DOI:

10.37988/1811-153X_2022_4_64

Peculiarities of selection of modern adhesive medications for treatment of inflammatory periodontal and oral mucosa diseases

Downloads

Authors

  • E.V. Velichko 1, PhD in Medical sciences, associate professor of the Dentistry diseases propaedeutics Department
    ORCID ID: 0000-0002-6196-0422
  • Yu.L. Vasil’ev 2, PhD in Medical Sciences, full professor of Operative surgery and topographic anatomy Department
    ORCID ID: 0000-0003-3541-6068
  • 1 RUDN University, 117198, Moscow, Russia
  • 2 Sechenov University, 119435, Moscow, Russia

Abstract

On the modern dental market, there is a wide range of adhesive pastes, gels and balms offered for the treatment of diseases of the oral mucosa and periodontium. It is very difficult to choose a suitable remedy, focusing on the trade names of drugs. For the analysis, articles were selected that have been published over the past ten years by Russian and world scientists. The main criteria for the selection of articles were those related to the active ingredients of drugs sold in the Russian Federation and produced in a gel form or in the form of an adhesive balm/paste used for application to the mucous membranes of the oral cavity and gums: Asepta balm for gums adhesive, Asepta gel for gums with propolis, Aftofix, Dentadez active, Dentamed, Donteks, Kamistad, Curasept periodontal gel with chlorhexidine 0.5%, Metrogil Denta, Parodium, Solcoseryl dental adhesive paste, Stomadent ZD, Holisal and Elugel. Based on the properties of the main active substances (anesthetic, non-steroidal anti-inflammatory drug, antiseptic, antibacterial drug), an analysis of their clinical effectiveness was carried out. >. Given the sensitivity of microorganisms of the oral cavity and periodontal pockets, as well as the lack of resistance to the active components of adhesive gels and pastes; the absence of the effect of inactivation of antibiotics and a decrease in the sensitivity of microflora to them; the ability to suppress the activity of the inflammatory process and pain; the possibility of use in environments with sharp shifts in pH, safety and non-toxicity, in case of any violations of the integrity of the mucous membranes (inflammation, neoplastic processes, trauma, radiation, etc.) and periodontium, the drug of choice is the only representative of the combination of cetalkonium chloride and choline salicylate — Holisal gel. This gel should be included in the mandatory treatment protocol for patients with OM and periodontal diseases in order to quickly cope with pain, inflammatory symptoms of diseases and enhance antibacterial and antifungal effects.

Key words:

oral mucosa, periodontium, gels, Holisal, cetalkonium chloride, choline salicylate, benzalkonium chloride, metronidazole, chlorhexidine, resistance

For Citation

[1]
Velichko E.V., Vasil’ev Yu.L. Peculiarities of selection of modern adhesive medications for treatment of inflammatory periodontal and oral mucosa diseases. Clinical Dentistry (Russia).  2022; 25 (4): 64—72. DOI: 10.37988/1811-153X_2022_4_64

References

  1. Moghadam E.T., Yazdanian M., et al. Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies. Eur J Pharmacol. 2020; 889: 173665. PMID: 33098834
  2. Austin A. Dental health and dentistry in ancient Egypt: Possible evidence for dental filling and extraction at Deir el-Medina. Int J Paleopathol. 2022; 38: 95—106. PMID: 35868059
  3. Jalali A., Kiafar M., Seddigh M., Zarshenas M.M. Punica granatum as a source of natural antioxidant and antimicrobial agent: A comprehensive review on related investigations. Curr Drug Discov Technol. 2021; 18 (2): 207—224. PMID: 32351184
  4. Karomatov I.D., Davlatova M.S. Juniper in traditional and scientific medicine. Biology and integrative medicine. 2018; 1 (18): 87—107 (In Russ.). eLIBRARY ID: 35285247
  5. Rakhmatova D.B. Pomegranate as a therapeutic agent in folk and ancient medicine. Biology and integrative medicine. 2022; 1 (54): 157—168 (In Russ.). eLIBRARY ID: 48159126
  6. Lyamin Y.S., Fedorova Yu.S., Kulpin P.V., Suslov N.I., Kucheryavyi D.V. Comparison between the efficacy plant and synthetic origin dental products in the treatment of chronic catarrhal gingivitis. Kazan Medical Journal. 2020; 1: 25—30 (In Russ.). eLIBRARY ID: 42343361
  7. Abasniya S.R. The identification of connection of parodontitis and diseases of vascular system. Modern Studies. 2018; 5 (09): 259—261 (In Russ.). eLIBRARY ID: 35155240
  8. Zhang S., Philips K.H., Moss K., Wu D., Adam H.S., Selvin E., Demmer R.T., Norby F.L., Mustapha I.Z., Beck J.D. Periodontitis and risk of diabetes in the Atherosclerosis Risk In Communities (ARIC) study: A BMI-modified association. J Clin Endocrinol Metab. 2021; 106 (9): e3546-e3558. PMID: 33982107
  9. Katola V.M., Komogortseva V.E. The role of oral microbiome in the development of inflammation and somatic pathology. Bulletin Physiology and Pathology of Respiration. 2018; 68: 117—122 (In Russ.). eLIBRARY ID: 35110819
  10. Kryukov A.I., Kunelskaya N.L., Gurov A.V., Izotova G.N., Starostina A.E., Lapchenko A.S. Clinical and microbiological characteristics of dysbiotic changes in the oral and oropharyngeal mucosa. Medical Council. 2016; 6: 32—35 (In Russ.). eLIBRARY ID: 26103968
  11. Lyubchenko O.V., Velihoria I.E., Pushkar L.Y., Poliakova S.V., Tzyganova N.B., Ivanov O.E., Sirota O.M. Preparations based on plant raw materials with antibacterial and fungicidal action in dentistry. SWorldJournal. 2022; 13—01: 103—109 (In Russ.). DOI: 10.30888/2663-5712.2022-13-01-054
  12. Navruzova U.O. Modern aspects of etiopatogenez of the generalized periodontal disease (review of literature). Biology and integrative medicine. 2019; 2 (30): 62—89 (In Russ.). eLIBRARY ID: 41474313
  13. Kesarwani S., Parihar S., Singh S., Gautam A., Pandey A., Anjum M.M. A new era of Nano!!! Comparative evaluation of ganglioside polymeric nanoparticle coated satranidazole gel and 1% metronidazole gel for the treatment of periodontitis. J Indian Soc Periodontol. 2022; 26 (4): 378—383. PMID: 35959308
  14. Karmatskaya N.V., Vasilevskaya E.S., Yachnikova M.A. Selection of drugs to the final consumers the main influence factors. Medical and pharmaceutical journal Pulse. 2019; 9: 73—78 (In Russ.). eLIBRARY ID: 39289618
  15. Lukichev M.M., Ermolaeva L.A. Modern ideas about the role of microflora in pathogenesis of periodontal disease. The Dental Institute. 2018; 1 (78): 92—94 (In Russ.). eLIBRARY ID: 34964799
  16. Hsaine S., Fethi F.Z., Charof R., Ounine K. Microbiological study of oral flora in diabetic patients with gingivitis. Int J Pharm Pharm Sci. 2018 May; 10 (6): 113—116.
  17. Stone S.J., Kumar P.S., Offenbacher S., Heasman P.A., McCracken G.I. Exploring a temporal relationship between biofilm microbiota and inflammatory mediators during resolution of naturally occurring gingivitis. J Periodontol. 2019; 90 (6): 627—636. PMID: 30565232
  18. Balmasova I.P., Lomakin Y.A., et al. «Shielding» of cytokine induction by the periodontal microbiome in patients with periodontitis associated with type 2 diabetes mellitus. Acta Naturae. 2019; 11 (4): 79—87. PMID: 31993238
  19. Ptasiewicz M., Grywalska E., Mertowska P., Korona-Głowniak I., Poniewierska-Baran A., Niedźwiedzka-Rystwej P., Chałas R. Armed to the teeth-the oral mucosa immunity system and microbiota. Int J Mol Sci. 2022; 23 (2): 882. PMID: 35055069
  20. Qurbonova N.I., Khabibova N.N. New possibilities of local antibacterial therapy and prevention of inflammatory periodontal diseases against the background of digestive organs pathology. Biology and iintegrative medicine. 2020; 3 (43): 64—74 (In Russ.). eLIBRARY ID: 43101056
  21. Semyonov D.Yu., Vasil‘ev Yu.L., Dydykin S.S., Stranadko E.F., Shubin V.K., Bogomazov Yu.K., Morokhotov V.A., Shcherbyuk A.N., Morozov S.V., Zakharov Yu.I. Antimicrobial and antimycotic photodynamic therapy (review of literature). Biomedical Photonics. 2021; 1: 25—31 (In Russ.). eLIBRARY ID: 45653006
  22. Peycheva S.K., Apostolova E.G., et al. Oral Microbial Flora in Bulgarian Adolescents with Moderate Plaque-induced Gingivitis. Folia Med (Plovdiv). 2019; 61 (4): 522—528. PMID: 32337880
  23. Tamrakar A.K., Murali G., Singh S., Shakila R. Evaluation of subgingival microbiota around single tooth implants. J Oral Biol Craniofac Res. 2020; 10 (2): 180—183. PMID: 32489818
  24. Tamarova E.R., Shvets K.Yu., Mavzyutov A.R., Baimiev Al.H., Bulgakova A.I. Creation of a molecular genetic test system for early diagnostics and evaluation of effectiveness of treatment of inflammatory periodontal diseases. Russian Clinical Laboratory Diagnostics. 2020; 1: 55—60 (In Russ.). eLIBRARY ID: 41800765
  25. Hassan S.A., Bhateja S., Arora G., Prathyusha F. Major antiseptic in dentistry. IP Journal of Surgery and Allied Sciences. 2020; 2 (2): 29—32. DOI: 10.18231/j.jsas.2020.001.
  26. Pałka Ł., Nowakowska-Toporowska A., Dalewski B. Is chlorhexidine in dentistry an ally or a foe? A narrative review. Healthcare (Basel). 2022; 10 (5): 764. PMID: 35627901
  27. Solderer A., Kaufmann M., Hofer D., Wiedemeier D., Attin T., Schmidlin P.R. Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review. Clin Oral Investig. 2019; 23 (1): 21—32. PMID: 30535817
  28. Brookes Z.L.S., Bescos R., Belfield L.A., Ali K., Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020; 103: 103497. PMID: 33075450
  29. Poppolo Deus F., Ouanounou A. Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects. Int Dent J. 2022; 72 (3): 269—277. PMID: 35287956
  30. Dounar H.G., Rzheuski S.E. Antimicrobial activity of the gel with chlorhexidine digluconate intended for the treatment of oral candidiasis. Vestnik of Vitebsk State Medical University. 2017; 3: 91—97 (In Russ.). eLIBRARY ID: 29325345
  31. Alpaslan Yayli N.Z., Tunc S.K., Degirmenci B.U., Dikilitas A., Taspinar M. Comparative evaluation of the cytotoxic effects of different oral antiseptics: A primary culture study. Niger J Clin Pract. 2021; 24 (3): 313—320. PMID: 33723103
  32. Druzhinina O.S., Kashapov N.F., Skorinkin A.I., Fayzullin D.A. The effect of chlorhexidine bigluconate on lipid bilayer structure. Bulletin of the Technological University . 2010; 9: 626—629 (In Russ.). eLIBRARY ID: 15286653
  33. Morozov D.I. Combined high-frequency ultrasound and antibacterial therapy in the complex treatment of periodontitis: master’s thesis. Moscow, 2021. P. 96. (In Russ.).
  34. Short F.L., Lee V., Mamun R., Malmberg R., Li L., Espinosa M.I., Venkatesan K., Paulsen I.T. Benzalkonium chloride antagonises aminoglycoside antibiotics and promotes evolution of resistance. EBioMedicine. 2021; 73: 103653. PMID: 34717227
  35. Jia Y., Lu H., Zhu L. Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds. Sci Total Environ. 2022; 832: 155090. PMID: 35398118
  36. DeSesso J.M., Harris S.B., Scialli A.R., Williams A.L. Systematic assessment of quaternary ammonium compounds for the potential to elicit developmental and reproductive effects. Birth Defects Res. 2021; 113 (20): 1484—1511. PMID: 34687283
  37. Sun Y., Wang Y., Zhou J., Zhou Q., Dong S. Screening of concentration and antimicrobial effectiveness of antimicrobial preservative in betastatin besylate nasal spray. Biomed Res Int. 2020; 2020: 1315069. PMID: 33415139
  38. Lee H., Park K. Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration. Environ Anal Health Toxicol. 2019; 34 (3): e2019009. PMID: 31771318
  39. Kwon D., Kwon J.T., Lim Y.M., Shim I., Kim E., Lee D.H., Yoon B.I., Kim P., Kim H.M. Inhalation toxicity of benzalkonium chloride and triethylene glycol mixture in rats. Toxicol Appl Pharmacol. 2019; 378: 114609. PMID: 31173787
  40. Hadrup N., Frederiksen M., et al. Asthma-inducing potential of 28 substances in spray cleaning products-Assessed by quantitative structure activity relationship (QSAR) testing and literature review. J Appl Toxicol. 2022; 42 (1): 130—153. PMID: 34247391
  41. Koutsoviti M., Siamidi A., Pavlou P., Vlachou M. Recent advances in the excipients used for modified ocular drug delivery. Materials (Basel). 2021; 14 (15): 4290. PMID: 34361483
  42. Daull P., Guenin S., Hamon de Almeida V., Garrigue J.S. Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles. Mol Vis. 2018; 24: 459—470. PMID: 30078983
  43. Daull P., Raymond E., Feraille L., Garrigue J.S. Safety and tolerability of overdosed artificial tears by abraded rabbit corneas. J Ocul Pharmacol Ther. 2018; 34 (10): 670—676. PMID: 30312113
  44. Labetoulle M., Benitez-Del-Castillo J.M., Barabino S., Herrero Vanrell R., Daull P., Garrigue J.S., Rolando M. Artificial tears: biological role of their ingredients in the management of dry eye disease. Int J Mol Sci. 2022; 23 (5): 2434. PMID: 35269576
  45. Yudina N., Iakovleva-Malykh M., Kostiuk S. Systemic administration of antibacterial drugs in the treatment of periodontal diseases, patterns and resistance of bacteria. Sovremennaya stomatologiya (Belarus). 2019; 1 (74): 55—59 (In Russ.). eLIBRARY ID: 37252996
  46. Elovicova T., Gaysina E., Prihodkin A. Use of antibacterial drugs for the treatment of aggressive periodontitis. Actual Problems in Dentistry. 2019; 1: 10—15 (In Russ.). eLIBRARY ID: 37602573
  47. Alauzet C., Lozniewski A., Marchandin H. Metronidazole resistance and nim genes in anaerobes: A review. Anaerobe. 2019; 55: 40—53. PMID: 30316817
  48. Maksimova O.P. The role of the drug “Cholisal” in complex treatment of periodontal disease and oral mucosa. Clinical Dentistry (Russia). 2018; 2 (86): 46—49 (In Russ.). eLIBRARY ID: 35154629
  49. Kirtaeva A.V. Study of histamine contents in the structure of gingiva under the conditions of the alcoholic intoxication. Ural Medical Journal. 2018; 7 (162): 26—29 (In Russ.). eLIBRARY ID: 36367340
  50. Wróblewska K.B., Plewa S., Dereziński P., Muszalska-Kolos I. Choline salicylate analysis: Chemical stability and degradation product identification. Molecules. 2019; 25 (1): E51. PMID: 31877863
  51. Said O.B., Razumova S., Velichko E., Tikhonova S., Barakat H. Evaluation of the changes of salivary pH among dental students depending on their anxiety level. Eur J Dent. 2020; 14 (4): 605—612. PMID: 32688407
  52. Mkhoyan G., Velichko E., Bait Said O., Serebrov D. Academic stress in oral diseases of students. Journal of International Dental & Medical Research. 2021; 14 (2): 790—796.
  53. Abeykoon J.P., Wu X., et al. Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. Blood. 2021; 137 (4): 513—523. PMID: 33507295
  54. Krauchanka R.V., Rzheuski S.E. Dental soft medicines market analysis. Bulletin of Pharmacy of Belarus. 2020; 1 (87): 37—42 (In Russ.). eLIBRARY ID: 42625750
  55. Baybekov I.M., Rakhmanov Kh.Sh., Irkhanov M.M. Antimicrobial and anti-inflammatory effects of laser irradiation and Cholisal in the treatment of prosthetic stomatitis. Laser Medicine. 2020; 2—3: 29—36 (In Russ.). eLIBRARY ID: 44628834

Downloads

Received

November 7, 2022

Accepted

November 15, 2022

Published on

December 21, 2022