DOI:

10.37988/1811-153X_2023_1_84

Clinical and immunological effectiveness of non-surgical treatment of chronic periodontitis

Downloads

Authors

  • S.N. Gontarev 1, PhD in Medical Sciences, full professor of the Paediatric dentistry Department
    ORCID ID: 0000-0003-3472-6566
  • I.S. Gontareva 1, PhD in Medical Sciences, associate professor of the General dentistry Department, associate professor of the Paediatric dentistry Department
    ORCID ID: 0000-0002-4517-7032
  • A.V. Cymbalistov 1, PhD in Medical Sciences, full professor of the Prosthodontics Department, professor of the of General dentistry Department
    ORCID ID: 0000-0002-4474-7611
  • D.S. Punko 2, dentist
  • 1 Belgorod State University, 308015, Belgorod, Russia
  • 2 United Dental Polyclinic of Stary Oskol City District, 309516, Stary Oskol, Russia

Abstract

Chronic periodontitis is a common infectious and inflammatory disease that leads to serious financial costs for treatment by patients and the state, dysfunction of the dental system and tooth loss. Therefore, increasing the effectiveness of conservative therapy of chronic periodontitis does not lose relevance at the present time. The aim was to analysis of clinical and immunological effectiveness of non-surgical treatment of chronic periodontitis. >. Two groups of patients with chronic periodontitis were formed in clinical conditions — the main (n=52) and control (n=43), distinguished by conservative therapy. Patients of the main group, in addition to standard therapy, received topically 2.0% chlorhexidine gel 4 times a day, exposure to a diode laser with a wavelength of 810 nm and a power of 0.5 W for 2 minutes every other day on the affected area and a drug with sulfadiazine (400 mg) and trimethoprim (80 mg) 1 tablet 2 times a day during time to eat for 11 days. The interleukin status of gingival fluid was studied by enzyme immunoassay and clinical indices according to the generally accepted method. >. The optimized therapy contributed to the improvement of dental indices and especially the hygiene index of the approximal surfaces of teeth from 80.2 to 34.7% after 12 days and up to 27.9% after 3 months (p<0.001) against 76.2, 49.1 and 38.9% in the control, PMA index from 52.4 to 21.9 and 15.4% against 50.9, 31.6 and 24.1% in control. Among local interleukins, the level of IL-4 decreased most significantly and significantly from 30.3 to 20.8 and to 4.1 pg/ml in the main group versus 34.2, 28.5 and 12.7 pg/ml in the control group. The concentration of IL-1β, IL-6, IL-8, and IL-17 also decreased (p<0.01) in both groups, but more significantly against the background of the three-component therapy proposed by us. >. The developed non-surgical therapy of chronic periodontitis shows high clinical and immunological effectiveness.

Key words:

chronic periodontitis, conservative therapy, diode laser, chlorhexidine gel, sulfonamide preparation, interleukins, dental indices, non-surgical treatment

For Citation

[1]
Gontarev S.N., Gontareva I.S., Cymbalistov A.V., Punko D.S. Clinical and immunological effectiveness of non-surgical treatment of chronic periodontitis. Clinical Dentistry (Russia).  2023; 26 (1): 84—90. DOI: 10.37988/1811-153X_2023_1_84

References

  1. Puzin S.N., Pryanikov I.V., Vanchenko N.B., Karakov K.G., Shurgaya M.A. Medical and social aspects of chronic general parodontitis. Medical and Social Expert Evaluation and Rehabilitation. 2018; 3—4: 129—133 (In Russ.). eLIBRARY ID: 37188622
  2. Fischer R.G., Lira-Junior R., Retamal-Valdes B., Figueiredo L.C., Malheiros Z., Stewart B., Feres M. Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis. Braz Oral Res. 2020; 34 (supp1 1): e026. PMID: 32294679
  3. Trovik T.A., Klock K.S., Haugejorden O. Trends in reasons for tooth extractions in Norway from 1968 to 1998. Acta Odontol Scand. 2000; 58 (2): 89—96. PMID: 10894431
  4. Listl S., Galloway J., Mossey P.A., Marcenes W. Global economic impact of dental diseases. J Dent Res. 2015; 94 (10): 1355—61. PMID: 26318590
  5. Gontarev S.N., Gontareva I.S., Yasin M., Kobzeva G.B. Ways to achieve positive dynamics in the management of patients with a chronic generalized periodontitis of mild severity. Clinical Dentistry (Russia). 2022; 2: 38—44 (In Russ.). eLIBRARY ID: 48679073
  6. Tsarev V.N., Yagodina E.A., Tsareva T.V., Nikolaeva E.N. The impact of the viral-bacterial consortium on occurrence and development of chronic periodontitis. Parodontologiya. 2020; 2: 84—89 (In Russ.). eLIBRARY ID: 42820275
  7. Aslroosta H., Yaghobee S., Akbari S., Kanounisabet N. The effects of topical erythropoietin on non-surgical treatment of periodontitis: a preliminary study. BMC Oral Health. 2021; 21 (1): 240. PMID: 33957902
  8. Gribovskaya I.A., Solodilova M.A., Mal G.S. The efficacy of Rosuvastatin in elderly patients with coronary heart disease on the background of acute respiratory viral infection with various polymorphic variants of interleukin genes. Research Results in Biomedicine. 2021; 4: 410—420 (In Russ.). eLIBRARY ID: 47565158
  9. Yanushevich O.O., Kuzmina E.M., Maksimovsky Y.M., Maly A.Yu., Dmitrieva L.A., Revazova Z.E, Pochtarenko V.A., Ektova A.I., Wagner V.D., Grudyanov A.I., Smirnova L.E. Clinical recommendations (treatment protocols) for the diagnosis of periodontitis. Moscow: Moscow State University of Medicine and Dentistry, 2018. 116 p. (In Russ.).
  10. Agarkov N.M., Glagoleva Ya.V., Zamulin D.O., Gontareva S.N. Dynamics of humoral immunity in gingival fluid during combined immunotherapy in pediatric patients with exacerbation of chronic granulomatous periodontitis. Medical Immunology (Russia). 2020; 3: 557—562 (In Russ.). eLIBRARY ID: 42847914
  11. Grudyanov A.I., Ovchinnikova I.I., Dmitrieva N.A. Antimicrobial and anti-inflammatory therapy in periodontology. Moscow: Medical Information Agency, 2004. Pp. 24—39 (In Russ.).
  12. Ivanova N.N., Koroleva I.V., Mikhailova E.S. Effectiveness of antibacterial therapy in patients with chronic generalised periodontitis clinical and microbiological evaluation. Eurasian Scientific Association. 2019; 5—3 (51): 178—181 (In Russ.). eLIBRARY ID: 38225105
  13. Bobkova I., Zinovenko O. Choice of low-Intensity laser radiation parameters for use in complex therapy of chronic generalized periodontitis. Dentistry. Aesthetics. Innovations. 2021; 3: 288—293 (In Russ.). eLIBRARY ID: 47131552
  14. Kharkar V.V., Kolte A.P., Kolte R.A., Bawankar P.V., Lathiya V.N., Bodhare G.H. Influence of adjunctive photodynamic therapy on interleukin-6, interleukin-8, and interleukin-10 gingival crevicular fluid levels in chronic periodontitis A randomized controlled trial. Contemp Clin Dent. 2021; 12 (3): 235—240. PMID: 34759679

Downloads

Received

December 16, 2022

Accepted

February 13, 2023

Published on

March 22, 2023