DOI:

10.37988/1811-153X_2024_1_60

Clinical and radiological evaluation of the use of bone-plastic material based on collagen hydrogel in the experiment

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Authors

  • A.M. Sipkin 1, PhD in Medical Sciences, head of the Maxillofacial surgery and hospital surgical dentistry Department
    ORCID ID: 0000-0001-8287-741X
  • T.N. Modina 2, PhD in Medical sciences, full professor of the Dentistry Department
    ORCID ID: 0000-0002-2063-9464
  • N.D. Gnatyuk 1, postgraduate at the Maxillofacial surgery and hospital surgical dentistry Department
    ORCID ID: 0000-0001-5756-4999
  • D.U. Okshin 1, junior researcher at the Maxillofacial surgery Division
    ORCID ID: 0000-0002-1307-3968
  • E.O. Andriadze 1, researcher at the Maxillofacial surgery Division
    ORCID ID: 0000-0003-2824-2039
  • P.V. Solomatin 1, junior researcher at the X-Ray Division
    ORCID ID: 0000-0002-9292-8302
  • E.O. Osidak 3, PhD in Biology, production department employee
    ORCID ID: 0000-0003-2549-4011
  • 1 Moscow Regional Research Clinical Institute (MONIKI), 129110, Moscow, Russia
  • 2 REAVIZ Medical University, 107564, Moscow, Russia
  • 3 Imtek LLC, 121552, Moscow, Russia

Abstract

Bone grafting surgeries used to restore or increase jaw bone volume involve the use of osteoplastic materials of various forms and nature of origin. One of the new forms of such materials is xenogenic collagen hydrogel.
Materials and methods.
Collagen hydrogel in combination with xenogenic bone matrix was used as an implant to study the processes of bone tissue regeneration. An experimental study was carried out on 60 laboratory rats in which a critical defect of the skull vault was formed. The assessment of clinical signs in the early postoperative period was performed, as well as radiologic examination on the 30th, 60th and 90th days with calculation of the defect repair area and tissue density according to Hounsfield (HU). The migration of bone material beyond the defect was also recorded radiologically.
Results.
The wound defect was healed by primary tension without complications both in the early and in the late postoperative period. The bone defect in animals of the experimental group after 30 days was restored on the average by 44%, after 60 days — by 67% and by 89% after 90 days, while in animals of the comparison group after 1 month the defect was restored by 43%, after 2 months — by 62%, and after 3 months — by 84%. The average bone density of the regenerate in the experimental group after 30, 60 and 90 days was 846, 946 and 1220 HU, respectively, whereas in the comparison group during the same observation periods it was 819, 930 and 1007 HU, respectively.
Conclusion.
The use of collagen hydrogel in the composition of bone plastic material promotes the formation of a regenerate of higher density in the area of bone defect. Collagen hydrogel provides improvement of the manipulation properties of the material, forming a plastic mass capable of adapting to the defect shape and holding fine structures for a long time. The use of collagen hydrogel as a component of bone-plastic materials is promising, it requires further study.

Key words:

collagen hydrogel, bone grafting, bone plastic material, collagen

For Citation

[1]
Sipkin A.M., Modina T.N., Gnatyuk N.D., Okshin D.U., Andriadze E.O., Solomatin P.V., Osidak E.O. Clinical and radiological evaluation of the use of bone-plastic material based on collagen hydrogel in the experiment. Clinical Dentistry (Russia).  2024; 27 (1): 60—65. DOI: 10.37988/1811-153X_2024_1_60

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Received

October 3, 2023

Accepted

January 17, 2024

Published on

March 21, 2024