DOI:

10.37988/1811-153X_2019_1_66

The treatment of patients with hemiatrophy of the facial soft tissues due to scleroderma and patients with hemiatrophy after reconstructive operations using combined lipofilling methods

Authors

  • T.Z. Chkadua 1, PhD in Medical Sciences, head of the Reconstructive maxillofacial surgery, microsurgery and ectoprosthetics Department
  • Z.U. Visaitova 1, PhD in Medical Sciences, dental surgeon, researcher at the Maxillofacial surgery Division
  • O.O. Strukova 1, maxillofacial surgeon, postgraduate at the Reconstructive maxillofacial surgery, microsurgery and ectoprosthetics Division
  • E.K. Krechina 1, PhD in Medical Sciences, full professor of the Functional diagnostics Department
  • A.E. Hodyachij 1, radiologist, senior researcher
  • P.A. Belkov 2, dermatologist
  • L.I. Ysaj 3, PhD in Medical Sciences, associate professor, researcher
  • V.V. Garin 3, senior lecturer
  • 1 Central Research Institute of Dental and Maxillofacial Surgery, 119021, Moscow, Russia
  • 2 “Anta-med Group” LLC, 115114, Moscow, Russia
  • 3 Sechenov University, 119435, Moscow, Russia

Abstract

The basis of Central Research Institute of Dentistry and Maxillofacial Surgery in the period from 2015 to 2018 years there were 30 patients with primary hemiatrophy and patients with hemiatrophy after reconstructive operations who were examined and treated. The elimination of deformation of soft tissues was performed by combination of micro-, nano- and classical lipofilling in two stages with an interval of 6 months. To determine the deficit of tissue volume on the affected side before and at the treatment stages, a computer tomography was performed with the construction of the mathematical surface of the face. A study of the nature of the changes in the underlying structures in each group was carried out using ultrasound scanning and LDF studies. The use of non-invasive research methods allows us to track the dynamics of skin transformation. Based on the results of the treatment in the first and second groups, a combination of micro-, nano- and classical lipofilling did not only increase the volume and eliminate deformation, but also transform the quality of the skin. Thus, the combination of various lipofilling methods allowed to achieve a more stable result and increase the efficiency of treatment.

Key words:

micro- and nanofat, multipotent mesenchymal stem cells, hemiatrophy, fat tissue, microcirculation of the skin

For Citation

[1]
Chkadua T.Z., Visaitova Z.U., Strukova O.O., Krechina E.K., Hodyachij A.E., Belkov P.A., Ysaj L.I., Garin V.V. The treatment of patients with hemiatrophy of the facial soft tissues due to scleroderma and patients with hemiatrophy after reconstructive operations using combined lipofilling methods. Clinical Dentistry (Russia).  2019; 1 (89): 66—70. DOI: 10.37988/1811-153X_2019_1_66

References

  1. Tonnard P., Verpaele A., Peeters G., Hamdi M., Cornelissen M., Declercq H. Nanofat grafting: basic research and clinical applications. - Plast Reconstr Surg. - 2013; 132 (4): 1017-26.
  2. Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., Benhaim P., Lorenz H.P., Hedrick M.H. Multilineage cells from human adipose tissue: implications for cell-based therapies. - Tissue Eng. - 2001; 7 (2): 211-28.
  3. Rigotti G., Marchi A., Galiè M., Baroni G., Benati D., Krampera M., Pasini A., Sbarbati A. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. - Plast Reconstr Surg. - 2007; 119 (5): 1409-22.
  4. Bailey A.M., Kapur S., Katz A.J. Characterization of adipose-derived stem cells: an update. - Curr Stem Cell Res Ther. - 2010; 5 (2): 95-102.
  5. Zhou Y., Wang J., Li H., Liang X., Bae J., Huang X., Li Q. Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis. - Plast Reconstr Surg. - 2016; 137 (1): 44e-57e.
  6. Брусова Л.А. Устранение дефектов и деформаций лица имплантатами из силикона: дис. … к.м.н. - М., 1975. - 248 с.
  7. Неробеев А.И., Кобазев В.Э. Применение титансодержащих сетчатых имплантатов для устранения птоза мягких тканей лица при параличе мимической мускулатуры. - Клиническая стоматология. - 2017; 2 (82): 36-8.
  8. Yang X., Wu R., Bi H., Lu H., Jia Z., Jin X., Qi Z. Autologous fat grafting with combined three-dimensional and mirror-image analyses for progressive hemifacial atrophy. - Ann Plast Surg. - 2016; 77 (3): 308-13.
  9. Смбатян Б.С. Современные методы ушивания мягких тканей. - Клиническая стоматология. - 2010; 2 (54): 68-73.
  10. Чкадуа Т.З., Висаитова З.Ю., Струкова О.О. Комбинированные методы липофилинга в лечении пациентов с гемиатрофией мягких тканей челюстно-лицевой области. - Стоматология. - 2018; 2: 34.
  11. Веремеев А.В., Болгарин Р.Н., Петкова М.А., Кац Н., Нестеренко В.Г. Стромально-ваcкулярная фракция жировой ткани как альтернативный источник клеточного материала для регенеративной медицины. - Гены & клетки. - 2016; 1: 1-8.
  12. Баткаев Э.А., Галлямова Ю.А., Халед Х.А. Диффузная алопеция: методическое пособие. - М.: РМАПО, 2010.

Published on

March 1, 2019