DOI:
10.37988/1811-153X_2025_4_62Overview of modern dental adhesive films for the treatment and prevention of periodontal diseases
Downloads
Abstract
The analysis of drug therapy and dental applications for the treatment and prevention of periodontal diseases, which are widespread in the pharmaceutical market, has been carried out. More than 80 domestic and foreign sources have been studied, selected by keywords: “periodontal diseases”, “periodontitis”, “gingivitis”, “dental films”, “dental anti-inflammatory drugs” with a selection of articles of the types clinical trial, meta-analysis, review, systematic review. After analyzing the scientific literature, an idea was obtained about the etiological factors and pathogenetic processes underlying inflammatory diseases of periodontal tissues. Modern methods of treatment of this group of diseases, in particular, drug therapy using application forms of medicines, are considered. A table of therapeutic and prophylactic films available on the pharmaceutical market is proposed, taking into account the main active ingredients widely used in dental practice.Conclusions.
When studying the studies, it was revealed that periodontal diseases are polyethological in nature and have many pathogenetic mechanisms of development, requiring careful study and requiring personalized treatment and prevention tactics depending on clinical manifestations. Dental films (plates), which contain both natural and synthetic components, are a promising tool at the initial stages of the development of inflammatory periodontal diseases. The expansion of the pharmaceutical market through the development of new formulations and film technologies will allow the doctor to choose the best treatment strategy for each patient, depending on the individual characteristics and clinical course of the disease.
Key words:
periodontitis, medical therapy of periodontitis, dental films, dental anti-inflammatory drugs, adhesive dosage formsFor Citation
[1]
Zaporozhskaya-Abramova E.S., Adamchik A.A., Shkurko I.V., Veselova D.V., Burlakova V.V. Overview of modern dental adhesive films for the treatment and prevention of periodontal diseases. Clinical Dentistry (Russia). 2025; 28 (4): 62—69. DOI: 10.37988/1811-153X_2025_4_62
References
- Celeste R.K., Oliveira S.C., Junges R. Threshold-effect of income on periodontitis and interactions with race/ethnicity and education. Rev Bras Epidemiol. 2019; 22: e190001. PMID: 30652730
- Oppermann R.V., Haas A.N., Rösing C.K., Susin C. Epidemiology of periodontal diseases in adults from Latin America. Periodontol 2000. 2015; 67 (1): 13—33. PMID: 25494596
- Schuch H.S., Peres K.G., Singh A., Peres M.A., Do L.G. Socioeconomic position during life and periodontitis in adulthood: a systematic review. Community Dent Oral Epidemiol. 2017; 45 (3): 201—208. PMID: 28032355
- Filgueiras L.V., Konflanz W., Haas A.N., Celeste R.K. Assessment of the contextual effects on the prevalence of periodontitis: a systematic review. Braz Oral Res. 2023; 36: e0125. PMID: 36651384
- Kopytov A.A., Leontiev V.K. Evolutionarily determined morphological changes that predetermine periodontal disease. Parodontologiya. 2022; 1: 13—19 (In Russian). eLIBRARY ID: 48074252
- Kopytov A.A., Leontyev V.K. Hydrodynamic disorders as an etiological factor of periodontitis and periodontal disease. Belgorod, 2022. Pp. 24—27 (In Russian). eLIBRARY ID: 49396991
- Yupatov E.Yu., Kurmanbaev T.E., Timoshkova Yu.L. Understanding endothelial function and dysfunction: state-of-the-art (a review). Russian Medical Journal. 2022; 3: 20—23 (In Russian). eLIBRARY ID: 48709096
- Nekrasova E.F., Garazha S.N., Khubaev Z.S., Grishilova E.N., Ivashova A.V., Gotlib A.O. Hemodynamic periodontal changes in the treatment of chronic generalized periodontitis using polarized polychromatic light. Russian Journal of Dentistry. 2024; 4: 358—364 (In Russian). eLIBRARY ID: 74990387
- Dubinin S., Zaitsev A., Vatsenko A., Ulanovskaya-Tsyba N., Perederii N., Boichenko O. Intermicrobial interactions of the oral biotope. Georgian Medical News. 2020; 2 (299): 131—137 (In Russian).
- Leonteva A.V., Pototskaya L.A., Chervinets Y.V. Mechanisms of oral microbial biofilm formation in healthy people and patients with chronic generalized periodontitis. Parodontologiya. 2023; 3: 208—217 (In Russian). eLIBRARY ID: 54673318
- Gimranova I.A., Gritsenko V.A., Rabinovich I.M., Akmalova G.M., Shvets D.Yu. The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology. Clinical Dentistry (Russia). 2025; 1: 179—185 (In Russian). eLIBRARY ID: 80557871
- Sterzenbach T., Helbig R., Hannig C., Hannig M. Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications. Clin Oral Investig. 2020; 24 (12): 4237—4260. PMID: 33111157
- Gedif Meseret A. Oral biofilm and its impact on oral health, psychological and social interaction. International Journal of Oral and Dental Health. 2021; 7: 127. DOI: 10.23937/2469-5734/1510127
- Porokhova A.A. The role of marker periodontal pathogens in the progression of periodontitis. Bulletin of the Northern State Medical University. 2023; 1 (49): 148—150 (In Russian).
- Kline K.A., Fälker S., Dahlberg S., Normark S., Henriques-Normark B. Bacterial adhesins in host-microbe interactions. Cell Host Microbe. 2009; 5 (6): 580—92. PMID: 19527885
- Vengadesan K., Narayana S.V. Structural biology of Gram-positive bacterial adhesins. Protein Sci. 2011; 20 (5): 759—72. PMID: 21404359
- van der Westen R., Sjollema J., Molenaar R., Sharma P.K., van der Mei H.C., Busscher H.J. Floating and tether-coupled adhesion of bacteria to hydrophobic and hydrophilic surfaces. Langmuir. 2018; 34 (17): 4937—4944. PMID: 29649869
- Teughels W., et al. Effect of material characteristics and/or surface topography on biofilm development. Clin Oral Implants Res. 2006; 17 Suppl 2: 68—81. PMID: 16968383
- Spengler C., Thewes N., Jung P., Bischoff M., Jacobs K. Determination of the nano-scaled contact area of staphylococcal cells. Nanoscale. 2017; 9 (28): 10084—10093. PMID: 28695218
- Hansmeier N., Miskiewicz K., Elpers L., Liss V., Hensel M., Sterzenbach T. Functional expression of the entire adhesiome of Salmonella enterica serotype Typhimurium. Sci Rep. 2017; 7 (1): 10326. PMID: 28871183
- Sjollema J., van der Mei H.C., Hall C.L., Peterson B.W., de Vries J., Song L., Jong E.D., Busscher H.J., Swartjes J.J.T.M. Detachment and successive re-attachment of multiple, reversibly-binding tethers result in irreversible bacterial adhesion to surfaces. Sci Rep. 2017; 7 (1): 4369. PMID: 28663565
- Arutyunov A.S., Tsareva T.V., Kirakosyan L.G., Levchenko I.M. Features and significance of adhesion of bacteria and fungi of the oral cavity as the initial stage of the formation of a microbial biofilm on dental polymer materials. Stomatology. 2020; 2: 79—84 (In Russian). eLIBRARY ID: 42851810
- Davidovich N.V., Galiyeva A.S., Kukalevskaya N.N., Bashilova E.N., Opravin A.S., Solovyova N.V. Endothelial dysfunction and periodontopathogenic microflora: Aspects of pathogenetic correction with bacteriophage. Eruditio Juvenium. 2023; 4: 465—473 (In Russian). eLIBRARY ID: 58733640
- Savkina A.A., Lengert E.V., Ermakov A.V., Smyshlaeva I.V., Popykhova E.B., Stepanova T.V., Lagutina D.D., Ivanov A.N. Morphological and microcirculator disorders of periodontal tissues in white rats with chronic generalized periodontitis. Modern Problems of Science and Education. 2021; 6: 133 (In Russian). eLIBRARY ID: 47670083
- Petrov A.A., Kosova E.V., Loboda E.S., Andreyev D.I., Vashneva V.Yu., Mordovina A.M., Orekhova L.Yu. Optimizing professional oral hygiene tactics with various methods and tools: impact on microcirculation in periodontal tissues. Parodontologiya. 2024; 3: 313—330 (In Russian). eLIBRARY ID: 73165651
- Orekhova L.Yu., Loboda E.S., Berezkina I.V., Boeva P.A., Rachina D.V. Comparative evaluation of clinical efficiency of different generations of air-polishing powders during professional oral hygiene. Pediatric Dentistry and Profilaxis. 2020; 4 (76): 296—302 (In Russian). eLIBRARY ID: 44583345
- Putova E.N., Sukhodolskaya V.A., Muzikin M.I., Iordanishvili A.K. Features of professional oral hygiene in school-age children. Children’s Medicine of the North-West. 2023; 1: 93—96 (In Russian). eLIBRARY ID: 50323829
- Gomon Yu.M., Kolbin A.S. Problems of assessing economic effectiveness of antimicrobial agents: an experience of the Russian Federation. Clinical Microbiology and Antimicrobial Chemotherapy. 2022; 1: 23—29 (In Russian). eLIBRARY ID: 48883307
- Kim S.H., Semenya D., Castagnolo D. Antimicrobial drugs bearing guanidine moieties: A review. Eur J Med Chem. 2021; 216: 113293. PMID: 33640673
- Barantsevich N.E., Ivanova L.V., Barantsevich E.P. Acinetobacter baumannii: Mechanisms of Antimicrobial Resistance. Antibiotics and Chemotherapy. 2024; 11—12: 93—100 (In Russian). eLIBRARY ID: 80642418
- Rosas N.C., Lithgow T. Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance. Trends Microbiol. 2022; 30 (6): 544—552. PMID: 34872824
- Nadar S., Khan T., Patching S.G., Omri A. Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance. Microorganisms. 2022; 10 (2): . PMID: 35208758
- Davydov B.N., Domenyuk D.A., Bykov I.M., Ivchenko L.G., Dmitrienko S.V. Modern possibilities of clinical-laboratory and x-ray research in pre-clinical diagnostics and prediction of the risk of development of periodontal in children with sugar diabetes of the first type. Part I. Parodontologiya. 2018; 3 (88): 4—11 (In Russian). eLIBRARY ID: 36409037
- Micu I.C., et al. A local desiccant antimicrobial agent as an alternative to adjunctive antibiotics in the treatment of periodontitis: A narrative review. Antibiotics (Basel). 2023; 12 (3): 456. PMID: 36978324
- Noskova V.D. Pharmaceutical films as a promising platform for use in medical practice and cosmetology. Chronos. 2022; 8 (70): 13—15 (In Russian). eLIBRARY ID: 49571166
- Tariq M., Iqbal Z., Ali J., Baboota S., Talegaonkar S., Ahmad Z., Sahni J.K. Treatment modalities and evaluation models for periodontitis. Int J Pharm Investig. 2012; 2 (3): 106—22. PMID: 23373002
- Chukhno A.S., Bankina A.N., Brilliantova E.Yu. Kinetics of gelatin swelling in aqueous solutions of azoles. Butlerov Communications. 2014; 5: 84—88 (In Russian).
- Yakubova O.S., Bekesheva A.A., Guseva D.A. Comparative characteristics of the properties of different origin gelatin. In: proceedings of “IV International Baltic Maritime Forum”. Kaliningrad, 2016. Pp. 1528—1537 (In Russian). eLIBRARY ID: 29248405
- Serebryakova I.A., Surkov Yu.I., Genina E.A. Development of the composition and structure of horizontally layered optical phantoms of human skin with varying degrees of melanin pigmentation. In: collection of articles “Interaction of microwave, terahertz and optical radiation with semiconductor micro- and nanostructures, metamaterials and bioobjects”. Saratov, 2022. Pp. 245—249 (In Russian). eLIBRARY ID: 48606510
- Karamyan A.S., Bannud G. Transbuccal films in veterinary medicine: a comparative study of the effect of dosage forms on clinical and biochemical parameters of blood. RUDN Journal of Agronomy and Animal Industries. 2024; 3: 530—537 (In Russian). eLIBRARY ID: 76987646
- Oleynik O.I., Kubyshkina K.P., Oleynik E.A. Optimization of the treatment and prevention of periodontal diseases by the use of therapeutic adhesive plates. Health and Education Millennium. 2018; 5: 84—87 (In Russian). eLIBRARY ID: 34964688
Downloads
Received
July 7, 2025
Accepted
November 6, 2025
Published on
December 18, 2025




