DOI:

10.37988/1811-153X_2023_1_12

Dental status of patients with cystic fibrosis (a review)

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Authors

  • M.A. Postnikov 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-2232-8870
  • M.S. Saburova 1, assistant at the Therapeutic dentistry Department
    ORCID: 0000-0002-2220-6320
  • O.V. Kondratenko 1, PhD in Medical science, associate professor of the General and clinical microbiology, immunology and allergology Department
    ORCID: 0000-0002-7750-9468
  • A.M. Khamadeeva 1, PhD in Medical Sciences, full professor of the Pediatric dentistry and orthodontics Department
  • S.I. Vyrmaskin 1, PhD in Medical sciences, associate professor of the Dentistry department
    ORCID: 0000-0002-7778-0864
  • O.E. Simanovskaya 1, PhD in Medical sciences, associate professor of the Therapeutic dentistry Department
    ORCID: 0000-0002-7741-272X
  • A.V. Pashkova 1, resident at the Therapeutic dentistry Department
    ORCID: 0000-0002-7605-1766
  • 1 Samara State Medical University, 443001, Samara, Russia

Abstract

Cystic fibrosis is a genetically determined disease, which is based on a violation of salt metabolism. It is most common among people of European origin. This disease is multisystem, the gastrointestinal tract, pancreas, liver, respiratory tract, salivary and sweat glands, as well as the reproductive system are affected. In the 1950—1960s cystic fibrosis was considered a fatal disease, the vast majority of patients did not live to 5 years. Currently, due to the continuous improvement of treatment and rehabilitation methods, the duration and quality of life of people with this pathology has increased significantly. However, in more than 90% of cases, the development of severe complications due to chronic insufficiency of the respiratory system is observed. A broad evidence base confirms the negative impact of chemical and metabolic disorders accompanying diseases and pathological conditions on the condition of organs and tissues of the oral cavity. Violation of water-salt metabolism, damage to the salivary glands, prolonged courses of antibiotic, hormone and enzyme therapy for cystic fibrosis are reflected in the level of dental health of these patients. Long courses of antibacterial therapy are the cause of exfoliative and angular cheilitis, candidiasis of the oral mucosa, the presence of xerostomia and hemorrhages on the oral mucosa become a manifestation of salivary gland insufficiency, a number of patients with cystic fibrosis have a combination of several signs of tongue pathology, non-carious lesions of hard dental tissues and periodontal diseases are widespread. >. Despite the proven fact of the presence of oral diseases in patients with cystic fibrosis, the issues of diagnosis, identification of risk factors for their development are not given due attention.

Key words:

cystic fibrosis, oral mucosa, gingivitis, caries, nonspecific resistance of the oral cavity

For Citation

[1]
Postnikov M.A., Saburova M.S., Kondratenko O.V., Khamadeeva A.M., Vyrmaskin S.I., Simanovskaya O.E., Pashkova A.V. Dental status of patients with cystic fibrosis (a review). Clinical Dentistry (Russia).  2023; 26 (1): 12—17. DOI: 10.37988/1811-153X_2023_1_12

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Received

September 20, 2022

Accepted

February 19, 2023

Published on

March 22, 2023