DOI:

10.37988/1811-153X_2018_3_39

Pathology of oral mucosa after intensive chemoradiotherapy (review)

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Authors

  • A.B. Chukhlovin 1, PhD in Medical Sciences, professor of the Hematology, transfusiology and transplantology Department, head of the molecular diagnostics Lab at the Pediatric oncology, hematology, and transplantology research Institute
  • A.P. Grigoriants 1, PhD in Medical Sciences, associate professor of the Dentistry diseases propaedeutics Department
  • 1 Pavlov University, 197022, Saint-Petersburg, Russia

Abstract

The review article deals with early and late oral and dental problems occurring after intensive anticancer chemo- and or radiotherapy and hematopoietic stem cell transplantation (HSCT). High-dose cytoreductive therapy may be accompanied by long-term cytopenias followed by slow recovery of myelo- and lymphopoiesis; complications of immunosuppressive treatment due to graft-versus-host disease (GVHD), i.e., post-transplant immune pathology is accompanied by high risk of dental infections thus requiring prophylactic caries treatment, and antiseptic regimens in cytopenic period. The therapy-associated affection of oral epithelial cells leads to early mucositis and aggravates acute graft-versus-host disease. Autoimmune-like complications (atrophy of oral epithelium and salivary glands, dry mouth syndrome) are frequently observed within several months after allogeneic HSCT. In pediatric patients, massive chemotherapy and radiation treatment is followed by stunted root growth, lagging primary dentition, hypoplasia of tooth enamel etc. Differential protocols are proposed for children and adults in order to perform prophylaxis and treatment of dental pathology in the patients undergoing auto- and allo-HSCT.

Key words:

hematopoietic stem cell transplantation, immunosuppressive treatment, oral epithelium, immune-mediated disorders, dental infections, treatment, prophylaxis

For Citation

[1]
Chukhlovin A.B., Grigoriants A.P. Pathology of oral mucosa after intensive chemoradiotherapy (review). Clinical Dentistry (Russia).  2018; 3 (87): 39—43. DOI: 10.37988/1811-153X_2018_3_39

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Published on

September 1, 2018