DOI:

10.37988/1811-153X_2019_1_12

The relationship between genotypes of kallikrein-4 gene and dental caries implementation and course

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Authors

  • I.K. Lukashevich 1, assistant at the Pediatric dentistry, orthodontics and Dentistry diseases propaedeutics Department
  • E.G. Pomorgailo 1, PhD in Biological Sciences, full professor of the Pathological anatomy Department
  • I.L. Gorbunova 1, PhD in Medical Sciences, assistant professor of the Pediatric dentistry Department
  • I.R. Abramyan 2, dentist
  • 1 Omsk State Medical University, 644099, Omsk, Russia
  • 2 private practice

Abstract

On the comprehensive assessment of polymorphism of gene to regulate the formation of protein matrix - kallikrein-4 G2664153A and G2142А basis, the forecast of dental caries development in a case of carrying the allele A determining dysregulation of the tooth enamel mineralization process has been substantiated. This approach makes drawing up an individual plan of preventing dental caries be possible depending on the carrier of the genotype A/A of the kallikrein-4 gene at the mutation points G2664153A and G2142A. The criteria for forming dispensary observation groups are the allele A carrier of KLK4 gene at the mutation points G2664153A and G2142A, which indicates a high risk of tooth decay.

Key words:

kallikrein-4 gene, mutations, risk of tooth decay development, prevention

For Citation

[1]
Lukashevich I.K., Pomorgailo E.G., Gorbunova I.L., Abramyan I.R. The relationship between genotypes of kallikrein-4 gene and dental caries implementation and course. Clinical Dentistry (Russia).  2019; 1 (89): 12—15. DOI: 10.37988/1811-153X_2019_1_12

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Published on

March 1, 2019