DOI:

10.37988/1811-153X_2023_1_68

Assessment of microhemodynamics in periodontal tissues during treatment of chronic generalized periodontitis with photodynamic therapy

Downloads

Authors

  • F.F. Losev 1, PhD in Medical Sciences, full professor, director
    ORCID ID: 0000-0002-9448-9614
  • E.K. Krechina 1, PhD in Medical Sciences, full professor of the Functional diagnostics Department
    ORCID ID: 0000-0003-2936-0707
  • E.V. Ivanova 2, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0002-6330-6942
  • E.Yu. Kuksa 1, PhD candidate at the Functional diagnostics Department
    ORCID ID: 0000-0001-7628-8678
  • 1 Central Research Institute of Dental and Maxillofacial Surgery, 119021, Moscow, Russia
  • 2 Russian Medical Academy of Continuous Professional Education, 125993, Moscow, Russia

Abstract

The aim of the work was to study the effectiveness of photodynamic therapy (PDT) according to the data of microhemodynamics and oxygen metabolism in periodontal tissues during the treatment of moderate chronic generalized periodontitis (CGP). >. Clinical and functional examination and treatment of moderate CGP were carried out in 60 people (24 men and 36 women) aged 35 to 50 years (42.5±2.7 years) without somatic pathology and with orthognathic bite. The patients were divided into 2 equal groups according to the type of treatment: I (main), whose patients received PDT with 1% Geleofor gel (660 nm, 2.5 W/cm2, 8 min, 4 sessions) after oral hygiene, plaque removal, selective grinding of teeth, curettage of periodontal pockets and training in rational hygiene; II (control), whose patients received standard treatment. The hemodynamics in the periodontal tissues with determination of systolic, average and diastolic blood flow, systolic and average volumetric blood flow, pulsatility index and peripheral blood flow resistance index were studied by ultrasonic dopplerography (USDG). Oxygenation in the periodontal tissues was also studied by optical tissue oximetry with measurement of oxygenation index, specific oxygen consumption and perfusion oxygen saturation index. All measurements were made before and after treatment as well as after 6 and 12 months. >. According to USDG data, linear and volumetric blood flow velocities increased by 50—200% after treatment, which indicated normalization of microhemodynamics, which remained after 6 and 12 months in group I. In group I after PDT, the levels of perfusion saturation and specific oxygen consumption increased by 30 and 19%, respectively, and did not fall within 6 and 12 months. In group II after treatment, microhemodynamics increased less significantly — by 30—70%, the achieved indices were maintained up to 6 months, and in 12 months they decreased to their baseline levels. Improvement of oxygen metabolism was less significant — by 10—38%, and the parameters restored to their baseline values in 6 and 12 months. >. The application of PDT with 1% gel Geleofor activates microhemodynamics and oxygen metabolism processes.

Key words:

periodontitis, microhemodynamics, oxygenation, LED radiation, PDT

For Citation

[1]
Losev F.F., Krechina E.K., Ivanova E.V., Kuksa E.Yu. Assessment of microhemodynamics in periodontal tissues during treatment of chronic generalized periodontitis with photodynamic therapy. Clinical Dentistry (Russia).  2023; 26 (1): 68—72. DOI: 10.37988/1811-153X_2023_1_68

References

  1. Grudyanov A.I., Fomenko E.V. Methods of conservative treatment of inflammatory periodontal diseases. Moscow, 2013. 87 p. (In Russ.).
  2. Grudyanov A.I., Fomenko E.V., Kalyuzhin O.V. The role of NOD-like receptors of innate immune cells in the pathogenesis of chronic periodontitis. Literature review. International Dental Review. 2021; 1 (94): 34—39 (In Russ.). eLIBRARY ID: 44910896
  3. Grudyanov A.I. Issues of diagnosis and classification of periodontal diseases. Moscow: Medical Information Agency, 2021. 164 p. (In Russ.).
  4. Dmitrieva L.A., Maksimovsky Y.M. Therapeutic dentistry: national guidelines. Moscow: GEOTAR-Media, 2015. 881 p. (In Russ.).
  5. Garcia V.G., Longo M., Fernandes L.A., Gualberto E.C. Jr, Santinoni Cdos S., Bosco A.F., Nagata M.J., Theodoro L.H. Treatment of experimental periodontitis in rats using repeated adjunctive antimicrobial photodynamic therapy. Lasers Med Sci. 2013; 28 (1): 143—50. PMID: 22526974
  6. Gadzatseva Z.M. Improving the effectiveness of complex treatment of chronic generalized periodontitis through the use of laser photodynamic system “HELBO”: master's thesis. Stavropol, 2010. 22 p. (In Russ.).
  7. Yagudaev D.M., Sorokaty A.E., Geinits A.V., Trukhmanov R.S. Current views on the mechanism of photodynamic therapy. Urologiia. 2006; 5: 94—98 (In Russ.). eLIBRARY ID: 9252830
  8. Ahad A., Lamba A.K., Faraz F., Tandon S., Chawla K., Yadav N. Effect of Antimicrobial Photodynamic Therapy as an Adjunct to Nonsurgical Treatment of Deep Periodontal Pockets: A Clinical Study. J Lasers Med Sci. 2016; 7 (4): 220—226. PMID: 28491256
  9. Akram Z., Abduljabbar T., Sauro S., Daood U. Effect of photodynamic therapy and laser alone as adjunct to scaling and root planing on gingival crevicular fluid inflammatory proteins in periodontal disease: A systematic review. Photodiagnosis Photodyn Ther. 2016; 16: 142—153. PMID: 27619532
  10. Cappuyns I., Cionca N., Wick P., Giannopoulou C., Mombelli A. Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial. Lasers Med Sci. 2012; 27 (5): 979—86. PMID: 22105837
  11. Goh E.X., Tan K.S., Chan Y.H., Lim L.P. Effects of root debridement and adjunctive photodynamic therapy in residual pockets of patients on supportive periodontal therapy: A randomized split-mouth trial. Photodiagnosis Photodyn Ther. 2017; 18: 342—348. PMID: 28366818
  12. Stranadko E.F., Kuleshov I.Yu., Karakhanov G.I. Photodynamic effects on pathogenic microorganisms (Modern state-of-art in antimicrobial photodynamic therapy). Laser Medicine. 2010; 2: 52—56 (In Russ.). eLIBRARY ID: 14866925
  13. Biel M.A. Photodynamic therapy of bacterial and fungal biofilm infections. Methods Mol Biol. 2010; 635: 175—94. PMID: 20552348
  14. Demina K.Y., Grishilova E.N., Brazhnikova A.N., Garazha S.N., Batchaeva D.D., Gotlib A.O., Garazha N.N., Khachaturov S.S. Influence photodynamic therapy on hemodynamics in periodontal tissues in chronic generalized periodontitis. Fundamental research. 2014; 10—6: 1094—1097 (In Russ.). eLIBRARY ID: 22633954
  15. Yefremova N.V., Krechina E.K., Volkov A.V. The effectiveness of PDT in the correction of inflammatory changes in periodontal tissues according to the experimental studies. Endodontics Today. 2016; 2: 8—10 (In Russ.). eLIBRARY ID: 27187960
  16. Popova A.E. Optimization of methods of photodynamic therapy in the complex treatment of chronic generalized periodontitis of moderate severity: master's thesis. Moscow, 2014. 27 p. (In Russ.).
  17. Eremenko A.V., Karakov K.G., Khachaturyan E.E., Shatskaya N.V., Kasimova G.V., Vanchenko N.B. The results of a comprehensive periodontal therapy using the device “Vector” and antimicrobial photodynamic laser system. Modern Problems of Science and Education. 2016; 5: 147 (In Russ.). eLIBRARY ID: 27181770
  18. Orekhova L.Yu., LOBODA E.S., Oboyeva M.L. Photodynamic therapy in complex treatment of inflammatory periodontal diseases. Parodontologiya. 2015; 1 (74): 44—49 (In Russ.). eLIBRARY ID: 23413723
  19. Tsepov L.M., Nakonechnyi D.A., Goleva N.A., Nesterova M.M., Koifman O.B. Photodynamic therapy in the treatment of periodontitis (clinical observation). The Dental Institute. 2011; 3 (52): 58—59 (In Russ.). eLIBRARY ID: 17350552
  20. Bürgermeister L., López F.R., Schulz W. Physical and mathematical modeling of antimicrobial photodynamic therapy. J Biomed Opt. 2014; 19 (7): 71411. PMID: 24849516
  21. Segarra-Vidal M., Guerra-Ojeda S., Vallés L.S., López-Roldán A., Mauricio M.D., Aldasoro M., Alpiste-Illueca F., Vila J.M. Effects of photodynamic therapy in periodontal treatment: A randomized, controlled clinical trial. J Clin Periodontol. 2017; 44 (9): 915—925. PMID: 28667678
  22. Chitsazi M.T., Shirmohammadi A., Pourabbas R., Abolfazli N., Farhoudi I., Daghigh Azar B., Farhadi F. Clinical and Microbiological Effects of Photodynamic Therapy Associated with Non-surgical Treatment in Aggressive Periodontitis. J Dent Res Dent Clin Dent Prospects. 2014; 8 (3): 153—9. PMID: 25346834

Downloads

Received

February 11, 2023

Accepted

February 15, 2023

Published on

March 22, 2023