DOI:

10.37988/1811-153X_2025_2_88

Clinical efficacy of using a heterogeneous collagen-containing gel composition for rupture of the vascular-nerve bundle of varying degrees in the clinic of maxillofacial trauma. Part 1. Evaluation of restoration of pain and tactile sensitivity

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Authors

  • M.S. Malykh 1, maxillofacial surgeon
    ORCID: 0000-0003-3448-7243
  • V.V. Sadovskij 2, 3, PhD in Medical Sciences, director; associate professor of the Pain management in dentistry Department
    ORCID: 0000-0003-1793-7222
  • R.V. Mellin 1, PhD in Medical Sciences, head of the maxillofacial and plastic surgery ward
    ORCID: 0000-0002-1587-0581
  • P.V. Romanov 1, ultrasonographer
    ORCID: 0009-0009-3803-4808
  • E.S. Kutin 4, 2nd year student
    ORCID: 0009-0001-4238-1038
  • H.M.S. Darawsheh 4, PhD in Medical Sciences, assistant professor at the Operative surgery and topographic anatomy Department
    ORCID: 0000-0002-1899-1282
  • Yu.L. Vasil’ev 4, 5, Doctor of Science in Medicine, professor of the Operative surgery and topographic anatomy Department; senior researcher at the Antimicrobial Photodynamic Therapy Lab
    ORCID: 0000-0003-3541-6068
  • 1 Republican Clinical Hospital, 655012, Abakan, Russia
  • 2 “National Institute for Research and Adaptation of Marketing Strategies (NIIAMS)” JSC, 125047, Moscow, Russia
  • 3 Russian University of Medicine, 127006, Moscow, Russia
  • 4 Sechenov University, 119048, Moscow, Russia
  • 5 MIREA — Russian Technological University, 119454, Moscow, Russia

Abstract

There are many methods and medical tactics for solving the problems of nerve damage, in particular in the practice of a maxillofacial surgeon, one of which is the implantation of microparticles of a cross-linked collagen fraction. The aim of the study was to evaluate the clinical efficacy of using an extracellular matrix (ECM) biomimetic in the treatment of traumatic paresthesia after damage to the inferior alveolar nerve.
Materials and methods.
The study involved 16 patients undergoing treatment and rehabilitation for damage to the inferior alveolar nerve due to a fracture of the lower jaw, who were divided into 2 groups according to treatment tactics: traditional and introduction of a bioimplant according to the scheme of 1 ml on day 0, then 0.5 ml on days 7 and 15. All patients underwent measurement of electrical excitability of teeth near the fracture line and assessment of the area of hypo- and paresthesia.
Results.
The results we obtained on the change in the electrical excitability of the dental pulp against the background of the use of the extracellular matrix biomimetic in Group II by the 15th day up to the 86.4 μA mark indicate the restoration of threshold values corresponding to the physiological norm, and the restoration of sensitivity in almost the entire area of the lesion, which amounted to 91% of the total area (2.2 cm2).
Conclusions.
The restoration of pain and tactile sensitivity show the effectiveness of the proposed use of the biomimetic extracellular matrix composition of the heterogeneous collagen-containing gel “SPHERO®gel LIGHT” for damage to the inferior alveolar nerve in the clinic of maxillofacial trauma, regardless of the duration of the lesion according to the scheme: 1 ml of the drug, on the 7th and on the 15th day — 0.5 ml.

Key words:

bioimplant, heterogeneous collagen-containing gel compositions, maxillofacial trauma, paresthesia, electronic pulp test, SPHEROgel, jaw fracture

For Citation

[1]
Malykh M.S., Sadovskij V.V., Mellin R.V., Romanov P.V., Kutin E.S., Darawsheh H.M.S., Vasil’ev Yu.L. Clinical efficacy of using a heterogeneous collagen-containing gel composition for rupture of the vascular-nerve bundle of varying degrees in the clinic of maxillofacial trauma. Part 1. Evaluation of restoration of pain and tactile sensitivity. Clinical Dentistry (Russia).  2025; 28 (2): 88—94. DOI: 10.37988/1811-153X_2025_2_88

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Received

May 22, 2025

Accepted

June 14, 2025

Published on

July 5, 2025