Аспекты этиологии и патогенеза рецидивирующего афтозного стоматита

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Авторы

  • О.Ф. Рабинович 1, д.м.н., зав. отделением заболеваний слизистой оболочки рта
  • Е.С. Абрамова 1, к.м.н., старший научный сотрудник отделения заболеваний слизистой оболочки рта
  • К.В. Умарова 1, к.м.н., научный сотрудник отделения заболеваний слизистой оболочки рта
  • И.М. Рабинович 1, д.м.н., профессор, зав. отделом терапевтической стоматологии
  • 1 ЦНИИСиЧЛХ

Аннотация

Обзор посвящен современному анализу данных отечественной и иностранной литературы в отношении этиологии и патогенеза рецидивирующего афтозного стоматита. Приведены сведения преимущественно за последние 5-10 лет. Данный обзор поможет врачам в понимании стратегии комплексного лечения данного заболевания.

Ключевые слова:

рецидивирующий афтозный стоматит, этиология

Для цитирования

[1]
Рабинович О.Ф., Абрамова Е.С., Умарова К.В., Рабинович И.М. Аспекты этиологии и патогенеза рецидивирующего афтозного стоматита. — Клиническая стоматология. — 2015; 4 (76): 8—13

Список литературы

  1. Барер Г.М., Ионов В.В. Состояние микробиоценоза слизистой полости рта при хроническом рецидивирующем афтозном стоматите. - Саthedra. - 2007; 4: 24-7.
  2. Вахрушина Е.В. Клинико-лабораторное обоснование иммунокорригирующей терапии больных с рецидивирующим афтозным стоматитом: дис. … к.м.н. - М., 2012. 177 c.
  3. Нижегородова Д.Б., Зафранская М.М. γδТ-лимфоциты: общая характеристика, субпопуляционный состав, биологическая роль и функциональные особенности. - Медицинская иммунология. - 2009; 2-3; 115-30.
  4. Рабинович И.М., Банченко Г.В., Рабинович О.Ф., Иванова Е.В., Сабанцева Е.Г., Ефимова О.И. Роль микрофлоры в патологии слизистой оболочки рта. - Стоматология. - 2002; 5: 48.
  5. Сорокина Е.В. Toll-подобные рецепторы и первичное распознавание патогена при дерматозах инфекционной и неинфекционной этиологии. - Иммунология, аллергология, инфектология. - 2012; 2: 6-15.
  6. Adler I., Muiño A., Aguas S., Harada L., Diaz M., Lence A., Labbrozzi M., Muiño J.M., Elsner B., Avagnina A., Denninghoff V. Helicobacter pylori and oral pathology: Relationship with the gastric infection. - World J Gastroenterol. - 2014; 20 (29): 9922-9935.
  7. Albanidou-Farmaki E., Deligiannidis A., Markopoulos A.K., Katsares V., Farmakis K., Parapanissiou E. HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance? - Int J Immunogenet. - 2008; 35 (6): 427-32.
  8. Albanidou-Farmaki E., Kayavis I.G., Polymenidis Z., Papanayotou P. HLA-A,B,C, and DR antigens in recurrent oral ulcers. - Ann Dent. - 1988; 47 (1): 5-8, 15.
  9. Albanidou-Farmaki E., Markopoulos A.K., Kalogerakou F., Antoniades D.Z. Detection, enumeration and characterization of T helper cells secreting type 1 and type 2 cytokines in patients with recurrent aphthous stomatitis. - Tohoku J Exp Med. - 2007; 212 (2): 101-5.
  10. Albanidou-Farmaki E., Poulopoulos A.K., Epivatianos A., Farmakis K., Karamouzis M., Antoniades D. Increased anxiety level and high salivary and serum cortisol concentrations in patients with recurrent aphthous stomatitis. - Tohoku J Exp Med. - 2008; 214 (4): 291-6.
  11. Bagg J., Williams B.D., Amos N., Dagalis P., Walker D.M. Absence of circulating IgG immune complexes in minor recurrent aphthous ulceration. - J Oral Pathol. - 1987; 16 (2): 53-6.
  12. Barile M.F., Graykowski E.A., Driscoll E.J. et al. L form of bacteria isolated from recurrent aphthous stomatitis lesions. - Oral Surg Oral Med Oral Pathol. - 1963; 16: 1395-1402
  13. Barnadas M.A., Remacha A., Condomines J., de Moragas J.M. Hematologic deficiencies in patients with recurrent oral aphthae. - Med Clin (Barc). - 1997; 109 (3): 85-7.
  14. Besu I., Jankovic L., Konic-Ristic A., Raskovic S., Besu V., Djuric M., Cakic S., Magdu I.U., Juranic Z. The role of specific cow’s milk proteins in the etiology of recurrent aphthous ulcers. - J Oral Pathol Med. - 2013; 42 (1): 82-8.
  15. Birek C., Grandhi R., McNeill K., Singer D., Ficarra G., Bowden G. Detection of Helicobacter pylori in oral aphthous ulcers. - J Oral Pathol Med. - 1999; 28: 197-203.
  16. Boggess K.A., Williamson H.O., Homm R.J. Influence of the menstrual cycle on systemic diseases. - Obstet Gynecol Clin North Am. - 1990; 17 (2): 321-42.
  17. Borra R.C., Andrade P.M., Silva I.D., Morgun A., Weckx L.L., Smirnova A.S, Franco M. The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray. - J Oral Pathol Med. - 2004; 33 (3): 140-6.
  18. Borra R.C., de Mesquita Barros F., de Andrade Lotufo M., Villanova F.E., Andrade P.M. Toll-like receptor activity in recurrent aphthous ulceration. - J Oral Pathol Med. - 2009; 38 (3): 289-98.
  19. Buño I.J., Huff JC, Weston W.L., Cook D.T., Brice SL. Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis. - Arch Dermatol. - 1998; 134 (7): 827-31.
  20. Cheng J., Malahias T., Brar P., Minaya M.T., Green P.H. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States cohort. - J Clin Gastroenterol. - 2010; 44 (3): 191-4.
  21. Dalghous A.M., Freysdottir J., Fortune F. Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet’s disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. - Scand J Rheumatol. - 2006; 35 (6): 472-5.
  22. Davatchi F., Tehrani-Banihashemi A., Jamshidi A.R., Chams-Davatchi C., Gholami J., Moradi M. The prevalence of oral aphthosis in a normal population in Iran: a WHO-ILAR COPCORD study. - Arch Iran Med. - 2008; 11: 207-9.
  23. Dolby A.E. Recurrent Mikulicz’s oral apthae. Their relationship to the menstrual cycle. - Br Dent J. - 1968; 124 (8): 359-60.
  24. Donatsky O. An immunofluorescence study on the cross-reaction between strep. 2a and human oral mucosa. - Scand J Dent Res. - 1975; 83 (2): 111-9.
  25. Donatsky O. Comparison of cellular and humoral immunity against streptococcal and adult human oral mucosa antigens in relation to exacerbation or recurrent aphthous stomatitis. - Acta Pathol Microbiol Scand C. - 1976; 84 (4): 270-82.
  26. Ferguson M.M., Wray D., Carmichael H.A., Russell R.I., Lee F.D. Coeliac disease associated with recurrent aphthae. - Gut. - 1980; 21 (3): 223-6.
  27. Fritscher A.M., Cherubini K., Chies J., Dias A.C. Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents. - J Oral Pathol Med. - 2004; 33 (3): 129-32.
  28. Gallina G., Cumbo V., Messina P., Caruso C. HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis. - Oral Surg Oral Med Oral Pathol. - 1985; 59 (4): 364-70.
  29. Gallo C., Barros F., Sugaya N., Nunes F., Borra R. Differential expression of toll-like receptor mRNAs in recurrent aphthous ulceration. - J Oral Pathol Med. - 2012; 41 (1): 80-5.
  30. Ghodratnama F., Riggio M.P., Wray D. Search for human herpesvirus 6, human cytomegalovirus and varicella zoster virus DNA in recurrent aphthous stomatitis tissue. - J Oral Pathol Med. - 1997; 26: 192-197.
  31. Ghodratnama F., Wray D., Bagg J. Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. - J Oral Pathol Med. - 1999; 28 (1): 12-5.
  32. Górska R. An epidemiological study of oral recurrent aphthous stomatitis (RAS) in children, adolescents and adults, aged 13-24. - Przeg Epid. - 1997; 51 (3): 339-47.
  33. Guimarães A.L., Correia-Silva J.de F., Sá A.R., Victória J.M., Diniz M.G., Costa F.de O., Gomez R.S. Investigation of functional gene polymorphisms IL-1beta, IL-6, IL-10 and TNF-alpha in individuals with recurrent aphthous stomatitis. - Arch Oral Biol. - 2007; 52 (3): 268-72.
  34. Guimarães A.L., de Sá A.R., Victória J.M., Correia-Silva J.F., Pessoa P.S., Diniz M.G., Gomez R.S. Association of interleukin-1beta polymorphism with recurrent aphthous stomatitis in Brazilian individuals. - Oral Dis. - 2006; 12 (6): 580-3.
  35. Hapa A., Aksoy B., Polat M., Aslan U., Atakan N. Does recurrent aphthous stomatitis affect quality of life? A prospective study with 128 patients evaluating different treatment modalities. - J Dermatolog Treat. - 2011; 22 (4): 215-20.
  36. Hasan A., Childerstone A., Pervin K., Shinnick T., Mizushima Y., Van der Zee R., Vaughan R., Lehner T. Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T-cells of patients with recurrent oral ulcers. - Clin Exp Immunol. - 1995; 99 (3): 392-7.
  37. Hasan A., Fortune F., Wilson A. et al. Role of gamma delta T cells in pathogenesis and diagnosis of Behcet’s disease. - Lancet. - 1996; 347: 789-94.
  38. Healy C.M., Thornhill M.H. An association between recurrent oro-genital ulceration and non-steroidal anti-inflammatory drugs. - J Oral Pathol Med. - 1995; 24 (1): 46-8.
  39. Hietanen J., Häyrinen-Immonen R., Al-Samadi A., Trokovic N., Koskenpato K., Konttinen Y.T. Recurrent aphthous ulcers - a Toll-like receptor-mediated disease? - J Oral Pathol Med. - 2012; 41 (2): 158-64.
  40. Jurge S., Kuffer R., Scully C., Porter S.R. Recurrent aphthous stomatitis. - Oral Dis. - 2006; 12 (1): 1-12.
  41. Kalkan G., Yigit S., Karakus N., Baş Y., Seçkin H.Y. Association between interleukin 4 gene intron 3 VNTR polymorphism and recurrent aphthous stomatitis in a cohort of Turkish patients. - Gene. - 2013; 527 (1): 207-10.
  42. Keenan A.V., Spivakovksy S. Stress associated with onset of recurrent aphthous stomatitis. - Evid Based Dent. - 2013; 14 (1): 25.
  43. Khan N.F., Saeed M., Chaudhary S., Khan N.F. Haematological parameters and recurrent aphthous stomatitis. - J Coll Physicians Surg Pak. - 2013; 23 (2): 124-7.
  44. Lewkowicz N., Lewkowicz P., Banasik M., Kurnatowska A., Tchórzewski H. Predominance of Type 1 cytokines and decreased number of CD4 (+)CD25 (+high) T regulatory cells in peripheral blood of patients with recurrent aphthous ulcerations. - Immunol Lett. - 2005; 99 (1): 57-62.
  45. Lewkowicz N., Lewkowicz P., Dzitko K., Kur B., Tarkowski M., Kurnatowska A., Tchórzewski H. Dysfunction of CD4+CD25high T regulatory cells in patients with recurrent aphthous stomatitis. - J Oral Pathol Med. - 2008; 37 (8): 454-61.
  46. Majorana A., Sapelli P.L., Malagoli A., Meini A., Pillan M.N., Duse M., Ugazio A.G. Celiac disease and recurrent aphthous stomatitis. The clinical and immunogenetic aspects. - Minerva Stomatol. - 1992; 41 (1-2): 33-40.
  47. Mansour-Ghanaei F., Asmar M., Bagherzadeh A.H., Ekbataninezhad S. Helicobacter pylori infection in oral lesions of patients with recurrent aphthous stomatitis. - Med Sci Monit. - 2005; 11 (12): 576-9.
  48. Miller M.F., Garfunkel A.A., Ram C.A., Ship I.I. The inheritance of recurrent aphthous stomatitis. Observations on susceptibility. - Oral Surg Oral Med Oral Pathol. - 1980; 49 (5): 409-12.
  49. Miyamoto N.T. Jr., Borra R.C., Abreu M., Weckx L.L., Franco M. Immune-expression of HSP27 and IL-10 in recurrent aphthous ulceration. J Oral Pathol Med. 2008; 37 (8): 462-7.
  50. Mumcu G., Cimilli H., Sur H. et al. Prevalence and distribution of oral lesions: a cross-sectional study in Turkey. - Oral Dis. - 2005; 11: 81-7.
  51. Nadendla L.K., Meduri V., Paramkusam G., Pachava K.R. Relationship of salivary cortisol and anxiety in recurrent aphthous stomatitis. - Indian J Endocrinol Metab. - 2015; 19 (1): 56-9.
  52. Natah S.S., Häyrinen-Immonen R., Hietanen J., Malmström M., Konttinen Y.T. Immunolocalization of tumor necrosis factor-alpha expressing cells in recurrent aphthous ulcer lesions (RAU). - J Oral Pathol Med. - 2000; 29 (1): 19-25.
  53. Natah S.S., Häyrinen-Immonen R., Hietanen J., Patinen P., Malmström M., Savilahti E., Konttinen Y.T. Increased density of lymphocytes bearing gamma/delta T-cell receptors in recurrent aphthous ulceration (RAU). - Int J Oral Maxillofac Surg. - 2000; 29 (5): 375-80.
  54. Natah S.S., Konttinen Y.T., Enattah N.S., Ashammakhi N., Sharkey K.A., Häyrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. - Int J Oral Maxillofac Surg. - 2004; 33 (3): 221-34.
  55. Nolan A., McIntosh W.B., Allam B.F., Lamey P.J. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. - J Oral Pathol Med. - 1991; 20 (8): 389-91.
  56. Ozdemir M., Acar H., Deniz F. et al. HLA-B*51 in patients with recurrent aphthous stomatitis. - Acta Derm Venerol. - 2009; 89: 202-3.
  57. Patil S., Reddy S.N., Maheshwari S., Khandelwal S., Shruthi D., Doni B. Prevalence of recurrent aphthous ulceration in the Indian Population. - J Clin Exp Dent. - 2014; 6 (1): 36-40.
  58. Pedersen A., Pedersen B.K. Natural killer cell function and number of peripheral blood are not altered in recurrent aphthous ulceration. - Oral Surg Oral Med Oral Pathol. - 1993; 76 (5): 616-9.
  59. Pedersen A., Ryder L.P. Gamma delta T-cell fraction of peripheral blood is increased in recurrent aphthos ulceration. - Clin Immunol Immunopathol. - 1994; 72 (1): 98-104.
  60. Piskin S., Sayan C., Durukan N., Senol M. Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis. - J Eur Acad Dermatol Venereol. - 2002; 16 (1): 66-7.
  61. Polan´ska B., Niemczuk M., Augustyniak D. et al. Plasma neutrophil elastase in children with recurrent aphthous stomatitis. - Centr Eur J Immunol. - 2006; 31: 15-17.
  62. Pradalier A., Dry J., Baron J.F. Aphthoid stomatitis induced by labetalol. - Therapie. - 1982; 37 (6): 695-7.
  63. Rajan B., Ahmed J., Shenoy N., Denny C., Ongole R., Binnal A. Assessment of quality of life in patients with chronic oral mucosal diseases: a questionnaire-based study. - Perm J. - 2014; 18 (1): 123-7
  64. Reichart P.A. Oral mucosal lesions in a representative cross-sectional study of aging Germans. - Community Dent Oral Epidemiol. - 2000; 28: 390-8.
  65. Riggio M.P., Lennon A., Wray D. Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR. - J Oral Pathol Med. - 2000; 29 (10): 507-13.
  66. Safadi R.A. Prevalence of recurrent aphthous ulceration in Jordanian dental patients. - BMC Oral Health. - 2009; 9: 31-36.
  67. Scully C. Porter S.R. Oral mucosal disease: Recurrent aphthous snomatitis. - British Journal of Oral and Maxillofacial Surgery. - 2008; 46: 198-206.
  68. Segal A.L., Katcher A.H., Brightman V.J., Miller M.F. Recurrent herpes labialis, recurrent aphthous ulcers, and the menstrual cycle. - J Dent Res. - 1974; 53 (4): 797-803.
  69. Shimoyama T., Horie N., Kato T., Kaneko T., Komiyama K. Helicobacter pylori in oral ulcerations. - J Oral Sci. - 2000; 42: 225-229.
  70. Ship I.I. Inheritance of aphthous ulcers of the mouth. - J Dent Res. - 1965; 44 (5): 837-44.
  71. Shohat-Zabarski R., Kalderon S., Klein T., Weinberger A. Close association of HLA-B51 in persons with recurrent aphthous stomatitis. - Oral Surg Oral Med Oral Pathol. - 1992; 74 (4): 455-8.
  72. Shulman J.D. Prevalence of oral mucosal lesions in children and youths in the USA. - Int J Paediatr Dent. - 2005; 15 (2): 89-97.
  73. Siegel M.A., Balciunas B.A. Medication can induce severe ulcerations. - J Am Dent Assoc. - 1991; 122 (9): 75-7.
  74. Sun A., Chu C.T., Wu Y.C., Yuan J.H. Mechanisms of depressed natural killer cell activity in recurrent aphthous ulcers. - Clin Immunol Immunopathol. - 1991; 60 (1): 83-92.
  75. Sun A., Hsieh R.P., Chu C.T., Wu Y.C. Strong association of HLA-DRw9 in Chinese patients with recurrent oral ulcers. - J Am Acad Dermatol. - 1991; 24 (2 Pt 1): 195-8.
  76. Taş D.A., Yakar T., Sakalli H., Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. - J Oral Pathol Med. - 2013; 42 (1): 89-94.
  77. Thomas H.C., Ferguson A., McLennan J.G., Mason D.K. Food antibodies in oral disease: a study of serum antibodies to food proteins in aphthous ulceration and other oral diseases. - J Clin Pathol. - 1973; 26 (5): 371-4.
  78. Victória J.M., Kalapothakis E., Silva Jde F., Gomez R.S. Helicobacter pylori DNA in recurrent aphthous stomatitis. - J Oral Pathol Med. - 2003; 32 (4): 219-23.
  79. Wilhelmsen N.S., Weber R., Monteiro F., Kalil J., Miziara I.D. Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the Brazilian population. - Braz J Otorhinolaryngol. - 2009; 75 (3): 426-31.
  80. Wray D., Graykowski E.A., Notkins A.L. Role of mucosal injury in initiating recurrent aphthous stomatitis. - Br Med J (Clin Res Ed). - 1981; 283 (6306): 1569-70.
  81. Wray D., Vlagopoulos T.P., Siraganian R.P. Food allergens and basophil histamine release in recurrent aphthous stomatitis. - Oral Surg Oral Med Oral Pathol. - 1982; 54 (4): 388-95.
  82. Zadik Y., Levin L., Shmuly T., Sandler V., Tarrasch R. Recurrent aphthous stomatitis: stress, trait anger and anxiety of patients. - J Calif Dent Assoc. - 2012; 40 (11): 879-83.

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Опубликовано

01.12.2015