DOI:

10.37988/1811-153X_2020_3_14

Effectiveness of the use of domestic nature immunostimulator in the treatment of herpes oral infection

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Authors

  • A.V. Shumsky 1, PhD in Medical Sciences, full professor of the Dentistry department, vice-rector of the Dental Academy
  • T.N. Modina 2, PhD in Medical Sciences, full professor of the Maxillofacial dentistry Department
  • 1 Medical University “REAVIZ”, 443099, Samara, Russian Federation
  • 2 Pirogov National Medical & Surgical Center, 105203, Moscow, Russia

Abstract

The article presents clinical and immunological results on the effectiveness of the domestic nature immunostimulator Stimforte in the treatment of chronic herpetic oral infection in a comparative aspect. The use of OPI in the algorithm of complex treatment affects the normalization of serum interferon content and increase the number of natural killers in patients, which significantly increases the remission of the disease. Material and methods. For the study, 32 women and 20 men with chronic herpes infection (HGI) between the ages of 18 and 50 were selected, without severe comorbidities, which were distributed to the main (n=29) and control (n=23) group. All patients received acyclovir 200 mg 4 times a day with a course of 10 days and Herpenox-gel — 3—5 times a day. Patients of the main group prescribed parenteral injection injections of Stimforte. The cytofluometric method was carried out to determine the content of whey interferon, NIC cells, CD56 cells and expression CD56 and CD3, CD56 and CD57, CD56 and CD16. Results. After therapy using Stimforte, the main group experienced a reliable increase in interferon levels to 34% and 14% in the control group. Monitoring patients after comprehensive treatment for four months showed that the main group increased the period of remission to 90 days, but in the control group remission observed about 32 days. Conclusion. The use of Stimforte in the complex treatment of HGI allows to quickly stop the inflammatory process, reduce the number of apths and optimize the regeneration of the mucosa of the mouth and skin, reducing the duration of relapses and significantly contributing to increase the period of remission of the disease.

Key words:

peptide immunostimulator, chronic herpetic infection, remission

For Citation

[1]
Shumsky A.V., Modina T.N. Effectiveness of the use of domestic nature immunostimulator in the treatment of herpes oral infection. Clinical Dentistry (Russia).  2020; 3 (95): 14—18. DOI: 10.37988/1811-153X_2020_3_14

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Published on

September 15, 2020