DOI:

10.37988/1811-153X_2025_4_14

Comparative analysis of pharmacological and clinical efficacy of adhesive substances used in dental practice (a review)

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Authors

  • N.V. Lapina 1, Doctor of Science in Medicine, full professor of the Dentistry and prosthodontics Department
    ORCID: 0000-0003-1835-8898
  • D.V. Veselova 1, PhD in Pharmacy, associate professor and head of the Pharmacy Department, associate professor of the Disease prevention, Healthy lifestyle, and Epidemiology Department
    ORCID: 0000-0002-1199-7550
  • E.S. Ovcharenko 1, PhD in Medical Sciences, associate professor of the Dentistry Department
    ORCID: 0000-0002-0132-2517
  • M.V. Gordienko 1, assistant at the Pharmacy Department
    ORCID: 0000-0003-2404-0800
  • V.V. Lapin 1, 4th year student at the Dental Faculty, laboratory technician at the Surgical Dentistry and Maxillofacial surgery Department
    ORCID: 0009-0003-5768-6218
  • S.A. Knyshova 1, clinical resident of the Prosthetic dentistry Department
    ORCID: 0009-0001-0108-7537
  • D.A. Koblov 1, assistant at the Dentistry Department
    ORCID: 0009-0000-1452-6693
  • 1 Kuban State Medical University, 350063, Krasnodar, Russia

Abstract

In modern dental practice, adhesive pastes and films are used to treat inflammatory diseases of the periodontium and oral mucosa. They are made on the basis of adhesive pharmacological substances that differ in chemical composition, mechanism of action on the oral microbiome, mechanism of delivery of medicinal substances deep into the tissues, as well as temporary effect on tissues due to varying degrees of adhesion to the oral mucosa and periodontal tissues. The relevance of the problem lies in the need to develop modern domestic pharmacological substances that have the ability to create a barrier effect with prolonged release of drugs in periodontal diseases and oral mucosa, when there is a need to seal a mucosal defect (aphthae, erosion, ulcers) or close periodontal pockets to prevent the penetration of microflora and create obstacles to the effects of temperature, mechanical and chemical irritants and enhance the medicinal regenerative effect, as well as create the possibility of outflow of the exudative component from the wound surface, in traumatic and infectious-inflammatory processes on the oral mucosa. In practical dentistry, Solcoseryl dental adhesive paste was used for about 10 years, which disappeared from the sales market in the Russian Federation for more than 3—5 years. Domestic manufacturers are trying to produce analogs of this paste with different pharmacological effects. In this publication, based on the analysis of domestic and foreign sources, it is proposed to examine in detail the pharmacological composition and compare such drugs as Solcoseryl dental adhesive paste (Legacy Pharmaceuticals, Switzerland), Asepta adhesive balm for gums (Vertex, Russia), President Professional Adhesium adhesive balm for gums (President, Italy). And also to conduct a comparative analysis of adhesive pastes and films to determine the need to create new adhesive drugs in dentistry with more advanced and practically significant properties.

Key words:

adhesive pastes, adhesive films, periodontal diseases, pathology of the oral mucosa

For Citation

[1]
Lapina N.V., Veselova D.V., Ovcharenko E.S., Gordienko M.V., Lapin V.V., Knyshova S.A., Koblov D.A. Comparative analysis of pharmacological and clinical efficacy of adhesive substances used in dental practice (a review). Clinical Dentistry (Russia).  2025; 28 (4): 14—21. DOI: 10.37988/1811-153X_2025_4_14

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Received

July 28, 2025

Accepted

November 29, 2025

Published on

December 18, 2025