DOI:

10.37988/1811-153X_2022_4_44

Comparative evaluation of the effect of topical and systemic dosage forms on oral microbiocenosis in difficult eruption of temporary teeth

Downloads

Authors

  • V.N. Tsarev 1, PhD in Medical Sciences, full professor of the Microbiology, virology, immunology department, director of the Medico-dental research Institute
    ORCID: 0000-0002-3311-0367
  • L.P. Kiselnikova 1, PhD in Medical Sciences, full professor of the Paediatric dentistry Department
    ORCID: 0000-0003-2095-9473
  • M.S. Podporin 1, PhD in Medical Sciences, researcher at the Molecular biology research Laboratory of the Medico-dental research Institute
    ORCID: 0000-0001-6785-0016
  • F.M. Balafendieva 1, postgraduate at the Paediatric dentistry Department
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

Eruption of temporary teeth in children is accompanied by unpleasant pain sensations, development of edema, inflammation of the gums, changes in oral microbiocenosis. The purposes of the study is a clinical and microbiological assessment of the effectiveness of the use of various drugs for difficult teething, as well as a comparative assessment of the effect of these drugs on local and general symptoms of teething and oral microbiocenosis in children. >. Children with difficult teething (40 people each) aged from 5 months to 2 years were selected in 3 clinical groups. To assess the dynamics of the dental status and the state of oral microbiocenosis, clinical and microbiological (laboratory) research methods were performed for all the subjects. During 8 days children got treatment for managment of symptoms of teeth eruption: Dantinorm Baby (inside intake of oral solution), Calgel (locally on the gums), Viburgel (locally on the gums), and then a repeat study was performed. >. According to the results of the conducted studies and statistical data processing, it was found that the disappearance of local symptoms of difficult teething was more pronounced in the group of children in whose treatment the drug Dantinorm Baby was used (92% of cases). Against the background of the use of all drugs, the number of cariesogenic streptococci S. mutans decreased, and when using Dantinorm Baby — both S. mutans (from 95 to 80%) and A. naeslundii (from 10 to 0%) and some periodontopathogenic species (P. intermedia — from 10 to 3%). The effect of the drug Dantinorm Baby is accompanied by its normalizing effect on oral microbiocenosis.

Key words:

difficult eruption, oral microbiocenosis, cariesogenic streptococci, periodontopathogenic species

For Citation

[1]
Tsarev V.N., Kiselnikova L.P., Podporin M.S., Balafendieva F.M. Comparative evaluation of the effect of topical and systemic dosage forms on oral microbiocenosis in difficult eruption of temporary teeth. Clinical Dentistry (Russia).  2022; 25 (4): 44—49. DOI: 10.37988/1811-153X_2022_4_44

References

  1. Roulias P., Kalantzis N., Doukaki D., Pachiou A., Karamesinis K., Damanakis G., Gizani S., Tsolakis A.I. Teeth eruption disorders: A critical review. Children (Basel). 2022; 9 (6): 10. PMID: 35740708.
  2. Hanisch M., Hanisch L., Kleinheinz J., Jung S. Primary failure of eruption (PFE): a systematic review. Head Face Med. 2018; 14 (1): 5. PMID: 29544499
  3. Kazyukova T.V., Radtsig E.Yu., Pankratov I.V. Symptoms of eruption of milk teeth and possible ways of pharmacological action. Russian Medical Journal. 2015; 22: 1342—1344 (In Russ.). eLIBRARY ID: 25280880
  4. Zaplatnikov A.L., Kasyanova A.N., Maikova I.D. Teething syndrome in infants: a new look at the old problem. Russian Medical Journal. 2018; 5—2: 68—71 (In Russ.). eLIBRARY ID: 36578902
  5. Bogdanova N.A., Zueva T.E. How to help a child with teething? A new look at an old problem. Medical Council. 2019; 11: 50—55 (In Russ.). eLIBRARY ID: 38570677
  6. Zakharova I.N., Kholodova I.N., Dmitrieva Y.A., Morozova N.V., Mozzhukhina M.V., Kholodov D.I. Can the physiological process of teething in babies be abnormal?. Medical Council. 2016; 1: 30—35 (In Russ.). eLIBRARY ID: 25482551
  7. Kovalev D.V., Kovaleva I.V. How to relieve teething syndrome in babies. Lechaschi Vrach. 2021; 6: 9—12 (In Russ.). eLIBRARY ID: 46534410
  8. Macknin M.L., Piedmonte M., Jacobs J., Skibinski C. Symptoms associated with infant teething: a prospective study. Pediatrics. 2000; 105 (4 Pt 1): 747—52. PMID: 10742315
  9. Tsang A.K.L. Teething, teething pain and teething remedies. International Dentistry SA. 2010; 12 (5): 48—61.
  10. Markman L. Teething: facts and fiction. Pediatr Rev. 2009; 30 (8): e59—64. PMID: 19648257
  11. Faustova M.O., Ananieva M.M., Basarab Y.O., Dobrobolska O.V., Vovk I.M., Loban’ G.A. Bacterial factors of cariogenicity (literature review). Wiad Lek. 2018; 71 (2 pt 2): 378—382. PMID: 29786589
  12. Tsarev V.N., Toma E.I., Kiselnikova L.P., Podporin M.S. Dynamics of the main parameters of the oral microbiota in preschool children with dental caries against the background of long-term use of probiotics. The Dental Institute. 2022; 2 (95): 25—27 (In Russ.). eLIBRARY ID: 49264993
  13. Nascimento M.M., Alvarez A.J., Huang X., Hanway S., Perry S., Luce A., Richards V.P., Burne R.A. Arginine metabolism in supragingival oral biofilms as a potential predictor of caries risk. JDR Clin Trans Res. 2019; 4 (3): 262—270. PMID: 31039043
  14. Kiselnikova L.P., Tsarev V.N., Toma E.I., Podporin M.S. Microbiocenosis of the oral cavity of children: clinical and microbiological characteristics and correction with probiotics based on salivary streptococci. Clinical Dentistry (Russia). 2021; 4: 24—29 (In Russ.). eLIBRARY ID: 47475741
  15. Balmasova I.P., Tsarev V.N., Yanushevich O.O., Maev I.V., Mkrtumyan A.M., Arutyunov S.D. Microecology of the periodontium. Relationship between local and systemic effects. Moscow: Practical medicine, 2021. Pp. 15—55 (In Russ.).
  16. Ushakov R.V., Tsarev V.N., Ashueva A.Zh., Ushakov A.R., Tsareva T.V. Prevention of complications of iatrogenic transient bacteremia in dental practice. International Dental Review. 2021; 3 (96): 4—11 (In Russ.). eLIBRARY ID: 46594602
  17. Memarpour M., Soltanimehr E., Eskandarian T. Signs and symptoms associated with primary tooth eruption: a clinical trial of nonpharmacological remedies. BMC Oral Health. 2015; 15: 88. PMID: 26215351
  18. Sorokina A.V., Alekseeva S.V., Miroshkina I.A., Kachalov K.S., Zaharov A.D., Alekseev I.V., Lapizkaya A.S. Study the subchronic toxicity of the drug Dantinorm Baby. Pharmacokinetics and Pharmacodynamics. 2020; 3: 52—60 (In Russ.). eLIBRARY ID: 46176361

Downloads

Received

October 29, 2022

Accepted

December 6, 2022

Published on

December 21, 2022