DOI:

10.37988/1811-153X_2022_1_44

Clinical evaluation of Superlymph a local immunomodulator in the treatment of patients with a slight chronic generalized periodontitis

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Authors

  • A.I. Grudyanov 1, PhD in Medical Sciences, full professor of the Periodontology Department
    ORCID: 0000-0003-3818-9307
  • E.V. Fomenko 1, PhD in Medical Sciences, physician at the Periodontology Department
    ORCID: 0000-0003-4747-8039
  • I.S. Berkutova 1, PhD in Medical Sciences, deputy chief physician in outpatient care
    ORCID: 0000-0002-9090-9917
  • 1 Central Research Institute of Dental and Maxillofacial Surgery, 119021, Moscow, Russia

Abstract

The anti-inflammatory efficacy of the use of the immunomodulatory drug Superlymph® in the form of alginate plates for the oral cavity in the treatment of slight severity chronic generalized periodontitis of was determined.
Materials and methods.
2 equal randomized groups of 30 patients each with mild chronic periodontitis were created. In accordance with the treatment protocol, all patients underwent professional oral hygiene: dental deposits were removed with the help of the Piezon Master 400 ultrasound machine, roots were sanded and polished, motivation for high-quality individual oral hygiene was carried out with monitoring 1 time a week. In the main group, patients additionally applied resorbable plates of the drug Superlymph to the gum 3 times a day for 10 days. The quantitative assessment of the periodontal condition was carried out using the Mulleman and PMA indices.
Results.
All patients showed positive dynamics of the indices of the Mulleman and PMA indices (after 7, 21 days), however, in the main group with the drug Superlimf, there was a more intense decrease in indicators on 7 and 21 days. The Mulleman index, having been 3.0 before treatment in both groups, decreased to 1.7 on the 7th day in the main group (2.0 in the control group), to 0.8 on the 21st day (1.0 in the control group).
Conclusion.
Local application of alginate plates for the oral cavity Superlymph indicates a pronounced anti-inflammatory result and enhances the effect of treatment of patients with slight chronic generalized periodontitis.

Key words:

periodontitis, cytokines, immunomodulator, Superlymph

For Citation

[1]
Grudyanov A.I., Fomenko E.V., Berkutova I.S. Clinical evaluation of Superlymph a local immunomodulator in the treatment of patients with a slight chronic generalized periodontitis. Clinical Dentistry (Russia).  2022; 25 (1): 44—47. DOI: 10.37988/1811-153X_2022_1_44

References

  1. Grudyanov A.I. Periodontal diseases. Moscow, 2021. 411 p. (In Russ.).
  2. Puzin S.N., Pryanikov I.V., Vanchenko N.B., Karakov K.G., Shurgaya M.A. Medical and social aspects of chronic general parodontitis. Medical and Social Expert Evaluation and Rehabilitation. 2018; 3—4: 129—133 (In Russ.). eLIBRARY ID: 37188622
  3. Yanushevich O.O., Dmitrieva L.A. (eds) Periodontology: National guidelines. Moscow: GEOTAR-Media, 2018. 752 p. (In Russ.).
  4. Puzin M.N., Kiparisova Ye.S., Vagner V.D., Mamedova L.A., Podoynikova M.N., Gnezditsky V.V. Clinical features of chronic generalized periodontitis. Russian Journal of Dentistry. 2008; 3: 24—28 (In Russ.). eLIBRARY ID: 11633324
  5. Chang E.H., Giaquinto P., Huang J., Balashova N.V., Brown A.C. Epigallocatechin gallate inhibits leukotoxin release by Aggregatibacter actinomycetemcomitans by promoting association with the bacterial membrane. Mol Oral Microbiol. 2020; 35 (1): 29—39. PMID: 31816197
  6. Gulyaeva OksanaA., Salyakhova GulsinaA., Tukhvaullina DamiraN., Mamatov YunusM., Ilchigulova OlesyaE. The role of non-drug methods in the supportive periodontal therapy complex. Actual Problems in Dentistry. 2017; 1: 65—69 (In Russ.). eLIBRARY ID: 29256725
  7. Grudyanov A.I., Fomenko E.V., Kalyuzhin O.V. Clinical effectiveness of an immunomodulatory drug based on a muramylpeptide composition in the treatment of patients with chronic generalized periodontitis. Stomatology. 2020; 6: 24—27 (In Russ.). eLIBRARY ID: 44298768
  8. Zorina O.A., Gankovskaya L.V., Balykin R.A., Ivanyushko T.P., Svitich O.A., Grechenko V.V. Positive effect of autologous immune peptides applications in the surgical treatment of inflammatory-destructive periodontal lesions. Russian Journal of Dentistry. 2017; 1: 4—7 (In Russ.). eLIBRARY ID: 28869010
  9. Koreeva N.V., Dobrokhotova Iu.É. Topical cytokinotherapy in gynecological practice (a review). Russian Journal of Human Reproduction. 2013; 4: 21—26 (In Russ.). eLIBRARY ID: 20282970
  10. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003; 3 (9): 710—20. PMID: 12949495
  11. Selsted M.E., Ouellette A.J. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005; 6 (6): 551—7. PMID: 15908936
  12. Kovalchuk L.V., Gvozdeva Yu.V., Chernousova L.N., Gankovskaya L.V., Smirnova T.G., Larionova E.E., Sokolova E.V., Levchenko V.A. Antimycobacterial effect of natural cytokines complex and antimicrobial peptides in vitro and ex vivo. Russian Journal of Immunology. 2012; 2: 184—193 (In Russ.). eLIBRARY ID: 19313606
  13. Pustovalova R.A., Petrova M.B. The immunocorrecting effect of the “Superlymph” preparation on the cutaneous wound healing. Morphology. 2008; 2: 110b (In Russ.). eLIBRARY ID: 11642027
  14. Kovalchuk L.V., Gankovskaya L.V., Yarigin N.V., Yarema V.I., Doctorov A.A., Dolgina E.N., Chadaev A.P., Alichanov Ch.A. “Superlymph” in complex treatment of complicated wound process. Immunopathology, Allergology, Infectology. 2005; 2: 33—43 (In Russ.). eLIBRARY ID: 21144137

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Received

November 24, 2021

Accepted

March 15, 2022

Published on

March 1, 2022