DOI:

10.37988/1811-153X_2021_4_36

Antidepressants efficacy in glossodynia comprehensive treatment

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Authors

  • E.A. Makarova 1, postgraduate at the Dentistry Department
    ORCID: 0000-0003-0048-2110
  • A.V. Shumsky 1, PhD in Medical Sciences, full professor of the Dentistry Department
    ORCID: 0000-0001-8305-6023
  • 1 Medical University “REAVIZ”, 443099, Samara, Russian Federation

Abstract

We evaluated the efficacy of comprehensive treatment of glossodynia with different antidepressants on the basis of psychoemotional state indicators of patients and analysis of side effects of the drugs. Materials and
Methods.
Patients aged 40 to 68 years (n=45) with diagnosed glossodynia were divided into 3 groups of 15 people depending on which antidepressant was used in the treatment regimen. Group I received amitriptyline (25 mg), Group II received Duloxetine (60 mg), and group III received Sertraline (100 mg). Pain level was assessed with the help of visual analog scale. Psychoemotional state was determined using a personality anxiety scale. Patients were questioned about side effects of the prescribed antidepressants. Results were compared before treatment and at the end of the course in 1 month.
Results.
Pain and anxiety levels in all groups after treatment were statistically significantly different from pre-treatment levels (p<0.001). Thus, group I patients showed 60.3 and 35.1% reduction of anxiety and pain levels respectively, in group II — 61.6 and 37.2%, in group III — 62.1 and 42.7%. The number of side effects in group I was almost twice as high as in groups II (less frequent) and III (almost always), but the differences were statistically insignificant.
Conclusion.
The use of various groups of antidepressants in the treatment of glossodynia is effective, contributes to the correction of patients' psychoemotional state due to the decrease of pain and anxiety. However, it is preferable to prescribe medications of the latest generation due to a lower number of side effects.

Key words:

glossalgia, scalded mouth syndrome, glossodynia, burning tongue syndrome, antidepressants

For Citation

[1]
Makarova E.A., Shumsky A.V. Antidepressants efficacy in glossodynia comprehensive treatment. Clinical Dentistry (Russia).  2021; 24 (4): 36—41. DOI: 10.37988/1811-153X_2021_4_36

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Received

June 18, 2021

Accepted

November 28, 2021

Published on

December 1, 2021