DOI:
10.37988/1811-153X_2020_3_24Clinical and diagnostic aspects and approach to the treatment of oral leukoplakia
Downloads
Abstract
The article presents the clinical and diagnostic aspects of oral leukoplakia and treatment approaches, depending on the clinical form of the disease. The aim of the study was to study the effectiveness of the treatment of verrucous form of oral leukoplakia using laser ablation and collagen-based drug. The study conducted a clinical examination and treatment of 28 patients (17 women and 11 men) aged 45 to 64 years with a verrucous form of oral leukoplakia, which were divided into two groups — the main (15 people) and a comparison group (13 people). In the main group, the lesion site was excised by laser ablation; after surgery collagen-based drug was applied to the wound surface. In the comparison group (12 people), the lesion site was excised with scalpel, and after surgery solcoseryl-based drug was applied to the wound surface. The results of observation in the postoperative period indicate reduction in the time of wound surface epithelization after the use of laser ablation and a collagen-based drug. This opens new possibilities in the treatment of verrucous form of oral leukoplakia.
Key words:
oral leukoplakia, laser ablation, collagen-based drugFor Citation
References
- Kosjuga S.Ju. Leukoplakia. — In.: Uspenskaja O.A., Zhulev E.N. (eds.) Diseases of the oral mucosa. — Nizhnij Novgorod, 2017. — P. 55—84 (In Russ.).
- Waal I. Oral leukoplakia; a proposal for simplification and consistency of the clinical classification and terminology. — Med Oral Patol Oral Cir Bucal. — 2019; 24 (6): e799-e803. PMID: 31655843
- Waal I. Oral leukoplakia: A diagnostic challenge for clinicians and pathologists. — Oral Dis. — 2019; 25 (1): 348—9. PMID: 30203899
- Modina T.N., Bolbat M.V., Dyatlova Yu.Yu. Soft leukoplakia. — Clinical Dentistry (Russia). — 2013; 3 (67): 46—50 (In Russ.).
- Rabinovich O.F., Rabinovich I.M., Semkin V.A., Abramova E.S., Umarova K.V., Agapitova L.P., Bezrukov A.A. Evaluating the effectiveness of complex treatment of patients with verrucous leukoplakia of the oral mucosa. — Clinical Dentistry (Russia). — 2016; 1 (77): 32—5 (In Russ.).
- Ron’ G.I., Kostromskaja N.N., Chernysheva N.D. Leukoplakia of the oral mucosa: aspects of clinical diagnosis and treatment. — Actual Problems in Dentistry. — 2006; 2: 3—7 (In Russ.).
- Babichenko I.I., Ivina A.A., Rabinovich O.F., Rabinovich I.M., Togonidze A.A. Papillomavirus in the genesis of oral leukoplakia. — Archive of Pathology. — 2014; 1: 32—6 (In Russ.).
- Rabinovich O.F., Rabinovich I.M., Togonidze A.A., Bezrukov A.A., Agapitova L.P. Anti-viral therapy application in comprehensive treatment of patients with verruciform leukokeratosis. — Clinical Dentistry (Russia). — 2017; 1 (81): 16—9 (In Russ.).
- Gileva O.S., Libik T.V., Pozdnyakova A.A., Satyukova L.Y. Precancerous lesions in structure of oral mucosa diseases (according to medical advisory data). — Actual Problems in Dentistry. — 2013; 2: 3—9 (In Russ.).
- Iocca O., Sollecito T.P., Alawi F., Weinstein G.S., Newman J.G., De Virgilio A., Maio P.D., Spriano G., López S.P., Shanti R.M. Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype. — Head Neck. — 2020; 42 (3): 539—55. PMID: 31803979
- Torrejon-Moya A., Jané-Salas E., López-López J. Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review. — J Oral Pathol Med. — 2020; 49 (5): 404—8. PMID: 31990082
- Lukinyh L.M., Tiunova N.V., Zhdanova M.L. Precancerous diseases of the oral mucosa and red border of the lips. — N. Novgorod, 2015. — 88 p. (In Russ.).
- Kosjuga S.Ju., Voinova S.O., Galkin K.S., Bogomazov I.D. Risk factors for leukoplakia in adolescents. — Dental Forum. — 2019; 4 (75): 49—50 (In Russ.).
- Leukoplakia. Clinical recommendations (treatment protocols). — M., 2013 (In Russ.).
- Potekaev N.S., Potekaev S.N., Potekaev N.N., Zhukova O.V. Hairy leukoplakia as a marker of HIV infection and AIDS. — Russian Journal of Clinical Dermatology and Venereology. — 2018; 17 (4): 114—9 (In Russ.).
- Muraev A.A., Volodina E.V., Ivanov S.Yu., Gnuchev N.V., Georgiev G.P., Larin S.S. Leukoplakia of the oral mucosa: classification, histopathology, diagnosis and treatment. — Problems in Oncology. — 2013; 59 (5): 548—54 (In Russ.).
- Warnakulasuriya S., Johnson N.W., Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. — J Oral Pathol Med. — 2007; 36 (10): 575—80. PMID: 17944749
- Bulgakova N.N., Volkov E.A., Pozdnyakova T.I. Autofluorescent somatoscope as a method of oncoscience diseases of the oral mucosa. — Russian Journal of Dentistry. — 2015; 19 (1): 27—30 (In Russ.).
- Rabinovich O.F., Babichenko I.I., Rabinovich I.M., Togonidze A.A. Methods of complex diagnostics of oral leukoplakia. — Stomatology. — 2014; 93 (5): 19—22 (In Russ.).
- Syomkin V.A., Rabinovich O.F., Agapitova L.P., Bezrukov A.A., Babichenko I.I. Diagnostic value of optical coherence tomography for oral leukoplakia assessment. — Stomatology. — 2018; 97 (1): 37—9 (In Russ.).
- Rabinovich O.F., Abramova E.S., Togonidze A.A. Clinic, diagnostic and treatment of various forms of a leykoplakiya. — Stomatology. — 2014; 93 (5): 75—81 (In Russ.).
- Chen Q., Dan H., Tang F., Wang J., Li X., Cheng J., Zhao H., Zeng X. Photodynamic therapy guidelines for the management of oral leucoplakia. — Int J Oral Sci. — 2019; 11 (2): 14. PMID: 30971683
- Li Y., Wang B., Zheng S., He Y. Photodynamic therapy in the treatment of oral leukoplakia: A systematic review. — Photodiagnosis Photodyn Ther. — 2019; 25: 17—22. PMID: 30391342
- Zyablitskaya K.V., Vorobyova E.N., Tokmakova S.I., Sharlaeva E.A., Sokolova G.G., Batanina I.A., Bondarenko O.V. Ozone therapy in complex treatment of leukoplakia of oral mucosa. — Medical Alphabet. — 2018; 2 (339): 11—15 (In Russ.).
- Yaremenko A.I., Kirillov A.L., Cherednikova I.A., Ovsepian T.N. Cryotherapy for treatment the oral mucosa extensive lesions. — Parodontologiya. — 2018; 1 (86): 86—9 (In Russ.).
- Durnovo E.A., Yanova N.A., Khomutinnikova N.E. Optimization of the surgical treatment of diseases of the oral mucosa. — Nizhny Novgorod Medical Journal. — 2008; 2 (2): 236—9 (In Russ.).
- Jagtap B., Bhate K., Santhoshkumar S.N. Low level laser therapy reduces oral leukoplakia lesion size: Results from a preliminary study. — Oral Oncol. — 2018; 85: 108—1. PMID: 30098877
- Matulić N., Bago I., Sušić M., Gjorgievska E., Knežević A.K., Gabrić D. Comparison of Er: YAG and Er,Cr: YSGG Laser in the Treatment of Oral Leukoplakia Lesions Refractory to the Local Retinoid Therapy. — Photobiomodul Photomed Laser Surg. — 2019; 37 (6): 362—8. PMID: 31081716
- Lauritano D., Lucchese A., Gabrione F., Stasio D.D., Rangil J.S., Carinci F. The Effectiveness of Laser-Assisted Surgical Excision of Leukoplakias and Hyperkeratosis of Oral Mucosa: A Case Series in A Group of Patients. — Int J Environ Res Public Health. — 2019; 16 (2): 210. PMID: 30642122
- Palmerín-Donoso A., Cantero-Macedo A.M., Tejero-Mas M. [Oral leukoplakia]. — Aten Primaria. — 2020; 52 (1): 59—60 (In Spanish). PMID: 31029457