DOI:

10.37988/1811-153X_2023_3_115

Oral virome: the beginning of the path (review)

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Authors

  • I.P. Balmasova 1, PhD in Medical Sciences, professor, leading researcher of the Molecular biology research Laboratory
    ORCID ID: 0000-0001-8194-2419
  • V.N. Tsarev 1, PhD in Medical Sciences, full professor of the Microbiology, virology, immunology department, director of the Medico-dental research Institute
    ORCID ID: 0000-0002-3311-0367
  • R.S. Gvetadze 1, Russian Academy of Science corresponding member, PhD in Medical Sciences, professor of the Digital dentistry Department
    ORCID ID: 0000-0003-0508-7072
  • M.S. Mustafaev 2, PhD in Medical Sciences, professor, director of the Dentistry and maxillofacial surgery Institute
    ORCID ID: 0000-0002-4042-9421
  • T.V. Tsareva 1, PhD in Medical Sciences, associate professor of the Microbiology, virology, immunology Department
    ORCID ID: 0000-0001-9571-0520
  • E.S. Malova 3, PhD in Medical Sciences, professor of the Internal medicine Department
    ORCID ID: 0000-0001-5710-3076
  • D.S. Arutyunov 1, PhD in Medical Sciences, associate professor of the Propaedeutics and prosthodontics technology Department
    ORCID ID: 0009-0002-9325-2751
  • M.V. Timoshchenko 1, PhD in Medical Sciences, assistant professor of the Digital dentistry Department
    ORCID ID: 0000-0002-6949-9351
  • Ya.N. Kharakh 1, PhD in Medical Sciences, associate professor of the Digital dentistry Department
    ORCID ID: 0000-0001-7181-8211
  • S.D. Arutyunov 1, PhD in Medical Sciences, full professor of the Digital dentistry Department
    ORCID ID: 0000-0001-6512-8724
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia
  • 2 Kabardino-Balkarian State University, 360004, Nalchik, Russia
  • 3 Medical University “REAVIZ”, 443001, Samara, Russian Federation

Abstract

The human oral virome is a part of the microbiome as a community of microorganisms inhabiting the oral cavity, includes eukaryotic viruses that persist in the human body and microbial viruses (bacteriophages). Virome performs the most important physiological functions to protect the human body from pathogens through the control of the microbiome composition, the impact on the formation of biofilms, immunomodulatory effects, plays a huge role in the human evolution as a whole, but often serves as a source of serious diseases. Among the eukaryotic viruses inhabiting the oral cavity, the leading role in the development of pathological conditions of this localization, in particular, periodontal diseases, belongs to herpesviruses (Epstein—Barr virus, cytomegalovirus), the etiopathogenetic significance of which is only partially deciphered and it remains to be clarified. In the fight against diseases of the oral cavity, the use of bacteriophages is promising, although the conditions and variants for their use need further study.

Key words:

virome, microbiome, eukaryotic viruses, bacteriophages, herpesviruses

For Citation

[1]
Balmasova I.P., Tsarev V.N., Gvetadze R.S., Mustafaev M.S., Tsareva T.V., Malova E.S., Arutyunov D.S., Timoshchenko M.V., Kharakh Ya.N., Arutyunov S.D. Oral virome: the beginning of the path (review). Clinical Dentistry (Russia).  2023; 26 (3): 115—124. DOI: 10.37988/1811-153X_2023_3_115

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Received

June 18, 2023

Accepted

August 20, 2023

Published on

September 24, 2023