DOI:

10.37988/1811-153X_2022_4_106

Osteoplastic properties of a new material based on hydroxyapatite

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Authors

  • G.A. Demyashkin 1, 2, PhD in Medical Sciences, head of the Histology and Immunohistochemistry Lab; head of the Department of Pathomorphology
    ORCID ID: 0000-0001-8447-2600
  • S.Yu. Ivanov 1, Russian Academy of Science corresponding member, PhD in Medical Sciences, full professor of the Maxillofacial surgery Department
    ORCID ID: 0000-0001-5458-0192
  • A.A. Chueva 3, postgraduate at the Surgical Dentistry Department
    ORCID ID: 0000-0001-6625-8432
  • V.V. Chuev 3, PhD in Medical Sciences, associate professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0001-6625-8432
  • F.N. Bondarenko 2, postgraduate at the Department of Pathomorphology
    ORCID ID: 0000-0001-8952-4174
  • S.A. Suvorova 1, 5th year student
    ORCID ID: 0000-0002-7781-2723
  • 1 Sechenov University, 119991, Moscow, Russia
  • 2 Tsyb Medical Radiological Research Centre, 249031, Obninsk, Russia
  • 3 Belgorod State University, 308015, Belgorod, Russia

Abstract

Nowadays tissue engineering is actively developing in the world, which is aimed at the development and study of materials capable of restoring, maintaining or improving the natural tissues of the body. The greatest success in this area has been achieved in the bone tissue engineering, which is widely used in modern dentistry and maxillofacial surgery. In this study, the osteogenic, osteoinductive, osteoconductive and immunogenic properties of the new material Bioplast-Dent (VladMiVa, Russia) based on hydroxyapatite of biological origin were analyzed. >. In the Wistar rats (n=20), two bone defects 7 mm in diameter were created in the parietal bone, one of which was filled with paste, and the other was left open for control comparison. The results were evaluated using micro-computed tomography and histological examination of skull specimens. >. One month after implantation, the volume of tissue in the area of the experimental defect was 16.49±3.31 mm3 against 3.64±1.17 mm3 in the control defect, and on the 2nd month it was 18.24±4.14 mm3 against 3.82±0.83 mm3, respectively. Histological examination revealed signs of osteogenesis along the periphery of the implant material, no inflammation was detected. >. Bioplast-Dent is safe and effective for use in the reconstruction of bone defects: because of high biocompatibility and osteogenic properties.

Key words:

hydroxyapatite, implantation, bone defect, paste

For Citation

[1]
Demyashkin G.A., Ivanov S.Yu., Chueva A.A., Chuev V.V., Bondarenko F.N., Suvorova S.A. Osteoplastic properties of a new material based on hydroxyapatite. Clinical Dentistry (Russia).  2022; 25 (4): 106—113. DOI: 10.37988/1811-153X_2022_4_106

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Received

October 16, 2022

Accepted

November 8, 2022

Published on

December 21, 2022