Relations between intolerance to dental materials and hypersensitivity, cortisol level and stress

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Authors

  • I.U. Karpuk 1, к.м.н., доцент, докторант кафедры общей стоматологии с курсом ортопедической стоматологии, клинической иммунологии и аллергологии с курсом ФПК и ПК
  • 1 Витебский государственный медицинский университет

Abstract

The study explored the relationship of intolerance to dental materials (IDM) with hypersensitivity, cortisol level and stress. The study found that in patients with IDM, the level of cortisol in whole saliva (WS) was increased, and in patients of the control group it was not. It was shown that in patients with the presence of objective clinical symptoms of IDM and IgE antibodies to metals in blood, a significant decrease in the concentration of cortisol in the WS from 6.52 to 3.61 ng/ml occured 1 month after the removal of prosthetic constructions. The presence of a correlation between the concentration of cortisol and the presence of IgE antibodies to metals (Ni - ρ = 0.75, Co - ρ = 0.63 and with Cr - ρ = 0.41) indicates that the cause of the increase in cortisol levels in these patients is an allergy to the components of dental materials. In patients without objective clinical symptoms, but with complaints of IDM 1 month after the removal of orthopedic constructions, a decrease in the initially elevated cortisol level did not occur (7.23 ng/ml before removal, 6.47 ng/ml after), while the concentration of cortisol strongly ρ = 0,88) correlated with the indicator of mental tension (stress level). Therefore, the study of concentration of cortisol in WS before and 1 month after the removal of prosthetic constructions is a convenient and informative method for diagnosing endogenous hypercorticism in patients with IDM.

Key words:

hypersensitivity, stress, IgE-antibodies, cortisol, oral fluid, dental materials

For Citation

[1]
Karpuk I.U. Relations between intolerance to dental materials and hypersensitivity, cortisol level and stress. Clinical Dentistry (Russia).  2017; 2 (82): 52—58

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Published on

June 1, 2017