 2, PhD in Medical Sciences, associate professor of the Oral and maxillofacial surgery Department; head of the Maxillofacial surgery ward
  • D.A. Nakonechnyi 1, PhD in Medical Sciences, assistant professor of the the Oral and maxillofacial surgery Department
  • 1 Smolensk State Medical University, 214019, Smolensk, Russia
  • 2 Smolensk Regional Clinical Hospital, 214018, Smolensk, Russia

Abstract

Diagnosis of salivary glands neoplasms is a complex issue. The number of patients is steadily growing. Salivary glands neoplasms are very diverse and don’t have a specific clinical course, therefore, diagnostic errors are 7—46%. The aim was improving the diagnosis of salivary glands neoplasms.
Materials and methods.
We conducted a retrospective analysis of 81 patients’ medical histories with a preliminary diagnosis “salivary gland neoplasm”. Based on the pathohistological study an analysis of the accuracy of clinical, ultrasound and cytological investigation was carried out.
Results.
Diagnosis of salivary glands neoplasm was confirmed pathohistologically in 88%. In 89% process was localized in the parotid gland, in 8% — in submandibular and in 3% — in sublingual. Tumours’ recurrences were detected in 6%. Ultrasound investigation revealed the presence of neoplasms in 76%. The accuracy of cytological examination in patients with pleomorphic adenoma was 63%. In patients with adenolymphoma — 40%. The cytological method wasn’t informative in patients with rare benign and malignant tumors. Only the pathohistological study identified them. Benign tumors were the most common — 87%. 63% were revealed pleomorphic adenomas. Malignant tumors were observed in 7%, cysts — in 6%.
Conclusion.
The frequency of diagnostic errors in patients with salivary glands neoplasms remains high. Clinical examination of that patients should be supplemented with the results of ultrasound and cytological investigation, since none of the methods makes it possible to precisely diagnose. Only the comprehensive analysis can reduce the number of diagnostic errors. In doubtful cases it is recommended to conduct the pathohistological study.

Key words:

neoplasm, tumor, cyst, the salivary gland, diagnosis

For Citation

[1]
Kuz’mina E.V., Sotnikova M.V., Borovoj V.N., Nakonechnyi D.A. Issues of salivary glands neoplasms diagnosis. Clinical Dentistry (Russia).  2023; 26 (3): 60—69. DOI: 10.37988/1811-153X_2023_3_60

References

  1. Shumkova E.N., Balapanova A.K., Alsheriyeva U.A., Iskakov A.Z. Clinical and morphological aspects of salivary gland tumors. Herald of Science and Education. 2020; 14—1 (92): 74—76 (In Russian). eLIBRARY ID: 43144570
  2. Bychkov D.V., Batoroev J.K., Vjazmin A.J. Problems of preoperative diagnostics of tumors of salivary glands. Siberian medical journal (Irkutsk). 2011; 6: 33—36 (In Russian). eLIBRARY ID: 17053506
  3. Zhumabaev A.R., Mamajakyp uulu J. Morbidity and molecular aspects of diagnostics of salivary gland tumors (a brief literature review). Eurasian Scientific Association. 2021; 4—2 (74): 120—124 (In Russian). eLIBRARY ID: 45754328
  4. Rutskij N.F., Zabelin A.S., Borovoj V.N., Samusenko E.G. Tumours of the salivary glands. Bulletin of the Smolensk State Medical Academy. 2010; 2: 114—115 (In Russian). eLIBRARY ID: 17051352
  5. Paches A.I., Tabolinskaya T.D. Tumors of the salivary glands. Moscow: Practical medicine, 2009. 470 p. (In Russian).
  6. Nurov R.R., Abdurahimov O.N., Yusupova D.B. Good-quality and malignant new growth of salivary glands. International Scientific Review. 2017; 8 (39): 70—73 (In Russian). eLIBRARY ID: 29914660
  7. Ageev I.S., Grishaev A.A., Panyushov S.P., Tyumin V.B. Analysis of patients with neoplasms of the parotid salivary glands (based on the materials of the Penza region). University Proceedings. Volga region. Medical sciences. 2007; 4 (4): 51—54 (In Russian). eLIBRARY ID: 13219144
  8. Bychkov D.V., Alyoshkin I.G., Batoroyev Yu.K., Kazimirsky V.A., Kekidze S.Yu., Khabudayeva I.A., Rysina I.A. Problems in clinical diagnostics of salivary tumors. Siberian medical journal (Irkutsk). 2016; 3: 58—61 (In Russian). eLIBRARY ID: 27335205
  9. Bychkov D.V., Vjazmin A.J., Batoroyev Yu.K., Baifa A.A. Errors of differential diagnostics of oncomas of the salivary glands. Bulletin of Eastern-Siberian Scientific Center of Siberian Branch of Russian Academy of Medical Sciences. 2011; 4—2 (80): 22—24 (In Russian). eLIBRARY ID: 17270184
  10. Speight P.M., Barrett A.W. Salivary gland tumours: diagnostic challenges and an update on the latest WHO classification. Diagnostic Histopathology. 2020, 26 (4): 147—158. DOI: 10.1016/j.mpdhp.2020.01.001
  11. Nurov R.R., Mamatova M.S., Kurbankulov U.M. Epidemiology tumours of salivary glands (review). European Research. 2017; 8 (31): 58—60 (In Russian). eLIBRARY ID: 29952348
  12. Dregalkina A.A., Kokovina T.A. Nalysis of relapse benign tumors of the salivary glands. Actual Problems in Dentistry. 2014; 3: 26—29 (In Russian). eLIBRARY ID: 21774948
  13. Shestopalova O., Bubnova E., Lukina O., Yakovenko A. Differential diagnosis of salivary gland tumors: a new approach. Vrach. 2019; 5: 85—87 (In Russian). eLIBRARY ID: 37625734
  14. Valstar M.H., de Ridder M., van den Broek E.C., Stuiver M.M., van Dijk B.A.C., van Velthuysen M.L.F., Balm A.J.M., Smeele L.E. Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncol. 2017; 66: 93—99. PMID: 28249655
  15. Smyslenova M.V., Tarasenko S.V., Shipkova T.P., Rudnev A.I., Faskhutdinov D.K. Capabilities of ultrasound study in the differential diagnosis of neoplasms of the major salivary glands. Journal of Radiology and Nuclear Medicine. 2012; 3: 008—011 (In Russian). eLIBRARY ID: 20786494
  16. Nikolaeva N.V., Barashkina V.S., Sokolova M.V., Nizovtsova L.A. Ultrasound diagnostics of diseases of the parotid salivary glands in the practical work of a polyclinic doctor: Pilot results. Radiology and Practice. 2022; 6 (96): 22—32 (In Russian). eLIBRARY ID: 49950823
  17. Rudack C., Jörg S., Kloska S., Stoll W., Thiede O. Neither MRI, CT nor US is superior to diagnose tumors in the salivary glands—an extended case study. Head Face Med. 2007; 3: 19. PMID: 17407595
  18. Dudareva I.V., Lastovka A.S., Kushnirov A.I. The comparison of the macro- and sonographic structure of adenolymphoma. Retrospective analysis. Health and Ecology Issues. 2016; 1 (47): 31—35 (In Russian). eLIBRARY ID: 25724841
  19. Bazarov N.I., Ikromov Z.N., Sharipov H.Y., Masaidova L.V. Cyto-histological characteristics of abundant tumours of salivary glands. Avicenna Bulletin. 2017; 2: 189—193 (In Russian). eLIBRARY ID: 32205146
  20. Osipyan E.M., Berezina A.E., Galstyan M.V., Oganesyan I.G., Vasilenko I.A., Gurevich L.E., Kekalo A.I. The importance of cytomorphological studies in the diagnosis of diseases of the salivary glands. Medical News of North Caucasus. 2011; 2: 44—48 (In Russian). eLIBRARY ID: 16448593
  21. Iyer J., Hariharan A., Cao U.M.N., Mai C.T.T., Wang A., Khayambashi P., Nguyen B.H., Safi L., Tran S.D. An overview on the histogenesis and morphogenesis of salivary gland neoplasms and evolving diagnostic approaches. Cancers (Basel). 2021; 13 (15): 3910. PMID: 34359811
  22. Jain R., Gupta R., Kudesia M., Singh S. Fine needle aspiration cytology in diagnosis of salivary gland lesions: A study with histologic comparison. Cytojournal. 2013; 10: 5. PMID: 23599724
  23. Shetty A., Geethamani V. Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation. J Oral Maxillofac Pathol. 2016; 20 (2): 224—9. PMID: 27601813
  24. Fakhry N., Antonini F., Michel J., Penicaud M., Mancini J., Lagier A., Santini L., Turner F., Chrestian M.A., Zanaret M., Dessi P., Giovanni A. Fine-needle aspiration cytology in the management of parotid masses: evaluation of 249 patients. Eur Ann Otorhinolaryngol Head Neck Dis. 2012; 129 (3): 131—5. PMID: 22626640
  25. Bychkov D.V., Batoroev Y.K., Alyoshkin I.G., Kislitsyna L.Y., Kazimirsky V.A., Rayevskaya L.Y., Nemchinova S.V., Filchenkova E.V. Proliferative activity of salivary tumor cells. Bulletin of Eastern-Siberian Scientific Center of Siberian Branch of Russian Academy of Medical Sciences. 2016; 5 (111): 68—70 (In Russian). eLIBRARY ID: 27193016
  26. Rossi E.D., Baloch Z., Pusztaszeri M., Faquin W.C. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC-sponsored system for reporting salivary gland fine-needle aspiration. J Am Soc Cytopathol. 2018; 7 (3): 111—118. PMID: 31043307
  27. Sumana S.V., Roopashree G., Bharathi M., The Milan S. for reporting salivary gland cytopathology (MSRSGC). Journal of Medical Science and Clinical Research. 2019; 7 (11): 982—988. DOI: 10.18535/jmscr/v7i11.170
  28. Jo H.J., Ahn H.J., Jung S., Yoon H.K. Diagnostic difficulties in fine needle aspiration of benign salivary glandular lesions. Korean J Pathol. 2012; 46 (6): 569—75. PMID: 23323108
  29. Peravali R.K., Bhat H.H., Upadya V.H., Agarwal A., Naag S. Salivary gland tumors: a diagnostic dilemma! J Maxillofac Oral Surg. 2015; 14 (Suppl 1): 438—42. PMID: 25848154
  30. Dudareva I.V., Erokhina O.A. Information content of the conventional methods of cytological diagnosis adenolimfom. Sovremennaya stomatologiya (Belarus). 2013; 2 (57): 93—96 (In Russian). eLIBRARY ID: 20458651
  31. Ermakova L.A., Zolotovitskaya O.S., Dobrohotova C.G., Kivatskiy A.V., Bormotov A.V., Yagudin A.S. Adenolymphoma of salivary gland. Russian News of Clinical Cytology. 2016; 1—2: 18—19 (In Russian). eLIBRARY ID: 43356187

Downloads

Received

April 26, 2023

Accepted

July 27, 2023

Published on

September 24, 2023