DOI:

10.37988/1811-153X_2021_4_18

Methods of crystallography of oral fluid (a review)

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Authors

  • L.A. Simonyan 1, assistant at the Therapeutic dentistry Department
    ORCID ID: 0000-0002-0265-1988
  • L.M. Lomiashvili 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department, dean of the Dentistry Faculty
    ORCID ID: 0000-0003-1678-4658
  • I.V. Anisimova 1, PhD in Medical Sciences, assistant professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0003-0251-5545
  • O.I. Marshalok 1, PhD in Medical Sciences, assistant professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0001-7643-1139
  • 1 Omsk State Medical University, 644099, Omsk, Russia

Abstract

Oral fluid is a multicomponent and multifunctional biological material of the human body. Many researchers believe that saliva can serve as an indicator of physiological and pathological processes in the body of an individual. The section of medicine devoted to the study of saliva is known in the scientific literature as saliva diagnostics. The main advantages of this type of diagnostics are non-invasiveness and lack of emotional stress in the patient. However, saliva diagnostics, along with advantages, has certain disadvantages, which consist in the lack of standardization of the collection of biomaterials, generally accepted diagnostic methods and interpretation of the results obtained. Despite the disadvantages, saliva diagnostics is widely used to study in chemical composition and physical properties of saliva, the rate of salivation, as well as the microcrystalline pattern in a dried droplet of saliva (facies) using crystallography. A total of 53 scientific papers were reviewed for the period 1995—2021 (35 domestic and 18  foreign). Today there are crystalloscopic, tezigraphic and experimental crystalloscopic methods of crystallography. The crystalloscopic method of crystallography is based on obtaining the facies of a biological fluid by its crystallization. The tezigraphic method consists in initiated crystallogenesis, that is, the introduction of basic chemicals in order to activate crystallogenesis. Experimental crystalloscopic methods of crystallography combine all operations carried out with liquid biomaterial before and/or during dehydration to study the influence of external and internal factors on the result of drying out of biological fluid.
Conclusion.
Analysis of the literature shows that there is a sufficient variety of methods for crystallography of the oral fluid. Saliva diagnostics with the use of crystallography is a rapidly developing promising diagnostic direction in medicine, which makes it possible to identify pathological processes in the human body.

Key words:

oral fluid, saliva diagnostics, crystallography, microcrystallization

For Citation

[1]
Simonyan L.A., Lomiashvili L.M., Anisimova I.V., Marshalok O.I. Methods of crystallography of oral fluid (a review). Clinical Dentistry (Russia).  2021; 24 (4): 18—23. DOI: 10.37988/1811-153X_2021_4_18

References

  1. Zhang C.Z., Cheng X.Q., Li J.Y., Zhang P., Yi P., Xu X., Zhou X.D. Saliva in the diagnosis of diseases. Int J Oral Sci. 2016; 8 (3): 133—7. PMID: 27585820
  2. Vadzyuk S.N., Boliuk Yu.V., Luchynskyi M.A., Sluchyk V.M., Zukow W. Crystallographic features of oral fluid in young people with gingivitis. Journal of education, health and sport. 2020; 10 (9): 172—82. DOI: 10.12775/JEHS.2020.10.09.019
  3. Mikaelyan N.P., Komarov O.S., Davydov V.V., Meisner I.S. Biochemistry of oral fluid in health and disease. Moscow: IKAR, 2017. Pp. 7—10 (In Russ.).
  4. Likhorad E.V., Shakovets N.V. Saliva: the significance for the organs and tissues in the oral cavity in health and disease. Medical Journal. 2013; 3: 7—11 (In Russ.). eLIBRARY ID: 21038486
  5. Punj A. Secretions of human salivary gland. In: Salivary glands new approaches in diagnostics and treatment. 2018. DOI: 10.5772/intechopen.75538
  6. Anisimova I.V., Nedoseko V.B., Okhlopkov V.A., Nagaeva M.O. Clinic, diagnostics and treatment of diseases of the mucosa of the oral and lips. Omsk: Omsk State Medical Academy, 2015. Pp. 11—2 (In Russ.). eLIBRARY ID: 36330734
  7. Pedersen A., Sørensen C.E., Proctor G.B., Carpenter G.H. Salivary functions in mastication, taste and textural perception, swallowing and initial digestion. Oral Dis. 2018; 24 (8): 1399—1416. PMID: 29645367
  8. Borovskiy E.V., Leontiev V.K. Biology of the oral cavity. N. Novgorod: Nizhny Novgorod State Medical Academy, 2001. P. 172—86 (In Russ.).
  9. Farooq I., Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a narrative review. F1000Res. 2020; 9: 171. PMID: 32201577
  10. Pappa E., Vougas K., Zoidakis J., Papaioannou W., Rahiotis C., Vastardis H. Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes. Proteomes. 2021; 9 (3): 33. PMID: 34287355
  11. Kumar B., Kashyap N., Avinash A., Chevvuri R., Sagar M.K., Shrikant K. The composition, function and role of saliva in maintaining oral health: A review. International Journal of Contemporary Dental and Medical Reviews. 2017; 2017: 1—6.
  12. Maddu N. Functions of saliva. In: Saliva and salivary diagnostics. 2019. DOI: 10.5772/intechopen.84709
  13. Vila T., Rizk A.M., Sultan A.S., Jabra-Rizk M.A. The power of saliva: Antimicrobial and beyond. PLoS Pathog. 2019; 15 (11): e1008058. PMID: 31725797
  14. Pathiyil V., Udayasankar R. Salivary diagnostics. In: Saliva and salivary diagnostics. 2019. DOI: 10.5772/intechopen.84722
  15. Bellagambi F.G., Lomonaco T., Salvo P., Vivaldi F., Hangouet M., Ghimenti S., Biagini D., Francesco F., Fuoco R., Errachid A. Saliva sampling: Methods and devices. An overview. Trends in Analytical Chemistry. 2020; 124: 115781. DOI: 10.1016/j.trac.2019.115781
  16. Denisov A.B. Crystal structures of saliva. 2. Morfological analysis in cases of crystal structures absence. Dental Forum. 2011; 4: 44—6 (In Russ.). eLIBRARY ID: 16516810
  17. Postnova M.V., Mulik Yu.A., Novochadov V.V., Mulik A.B., Nazarov N.O., Frolov D.M. Mouth fluid as an object of estimating functional condition of human body. Journal of Volgograd State University. Economics. 2011; 1 (18): 246—253 (In Russ.). eLIBRARY ID: 33664258
  18. Selifanova E.I., Ivanov S.Yu., Mkrtumyan A.M., Denisov A.B., Chachiashvili M.V. Crystallization of oral fluid components in patients with type 1 diabetes mellitus. Bulletin of Experimental Biology and Medicine. 2005; 1 (139): 22—4 (In Russ). eLIBRARY ID: 9135630
  19. Turlak I.V. The saliva the main directions of research of its properties. Modern Problems of Science and Education. 2020; 4: 154 (In Russ). eLIBRARY ID: 43925169
  20. Breshchenko E.E., Bykov I.M. Biochemistry of the oral cavity, oral and gingival fluids. Krasnodar, 2018. Pp. 40—42 (In Russ.).
  21. Martusevich A.K., Kovaleva L.K., Kozlova L.M., Tuzhilkin A.N., Fedotova A.S., Krasnova S.Yu. Estimation of human saliva structurization at dehydration on the solid substrate. Clinical Dentistry (Russia). 2020; 3 (95): 4—9 (In Russ.). eLIBRARY ID: 44008059
  22. Ilea A., Andrei V., Feurdean C.N. et al. Saliva, a magic biofluid available for multilevel assessment and a mirror of general health—A systematic review. Biosensors (Basel). 2019; 9 (1): E27. PMID: 30769890
  23. Chatterjee S. Saliva as a forensic tool. J Forensic Dent Sci. 2019; 11 (1): 1—4. PMID: 31680748
  24. Vavilova T.P. Biochemistry of tissues and fluids of the oral cavity. Moscow, 2011. P. 169—73 (In Russ.).
  25. Vavilova T.P. Analytical capabilities and perspectives. Moscow: BINOM, 2014. P. 37 (In Russ.).
  26. Korot’ko G.F. The saliva diagnostics renaissance of non-invasive technologies. Kuban Scientific Medical Bulletin. 2006; 9: 145—49 (In Russ.). eLIBRARY ID: 9286903
  27. Chojnowska S., Baran T., Wilińska I., Sienicka P., Cabaj-Wiater I., Knaś M. Human saliva as a diagnostic material. Adv Med Sci. 2018; 63 (1): 185—91. PMID: 29149764
  28. Sri Santosh T., Parmar R., Anand H., Srikanth K., Saritha M. A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Cureus. 2020; 12 (4): e7708. PMID: 32313785
  29. Jasim H., Carlsson A., Hedenberg-Magnusson B., Ghafouri B., Ernberg M. Saliva as a medium to detect and measure biomarkers related to pain. Sci Rep. 2018; 8 (1): 3220. PMID: 29459715
  30. Prudnikova Z.P., Kamakin N.F. Saliva diagnostics using the elements of crystallography as one of the new methods for assessing health in the structure of sanitary and hygienic monitoring. Science and Modernity. 2014; 28: 73—5 (In Russ.). eLIBRARY ID: 21351403
  31. Bhattarai K.R., Kim H.R., Chae H.J. Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors. Int J Med Sci. 2018; 15 (8): 823—31. PMID: 30008593
  32. Elovikova T.M., Grigoriev S.S. Sialology in therapeutic dentistry. Yekaterinburg: Circulation, 2018. P. 30—5 (In Russ.).
  33. Andiushkin A.I., Sapozhnikov S.P., Karpunina A.V. Crystallography of biological liquids (survey of literature). Bulletin of the Chuvash University. 2013; 3: 355—9 (In Russ.). eLIBRARY ID: 21115339
  34. Buzoverya M.E., Shcherbak Y.P., Shishpor I.V., Potekhina Y.P. Microstructural analysis of biological fluids. Technical Physics. 2012; 82 (7): 123—8 (In Russ.). eLIBRARY ID: 20325641
  35. Shatokhina S.N. Diagnostic value of crystalline structures of biological fluids in the clinic of internal diseases: dissertation abstract. Moscow, 1995: 40 p. (In Russ.).
  36. Maksimov S.A. Morphology of the solid phase of biological liquids as method of diagnostics in medicine. Bulletin of Siberian medicine. 2007; 6 (4): 80—5 (In Russ.). eLIBRARY ID: 20170170
  37. Martusevich A.K., Zhdanova O.B., Shubina O.I. Crystal proteomics in modern biology and medicine. Medical Newsletter of Vyatka. 2012; 2: 23—9 (In Russ.). eLIBRARY ID: 17853181
  38. Akimov N.P., Shatokhina S.N., Kanaev A.S. Analysis of synovial fluid isomorphones in assessing the effectiveness of total knee arthroplasty. Scientific research: from theory to practice. 2015; 1 (2): 109—12. eLIBRARY ID: 24916995
  39. Shabalin V.N., Shatokhina S.N. Morphology of human biological fluids. Moscow: Chrysostom, 2001. P. 62. (In Russ.).
  40. Shatokhina S.N., Shabalin V.N. Morphology of biological fluids a new direction in clinical medicine. Almanac of Clinical Medicine. 2003; 6: 404—22 (In Russ.). eLIBRARY ID: 9464881
  41. Shatokhina S.N., Shabalin V.N. Autowave processes in blood serum. Almanac of Clinical Medicine. 1999; 2: 354—63 (In Russ.). eLIBRARY ID: 9463011
  42. Shatokhina S.N. Functional morphology of biological fluids a novel trend in clinical laboratory diagnosis. Almanac of Clinical Medicine. 2008; 18: 50—6 (In Russ.). eLIBRARY ID: 11667299
  43. Spinei A., Picos A.M., Romanciuc I., Berar A., Mihailescu A.M. The study of oral liquid microcrystallization in children with gastro-esophageal reflux disease. Clujul Med. 2014; 87 (4): 269—76. PMID: 26528035
  44. Shabalin V.N., Rasumova S.N., Uvarova D.S., Bulgakov V.S. The composition of chemical elements in oral fluid. Health and Education Millennium. 2015; 17 (2): 39—42 (In Russ.). eLIBRARY ID: 23239247
  45. Zaporozhchenko I.V., Toncheva E.D., Korol D.M. et al. Crystallography of biological fluids. Dental Science and Practice. 2015; 5 (10): 45—53. (In Russ.).
  46. Savina L.V., Pavlishchuk S.A., Samsygin V.Yu., Bolotova E.V., Gotovtseva L.P., Chekmareva S.E., Nuzhnaya I.A. Polarization microscopy in the diagnostics of metabolism disorders. Russian Clinical Laboratory Diagnostics. 2003; 3: 11—3 (In Russ.). eLIBRARY ID: 17038595
  47. Martusevich A.K. Crystallographic analysis: general characteristics. Medical Newsletter of Vyatka. 2002; 3: 59—64 (In Russ.). eLIBRARY ID: 19141540
  48. Martusevich A.K., Kamakin N.F., Zhdanova O.B., Simonova Zh.G., Kovaleva L.K., Shubina O.I., Krivonogova P.L. Evolution of concepts of crystallogenic properties of biological fluids and methodologies for their study. Medical Newsletter of Vyatka. 2013; 3: 30—5 (In Russ.). eLIBRARY ID: 21273660
  49. Martusevich A.K., Vorobyov A.V., Kamakin N.F., Zimin Yu.V. Chromocrystalloscopy as a method of modern biocrystallomics: essence, role and prospects. Vestnik of Lobachevsky University of Nizhni Novgorod. 2009; 1: 78—83 (In Russ.). eLIBRARY ID: 11741090
  50. Kamakin N.F., Martusevich A.K. Biotechnology of crystallogenesis of body fluids (experimental crystalloscopy). Medical Newsletter of Vyatka. 2005; 3-4: 44—51 (In Russ.). eLIBRARY ID: 19072965
  51. Martusevich A.K., Zimin Yu.V. To the question about experimental investigations of the biocrystallization. Journal of New Medical Technologies. 2008; 1 (XV): 14—6 (In Russ.). eLIBRARY ID: 13071910
  52. Kamakin N.F., Martusevich A.K., Koshkin A.N. Prospects for the development of crystallographic research methods. Medical Newsletter of Vyatka. 2003; 3: 6—11 (In Russ.). eLIBRARY ID: 19107827
  53. Vorob’ev A.V., Vorob’eva V.A., Vorob’eva I.G., Neshtakova N.L. Method for diagnosing blood cancer diseases. Patent RU No. 2250747, effective till 02.07.2021.

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Received

October 29, 2021

Accepted

November 28, 2021

Published on

December 1, 2021