DOI:

10.37988/1811-153X_2020_3_44

Efficiency of application of probiotics for correction of microbiocenosis and cytokine balance of the oral cavity of patients with chronic inflammatory diseases of periodontium

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Authors

  • V.V. Erichev 1, PhD in Medical Sciences, professor of the Dentistry Department at the Faculty of Advanced training and professional retraining
  • S.I. Risovannij 1, PhD in Medical Sciences, full professor of the Dentistry Department at the Faculty of Advanced training and professional retraining
  • E.S. Ovcharenko 1, PhD in Medical Sciences, associate professor of the Dentistry Department at the Faculty of Advanced training and professional retraining
  • S.V. Melekhov 2, PhD in Medical Sciences, professor, director of dental clinic
  • 1 Kuban State Medical University, 350063, Krasnodar, Russia
  • 2 “Metrostom” Dental Training Center, 350027, Krasnodar, Russia

Abstract

The aim of the study was to optimize a comprehensive treatment regimen for inflammatory periodontal diseases by including a probiotic and evaluating the microbiocenosis and cytokine profile in the mouth. Materials and methods. 120 patients were examined, of which 50 patients with chronic marginal gingivitis simple and 50 patients with chronic generalized periodontitis. Patients underwent a clinical, microbiological, mycological and immunological assessment of the state of the tissues of the periodontal complex before and after 3, 6 and 12 months after treatment. Of each group, 50% of patients received treatment according to the traditional method, and 50% according to an improved regimen using the Bifidumbacterin forte probiotic. Results. It has been established that in patients with chronic marginal gingivitis simple and chronic generalized periodontitis of moderate severity, a high degree of contamination of periodontal pockets with yeast-like fungi of the genus Candida and bacterial opportunistic microflora is determined, which is directly associated with an increase in pro-inflammatory cytokines (TNF-α, IL-8), a decrease in the concentration of INF-γ and an increase in the level of anti-inflammatory cytokine IL-4. Conclusions. A dynamic assessment of clinical and laboratory parameters against the background of complex therapy using a probiotic and a traditional method of treatment indicates an increase in the effectiveness of therapeutic measures for chronic marginal gingivitis simple by 40%, and chronic g periodontitis by 37%.

Key words:

gingivitis, periodontitis, biofilm, cytokines, probiotics

For Citation

[1]
Erichev V.V., Risovannij S.I., Ovcharenko E.S., Melekhov S.V. Efficiency of application of probiotics for correction of microbiocenosis and cytokine balance of the oral cavity of patients with chronic inflammatory diseases of periodontium. Clinical Dentistry (Russia).  2020; 3 (95): 44—47. DOI: 10.37988/1811-153X_2020_3_44

References

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Published on

September 15, 2020