DOI:

10.37988/1811-153X_2020_3_93

Clinical-laboratory evaluation of osteoplastic material Klipdent. A review

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Authors

  • A.A. Romanenko 1, 2, junior researcher; head of the Quality assurance Division
  • V.V. Chuev 3, 4, PhD in Medical Science, chief physician; associate professor of the Therapeutic dentistry Department
  • A.A. Buzov 1, 5, PhD in Engineering, technical director; technical director
  • V.P. Chuev 1, 4, Grand PhD in Engineering, general director; head of the Medical and technical systems department
  • 1 “VladMiVa Experimental Plant” JSC, 308023, Belgorod, Russia
  • 2 “Belfarmamed” LLC, 308023, Belgorod, Russia
  • 3 “VladMiVa Dental Centre” LLC, 308023, Belgorod, Russia
  • 4 Belgorod State University, 308015, Belgorod, Russia
  • 5 “Nanoapatit” LLC, 308023, Belgorod, Russia

Abstract

Objective — Clinical and laboratory evaluation was carried out to evaluate the level of clinical performance and safety of the Klipdent osteoplastic material (VladMiVa). Methods. Analysis and evaluation of clinical data on a medical device, represented by publications of Russian and foreign scientific publications and dissertations, reflecting the results of clinical and laboratory studies of the Klipdent material. Results: Laboratory studies indicate the effectiveness of the use of Klipdent to replace bone defects and accelerate bone tissue regeneration processes compared to the normal course. In clinical studies, the effectiveness of using various forms of release Klipdent is shown. In the practice of surgical treatment of fractures of the lower jaw, refined teeth, and jaw cysts. Clinically substantiated the effectiveness of the use of this material in the treatment of patients with chronic generalized periodontitis, with resection of the apex of the root of the tooth and with direct dental implantation. Klipdent-gel is effective in the treatment of periodontal diseases and for the healing of postoperative wound defect, because helps to reduce pain, reduce the inflammatory response, and accelerate the timing of epithelization. Conclusions. Clinical performance and safety of the Klipdent material have been confirmed, used in dentistry and maxillofacial surgery to replace bone defects and accelerate bone regeneration.

Key words:

osteoplastic material, resorbable membrane, bone regeneration, Klipdent

For Citation

[1]
Romanenko A.A., Chuev V.V., Buzov A.A., Chuev V.P. Clinical-laboratory evaluation of osteoplastic material Klipdent. A review. Clinical Dentistry (Russia).  2020; 3 (95): 93—99. DOI: 10.37988/1811-153X_2020_3_93

References

  1. Haritonov D. Yu., Domashevskaya E.P., Azarova E.A., Golo­schapov D.L. The comparison of morphological and structural characteristics of the human mandibular bone tissue and the osteoplastic material “Klipdent”, “Bioplast-dent”. — Applied and IT Research in Medicine. — 2014; 2: 63—7 (In Russ.).
  2. Kharitonov D.Yu., Azarova Ye.A., Azarova O.A. Comparative characteristics of morphological structure osteoplastic materials of various origin and bone tissue of man. — Scientific-medical Bulletin of Central black earth region. — 2017; 69: 3—6 (In Russ.).
  3. Lesnikova I.N., Azarova E.A. Morphological substantiation of the use of osteoplastic materials «Bioplast-dent» and Klipdent in the complex implementation of jaw fractures. — Proceedings of the 8 interregion. scientific-practical conf. “Modern technologies for the treatment of dental diseases”. — Ryazan, 2013. — P. 172—175 (In Russ.).
  4. Kharitonov D.Yu., Domashevskaya E.P., Azarova E.A., Goloschapov D.L. The evaluation of the results of scanning electron microscopy in the study of the morphological structure of the osteoplastic material “Clipdent” and native human bone. — Modern Problems of Science and Education. — 2014; 6: 1074 (In Russ.).
  5. Gushin M.S., Goloschapov D.L., Seredin P.V., Domashevskaya E.P., Azarova E.A., Haritonov D.Y. Comparative characteristics of dental composites and materials based on hydroxyapatite — Proceedings of the FAGRAN-2015 conference “Physico-chemical processes in condensed media and interphase boundaries”. — Voronezh, 2015. — P. 186—187 (In Russ.).
  6. Goloschapov D.L., Gushin M.S., Seredin P.V., Domashevskaya E.P., Lenshin A.S., Maraeva E.V. Comparative characteristics of synthetic and biogenic apatites. — Proceedings of the 71st Russian scientific and technical conference dedicated to Radio Day. — Saint-Petersburg, 2016. — P. 322—324 (In Russ.).
  7. Korotkikh N.G., Bugrimov D.Y. Justification of osteoplastic preparation “Bioplast-dent” and “Klipdent” in the experiment. — Scientific-medical Bulletin of Central black earth region. — 2013; 52: 200—2 (In Russ.).
  8. Korotkikh N.G., Azarova E.A. Experimental substantiation of the use of Bioplast-dent and Klipdent in a comprehensive study of jaw fractures. — Proceedings of the 17th conf. maxillofacial surgeons and dentists “New technologies in dentistry”. — Saint-Petersburg, 2013. — P. 90 (In Russ.).
  9. Korotkikh N.G., Kharitonov D.Y., Azarova E.A., Stepanov I.V. Experimental substantiation of the use of materials “Klipdent”, “Bioplast-dent” at the substitution of bone defects after traumatic removal of teeth. — Journal of New Medical Technologies, eEdition. — 2014; 1: 67 (In Russ.).
  10. Korotkih N.G., Bugrimov D.J., Lesnikova I.N., Azarova E.A. Justification of osteoplastic preparation «Bioplast-dent» and Klipdent in the experiment. — Proceedings of the I international conference “Morphological aspects of security of life activities”. — Voronezh, 2013. — P. 148 (In Russ.).
  11. Borisenko A.V., Kodlubovskiy Yu. Yu., Vit V.V. The histological study of regeneration of mandibular osseous tissue at the influence of tribasic calcium phosphate and hyaluronic acid. — Stomatological Bulletin. — 2015; 1 (90): 6—10 (In Russ.).
  12. Lubchenko A.V., Kravtsov N.S. Study of the properties of osteoplastic materials Klipdent PL and Klipdent MK (“Vladmiva”, Russia) experimental. — Proceedings of the IX International scientific-practical conference “Dentistry of the Slavic states”. — Belgorod, 2016. — P. 268—270 (In Russ.).
  13. Lyubchenko A.V., Kravtsov N.S. The study of reparative processes of bone tissue of rats with using material Klipdent PL and membrane Klipdent MK (experimentally-anatomical investigation). — Ukrainian Dental Almanac. — 2016; 3-2: 7—10 (In Russ.).
  14. Lyubchenko A.V., Kravtsov N.S., Posohova V.F., Likova I.V., Chuev V.V., Klukin B.V. Study of reparative processes of bone tissue of rats using osteoplastic material Klipdent PL and membrane Klipdent MK of company “Vladmiva” (Russia) (experimental-morphological study). — The Dental Institute. — 2018; 2 (79): 104—5 (In Russ.).
  15. Azarova E.A. Clinical and experimental rationale for the use of Bioplast-dent, Klipdent in the complex treatment of fractures of the jaw and intraosseous formations of the maxillofacial area: master‘s thesis. —Voronezh, 2015. — 22 p. (In Russ.).
  16. Korotkikh N.G., Kharitonov D.Y., Azarova E.A. Evaluation of the results of the use of osteoplastic materials Klipdent, Bioplast-dent in the complex treatment of radicular cysts of the jaw. —Youth innovational vestnik. — 2014; 3 (2): 178 (In Russ.).
  17. Lesnikova I.N., Azarova E.A. Clinical and experimental justification for the use of osteoplastic materials Klipdent, Bioplast-dent when filling bone defects after removal of the retarded third molars. — Marine doctor‘s bulletin (Sevastopol). — 2014; 13: 78 (In Russ.).
  18. Aphadze A.R. Study of the effectiveness of using bacteriophages in the surgical treatment of patients with inflammatory and destructive periodontal lesions: master‘s thesis. — Moscow, 2016. — 132 p. (In Russ.).
  19. Abdullaeva N.K., Sharipova T.V. Comparative efficiency of using osteoplastic materials after operating the resistance of the upper of the tooth root in treatment of destructive periodontitis forms. — International Student Scientific Bulletin. — 2017; 5: 25 (In Russ.). eLIBRARY ID: 30317733
  20. Likova I.V., Posohova V.F., Chuev V.V., Kazakova V.S., Klukin B.V. The effectiveness of the use of demineralized bone blocks “Bioplast dent” in dentistry. — Proceedings of the XI International scientific-practical conference “Dentistry of the Slavic states”. — Belgorod, 2018. — P. 172—174 (In Russ.).
  21. Liubchenko A.V., Kravtsov N.S. The application of direct dental implantation technique with total defects on the lower jaw with the use of the synthetic osteoplastic material “Klipdent PL” and the membrane “Klipdent MK”. — Ukrainian Dental Almanac. — 2018; 1: 64—7 (In Russ.).
  22. Lyubchenko A.V., Kravtsov N.S. The use of the synthetic osteoplastic material “Klipdent PL” for direct dental implantation with included defects on the upper jaw. — Problems of Uninterrupted Medical Training and Science. — 2018; 1(28): 57—61 (In Russ.).
  23. Rachkov A.A. The study of the composition of the microbial flora in the operating area using barrier membranes. — Proceedings of the 73rd science session “Advances in fundamental, clinical medicine and pharmacy“. — Vitebsk, 2018. — P. 176—178 (In Russ.).
  24. Maksimova N.V. Comparative evaluation of the postoperative period with various methods of deepening the vestibule of the oral cavity in patients with complete absence of teeth. — Proceedings of V International scientific conference “General question of world science”. — Brussels, 2018. — P. 31—34 (In Russ.).
  25. Maksimova N.V. Evaluation of the effectiveness of various techniques for correcting the vestibule of the oral cavity at the toothless mandible in preparation for prosthetics. — Proceedings of the VI International correspondence scientific specialized conference «International scientific review of the problems of natural sciences and medicine». — Boston, USA, 2018. — P. 10—13 (In Russ.).
  26. Maksimova N.V., Astashina N.B. The possibility of application of the preparation “Clipdent gel” with open methods of deepening vestibule of the mouth on the edentulous lower jaw. — Ural Medical Journal. — 2018; 12 (167): 155—8 (In Russ.).
  27. Sheveleva I.V., Tyo E.A., Asmandyarova A.D. Comparative evaluation of the use of local dosage forms of chlorhexidine in the treatment of periodontal disease. — Proceedings of the All-Russian scientific-practical conference “A topical issues of dentistry”. — Kemerovo, 2019. — P. 134—137 (In Russ.).
  28. Vanchenko N.B., Abdulahove D.A., Solovieva O.A., Sargisyan A.E., Kasimova G.V. Regenerative therapy of inflammatory diseases of periodontal tissues. — Proceedings of the 54th Russian Dental Scientific-Practical Conference «Modern methods of diagnosis, treatment, and prevention of dental diseases». — Stavropol, 2018. — P. 206—208 (In Russ.).

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Published on

September 15, 2020